Anti-Carbamylated Protein Antibodies in Psoriatic Arthritis

Diagnostic Value of Antibodies Against Carbamylated Proteins in Psoriatic Arthritis.

Patrocinadores

Patrocinador principal: Association pour la Recherche Clinique et Immunologique

Fuente Association pour la Recherche Clinique et Immunologique
Resumen breve

Anti-carbamylated protein (anti-CarP) antibodies are present in approximately one-fourth of the patients who are seronegative for both rheumatoid factor and anti-citrullinated protein antibody and who may therefore have psoriatic arthritis. The investigators hypothesized that detection of anti-CarP antibodies in serum may be useful for diagnosis of psoriatic arthritis.

Estado general Completed
Fecha de inicio August 29, 2018
Fecha de Terminación April 24, 2019
Fecha de finalización primaria April 24, 2019
Fase N/A
Tipo de estudio Interventional
Resultado primario
Medida Periodo de tiempo
Sensitivity of anti-carbamylated protein antibodies for the diagnosis of psoriatic arthritis in the psoriatic population Anti-CarP antibodies will be assessed in the sera collected at the recruitment visit
Inscripción 300
Condición
Intervención

Tipo de intervención: Diagnostic Test

Nombre de intervención: Serum anti-CarP antibodies detection

Descripción: Serum anti-CarP antibodies detection using an enzyme-linked immunosorbent assay (ELISA) from Inova Diagnostics.

Elegibilidad

Criterios:

Inclusion Criteria:

- "Controls" : Patients with a psoriasis confirmed by a dermatologist and with absence of psoriatic arthritis confirmed by a rheumatologist.

- "Cases" : Patients with psoriatic arthritis fulfilling the classification criteria for psoriatic arthritis (CASPAR), with a diagnosis confirmed by a rheumatologist and associated with personal or familial psoriasis.

Exclusion Criteria:

- "Controls": Presence of any chronic rheumatic inflammatory disease such as psoriatic arthritis.

Género: All

Edad mínima: 18 Years

Edad máxima: 70 Years

Voluntarios Saludables: No

Ubicación
Instalaciones: Centre Hospitalier Lyon Sud
Ubicacion Paises

France

Fecha de verificación

November 2019

Fiesta responsable

Tipo: Sponsor

Tiene acceso ampliado No
Condición Examinar
Número de brazos 2
Grupo de brazo

Etiqueta: Controls

Tipo: Other

Descripción: Patients with psoriasis and without psoriatic arthritis.

Etiqueta: Cases

Tipo: Other

Descripción: Patients with psoriatic arthritis and with personal or familial psoriasis.

Acrónimo CARPAPA
Información de diseño del estudio

Asignación: Non-Randomized

Modelo de intervención: Parallel Assignment

Propósito primario: Diagnostic

Enmascaramiento: None (Open Label)

Fuente: ClinicalTrials.gov