Epileptogenic Zone's Cartography by Quantification of EEG's Signal and Intracerebral Stimulation. (EPISTIM)
Epilepsy is a devastating chronic disease due to multiple causes that affect close to 50% of the world's population.
Although effective, epilepsy surgery fails in many cases, the percentage of patients free from crisis on a long term (≥ 5 years) varies from 27% to 66% according to the kind of epilepsy.
It is in this context that EPISTIM is interesting, and its aims isb a better electrophysiology delimiting of cortical networks that imply the genesis of seizures with the aim to improove surgery results.
This study will rely on the intracerebral records and on corticales electrical stimulation as they are currently routinely used by epileptic patients candidates for surgery.
調査の概要
研究の種類
入学 (予想される)
段階
- 適用できない
連絡先と場所
研究場所
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La Tronche、フランス、38700
- 募集
- UniversityHospitalGrenoble
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コンタクト:
- Philippe Kahane, Professor
- 電話番号:04.76.76.54.48
- メール:philippe.kahane@ujf-grenoble.fr
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コンタクト:
- Lorella Minotti
- 電話番号:0476765448
- メール:Lminotti@chu-grenoble.fr
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria :
- Patient from 5 to 65 years (L1121-7 L1122 2 CSP), including legally protected or unable to give his consent (L1121-8 CSP).
- Written approval of inclusion in the study from the patient or his legal representative.
- Patients with partial Epilepsy Drug Resistant , justifying a SEEG exploration.
Exclusion Criteria :
- Patient under 5 years.
- Patient over 65 years.
- Pregnant or breastfeeeding women (L1121-5 CSP).
- Patient deprived of liberty as a result of a judicial or administrative decision (L1121-6 CSP).
- Patients over 18 years unable to give their free consent and not subject to a legal protection order.
研究計画
研究はどのように設計されていますか?
デザインの詳細
- 割り当て:なし
- 介入モデル:単一グループの割り当て
- マスキング:なし(オープンラベル)
武器と介入
参加者グループ / アーム |
介入・治療 |
---|---|
他の:Partial Epilepsy Drug Resistant
Patients with partial Epilepsy Drug Resistant , justifying a SEEG exploration.
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Visual analysis : in order to define the level of cortical resections.
Epileptogenic maps : calculated for each crisis and for all crisis in general.
Connectivity maps : calculated for each site stimulated at low-frequency.
Post-operative evaluation : in order to assess the extent of resection.
他の名前:
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この研究は何を測定していますか?
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Visual analysis
時間枠:up to one hour
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Visual analysis : in order to define the level of cortical resections.
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up to one hour
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Epileptogenic maps
時間枠:up to 10 min
|
Epileptogenic maps : calculated for each crisis and for all crisis in general.
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up to 10 min
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Connectivity maps
時間枠:up to 10 min
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Connectivity maps : calculated for each site stimulated at low-frequency.
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up to 10 min
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MRI
時間枠:up to one hour
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Post-operative evaluation : in order to assess the extent of resection.
MRI : 3D-T1
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up to one hour
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協力者と研究者
捜査官
- 主任研究者:Philippe Kahane, Professor、Grenoble Hospital University
出版物と役立つリンク
一般刊行物
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研究記録日
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研究開始
一次修了 (予想される)
研究の完了 (予想される)
試験登録日
最初に提出
QC基準を満たした最初の提出物
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学習記録の更新
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最終確認日
詳しくは
本研究に関する用語
その他の研究ID番号
- 38RC14.079
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Functional stereotaxic explorationの臨床試験
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University of Southern CaliforniaNational Institutes of Health (NIH)積極的、募集していない
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Washington University School of MedicineMerck Sharp & Dohme LLC完了
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New York State Psychiatric InstituteUniversity of Miami; Columbia University; University of Southern California; Feinstein Institute...積極的、募集していない