- ICH GCP
- Registre américain des essais cliniques
- Essai clinique NCT00594477
Intensity Modulated Radiotherapy for Breast Cancer (IMRT)
8 août 2017 mis à jour par: Washington University School of Medicine
Intensity Modulated Radiation Therapy for Breast Cancer: A Phase I Feasibility Study
This study delivers radiation therapy to any residual breast tissue and the chest wall plus lymph node areas around the breast.
These lymph node areas are under the arm, around the collar bone, and under the sternum (breastbone).
Aperçu de l'étude
Description détaillée
IMRT treatment uses a computer-controlled x-ray (CT) to deliver radiation beams at several different angles and strengths to deliver precise doses to the regions at risk for recurrence of breast cancer while reducing or sparing the dose to critical structures (heart, lungs) and nearby normal tissue.
Type d'étude
Interventionnel
Inscription (Réel)
100
Phase
- La phase 1
Contacts et emplacements
Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.
Lieux d'étude
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Missouri
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Saint Louis, Missouri, États-Unis, 63110
- Washington University School of Medicine
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Critères de participation
Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.
Critère d'éligibilité
Âges éligibles pour étudier
18 ans et plus (Adulte, Adulte plus âgé)
Accepte les volontaires sains
Non
Sexes éligibles pour l'étude
Femelle
La description
Inclusion Criteria:
- Female gender
- Age ≥ 18 years
- Invasive primary female breast cancer
- Pathologically proven regional nodal metastasis
- Status post mastectomy or partial mastectomy with an assessment of axillary nodes via sentinel lymph node biopsy and/or axillary lymph node dissection.
- Signed study specific consent form
Exclusion Criteria:
- Distant metastasis
- Currently Pregnant
- Psychiatric or addictive disorders that preclude informed consent
- Time from initial diagnosis to the start of radiation therapy > one year
- Estimated life expectancy judged to be < one year
- Prior radiation to the ipsilateral breast or chest wall
- Primary breast cancer is lymphoma or sarcoma
- Patients being treated with concurrent chemotherapy.
Plan d'étude
Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: Traitement
- Répartition: N / A
- Modèle interventionnel: Affectation à un seul groupe
- Masquage: Aucun (étiquette ouverte)
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
---|---|
Expérimental: IMRT
The prescribed dose for all patients will be 5040 cGy in 28 fractions.
Patients will receive external beam treatment once a day, five days a week for approximately five and a half weeks.
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Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
---|---|---|
Evaluate the feasibility of adjuvant comprehensive radiation therapy via IMRT with daily set-up position verified using 3D verification
Délai: Within 1 year of protocol registration
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The study will be deemed infeasible if greater than 10% of enrolled patients have at least one of the following outcomes:
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Within 1 year of protocol registration
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Mesures de résultats secondaires
Mesure des résultats |
Description de la mesure |
Délai |
---|---|---|
Evaluate the rate and severity of both acute and late cutaneous toxicity
Délai: 6-8 months following completion of treatment and 12-14 months following completion of treatment
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6-8 months following completion of treatment and 12-14 months following completion of treatment
|
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Evaluate the rate and severity of late subcutaneous fibrosis
Délai: 6-8 months following completion of treatment and 12-14 months following completion of treatment
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6-8 months following completion of treatment and 12-14 months following completion of treatment
|
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Evaluate the rate of radiation pneumonitis
Délai: 6-8 weeks following completion of treatment, 3-4 months following completion of treatment, 6-8 months following completion of treatment, and 12-14 months following completion of treatment
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6-8 weeks following completion of treatment, 3-4 months following completion of treatment, 6-8 months following completion of treatment, and 12-14 months following completion of treatment
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Evaluate ipsilateral upper quadrant function
Délai: Pretreatment and 3-4 months following completion of treatment
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For patients who receive physical therapy, objective measures of the rotator cuff, bursa, and joint space will be evaluated by diagnostic ultrasound if medically indicated.
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Pretreatment and 3-4 months following completion of treatment
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Evaluate patient quality of life
Délai: Pretreatment, 6-8 months following completion of treatment, and 12-14 months following completion of treatment
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Pretreatment, 6-8 months following completion of treatment, and 12-14 months following completion of treatment
|
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Evaluate local-regional control rates
Délai: 12-14 months following completion of radiation therapy
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12-14 months following completion of radiation therapy
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Evaluate patient set-up reproducibility in breast cancer patients treated with IMRT using daily 3D position verification
Délai: 12-14 months following completion of treatment
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12-14 months following completion of treatment
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Collaborateurs et enquêteurs
C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.
Parrainer
Les enquêteurs
- Chercheur principal: Imran Zoberi, MD, Washington University School of Medicine
Publications et liens utiles
La personne responsable de la saisie des informations sur l'étude fournit volontairement ces publications. Il peut s'agir de tout ce qui concerne l'étude.
Publications générales
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- Huntzinger C, Munro P, Johnson S, Miettinen M, Zankowski C, Ahlstrom G, Glettig R, Filliberti R, Kaissl W, Kamber M, Amstutz M, Bouchet L, Klebanov D, Mostafavi H, Stark R. Dynamic targeting image-guided radiotherapy. Med Dosim. 2006 Summer;31(2):113-25. doi: 10.1016/j.meddos.2005.12.014.
Dates d'enregistrement des études
Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.
Dates principales de l'étude
Début de l'étude (Réel)
4 janvier 2008
Achèvement primaire (Réel)
8 août 2016
Achèvement de l'étude (Réel)
8 août 2016
Dates d'inscription aux études
Première soumission
4 janvier 2008
Première soumission répondant aux critères de contrôle qualité
14 janvier 2008
Première publication (Estimation)
15 janvier 2008
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
10 août 2017
Dernière mise à jour soumise répondant aux critères de contrôle qualité
8 août 2017
Dernière vérification
1 août 2017
Plus d'information
Termes liés à cette étude
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- 07-1077 / 201106403
Plan pour les données individuelles des participants (IPD)
Prévoyez-vous de partager les données individuelles des participants (DPI) ?
NON
Informations sur les médicaments et les dispositifs, documents d'étude
Étudie un produit pharmaceutique réglementé par la FDA américaine
Non
Étudie un produit d'appareil réglementé par la FDA américaine
Oui
produit fabriqué et exporté des États-Unis.
Non
Ces informations ont été extraites directement du site Web clinicaltrials.gov sans aucune modification. Si vous avez des demandes de modification, de suppression ou de mise à jour des détails de votre étude, veuillez contacter register@clinicaltrials.gov. Dès qu'un changement est mis en œuvre sur clinicaltrials.gov, il sera également mis à jour automatiquement sur notre site Web .
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Essais cliniques sur IMRT
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Royal Marsden NHS Foundation TrustComplété
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Washington University School of MedicineRésiliéCancer de la tête et du couÉtats-Unis