- ICH GCP
- 미국 임상 시험 레지스트리
- 임상시험 NCT00038493
Temozolomide and SCH66336 for Recurrent Glioblastoma Multiforme
Phase II Evaluation Temozolomide and Farnesyl Transferase Inhibitor (SCH66336) for the Treatment of Recurrent and Progressive Glioblastoma Multiforme
연구 개요
상세 설명
Temozolomide at a dose of, 150-200 mg/m2, will be administered orally, after fasting for one hour, once a day for 5 consecutive days (days 1 through 5) every 4 weeks (plus up to 3 days). The starting dose level of 200 mg/m2 will be used for patients who have not previously received any chemotherapy or at 150 mg/m2 for patients who have received previous chemotherapy.
SCH66336 will be given orally, with water, in the morning and in the evening for three weeks (Days 8 - 28) every 28 days (plus up to 3 days) 1 hour before or after morning and evening meals. Patients will take 150 mg in the morning and 150 mg in the evening.
Treatment courses may be repeated every 28 days following the first daily dose of Temozolomide for the previous course.
연구 유형
등록 (실제)
단계
- 2 단계
연락처 및 위치
연구 장소
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Texas
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Houston, Texas, 미국, 77030
- UTMD Anderson Cancer Center
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참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
설명
Inclusion:
- Patients with histologically proven supratentorial glioblastoma multiforme (GBM).
- Patients must have shown unequivocal evidence for tumor recurrence or progression by MRI scan after radiation therapy. The scan done prior to study entry documenting progression will be reviewed by the primary investigator to document tumor volume changes to provide a gross assessment of growth rate.
- Patients may have had: a) no prior chemotherapy, b) 1 prior adjuvant chemotherapy, c) 1 prior adjuvant chemotherapy followed by 1 regimen for recurrent disease, or d) 1 or 2 prior chemotherapy regimens for recurrent or progressive tumor.
- All patients must sign an informed consent indicating that they are aware of the investigational nature of this study in keeping with the policies of this hospital.
- Patients must have shown unequivocal evidence for tumor progression by MRI or CT scan. A scan should be performed within 14 days prior to registration and on a steroid dose that has been stable for at least 5 days. If the steroid dose is increased between the date of imaging and registration a new baseline MR/CT is required. The same type of scan, i.e., MRI or CT must be used throughout the period of protocol treatment for tumor measurement.
Patients having undergone recent resection of recurrent or progressive tumor will be eligible as long as all of the following conditions apply:
- They have recovered from the effects of surgery.
- Residual disease following resection of recurrent tumor is not mandated for eligibility into the study. To best assess the extent of residual disease post-operatively, a CT/ MRI should be done no later than 96 hours in the immediate post-operative period or at least 4 weeks post-operatively, within 14 days prior to registration. If the 96-hour scan is more than 14 days before registration, the scan needs to be repeated. If the steroid dose is increased between the date of imaging and registration, a new baseline MRI/CT is required on a stable steroid dosage for at least 5 days.
- Patients must be > 18 years old, and with life expectancy > 8 weeks.
- Patients must have a Karnofsky performance status of > 60 (Karnofsky Performance Scale; Appendix C).
- Patients must have recovered from the toxic effects of prior therapy: 4 weeks from prior cytotoxic therapy and/or at least two weeks from vincristine, 6 weeks from nitrosoureas, 3 weeks from procarbazine administration, and 1 week for non-cytotoxic agents, e.g., interferon, tamoxifen, thalidomide, cis-retinoic acid, etc. (radiosensitizer does not count). Any questions related to the definition of non-cytotoxic agents should be directed to the Study Chair.
- Patients must have adequate bone marrow function (ANC> 1,500/mm3 and platelet count of > 100,000/mm3), adequate liver function (SGPT and alkaline phosphatase <2 times normal, bilirubin <1.5 mg%), and adequate renal function (BUN and creatinine <1.5 times institutional normal) prior to starting therapy.
