Nonprofit Nebraskan healthcare organization started the De-Escalation Protocol Of HPV Mediated Oropharyngeal Squamous Cell Carcinoma
Photo by Chris Liverani
Nebraska Methodist Health System is recruiting patients for the clinical trial of De-Escalation Protocol Of HPV Mediated Oropharyngeal Squamous Cell Carcinoma.
The purpose of this study is to evaluate the effects, good and/or bad, of treating participants with HPV-mediated oropharyngeal cancer, with less treatment, using the new staging system. The investigators believe this treatment will provide the same effectiveness as the usual treatment, but decrease the side effects. The radiation doses, chemotherapy doses, and the type of surgical approaches that will be used in this treatment protocol have all been previously investigated. Previous research suggests that this can be done safely, but there has not been a study done basing treatment on the new staging system.
The study will take place at the Nebraska Methodist Hospital, Omaha, Nebraska, United States.
Among primary outcome measures are Overall survival and Disease Free Survival.
The participants must not have any evidence of distant metastatic disease and tumors staged using AJCC TNM 8th edition Staging for Head and Neck cancers in order to be included into this study. There other inclusion criteria.
The participants must not be receiving or planning to receive any other clinical trial therapy or intervention. Participants with an unknown primary tumor who are both HPV positive and EBV positive are not eligible for this study.
The Nebraska Methodist Health System, also known as Bestcare, is a nonprofit Nebraskan healthcare organization that was founded in 1982. Its headquarters are located at 825 S. 169th Street in Omaha, Nebraska. The three major facilities in the system, Methodist Jennie Edmundson Hospital (Council Bluffs, Iowa), Methodist Women's Hospital (Elkhorn, Nebraska), and Methodist Hospital (Omaha, Nebraska), have served the Omaha-Council Bluffs metropolitan area for more than 120 years.
Created in 1982 by Methodist Hospital leaders, the system operates as a not-for-profit.
The page dedicated to this clinical trial can be found here: https://ichgcp.net/clinical-trials-registry/NCT04638465