- Patients must have a normal QT interval on an EKG done within 2 weeks prior to study entry.
- Patients must not be taking primidone, carbamazepine, phenobarbital or phenytoin anticonvulsants. Patients changing from these anticonvulsants to others that are allowed must be off the drugs listed above for at least 72 hours.
- Patients with a history of any other cancer (except non-melanoma skin cancer or carcinoma in-situ of the cervix), unless in complete remission and off of all therapy for that disease for a minimum of 3 years are ineligible.
Patients must not have:
- active infection
- disease that will obscure toxicity or dangerously alter drug metabolism
- serious intercurrent medical illness.
- prior recurrence with either Temozolomide or a farnesyl transferase inhibitor
- oral contraceptives and other hormonal methods (Depo-Provera) of birth control.
- Patients must not be pregnant and both male and female patients must practice adequate contraception.
Exclusion:
- Patients with a history of any other cancer (except non-melanoma skin cancer or carcinoma in-situ of the cervix), unless in complete remission and off of all therapy for that disease for a minimum of 3 years are ineligible.
Patients with the following are ineligible:
- active infection
- pregnancy and must practice adequate contraception
- disease that will obscure toxicity or dangerously alter drug metabolism
- serious intercurrent medical illness
- previous treatment with either Temozolomide or a farnesyl transferase inhibitor
- oral contraceptives and other hormonal methods (Depo-Provera) of birth control.
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 치료
- 할당: 무작위화되지 않음
- 중재 모델: 단일 그룹 할당
- 마스킹: 없음(오픈 라벨)
공동 작업자 및 조사자
연구 기록 날짜
연구 주요 날짜
연구 시작 (실제)
기본 완료 (실제)
연구 완료 (실제)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (추정)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 연구와 관련된 용어
추가 관련 MeSH 약관
기타 연구 ID 번호
- DM01-258
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
교모세포종 다형에 대한 임상 시험
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Celldex Therapeutics완전한교모세포종 | 교육종 | 소세포 교모세포종 | 거대 세포 교모세포종 | Oligodendroglial 성분을 가진 Glioblastoma미국, 캐나다, 호주, 이스라엘, 대만, 영국, 벨기에, 프랑스, 스페인, 독일, 오스트리아, 브라질, 콜롬비아, 체코, 그리스, 헝가리, 인도, 이탈리아, 멕시코, 네덜란드, 뉴질랜드, 페루, 스위스, 태국
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Celldex Therapeutics완전한교모세포종 | 교육종 | 재발성 교모세포종 | 소세포 교모세포종 | 거대 세포 교모세포종 | Oligodendroglial 성분을 가진 Glioblastoma | 재발된 교모세포종미국
Temozolomide and SCH66336에 대한 임상 시험
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University of OregonSpecial X Inc.모병부모-자녀 관계 | 육아 | 아동 행동 | 발달 장애 | 개발 지연 | 발달 장애, 아동미국
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University Hospitals Cleveland Medical Center알려지지 않은
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M.D. Anderson Cancer CenterSchering-Plough완전한
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M.D. Anderson Cancer Center완전한
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San Diego State UniversityRady Children's Hospital, San Diego알려지지 않은
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Istituto per la Ricerca e l'Innovazione BiomedicaFondazione di Comunità di Messina onlus모병
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GenSight Biologics모병
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University of North Carolina, Chapel HillNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Splendor-NC모병비만 | 초과 중량 | 체중 | 체중 감량 | 체중 변화 | 만성 질환 | 과체중 및 비만 | 신체 활동 부족 | 행동, 식사 | 중량 감소미국
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Monica E. KleinmanSchering-Plough완전한
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Dalarna UniversityUppsala University; The Swedish Research Council모병백치 | 가벼운 인지 장애 | 치매, 혼합 | 알츠하이머형 치매 | 주관적 인지 장애 | 치매 노인성스웨덴