Studie van hormoongerelateerde aandoeningen en fysiologie
De evaluatie en het beheer van hormoongerelateerde aandoeningen en fysiologie
Background:
Endocrine disorders involve changes to glands that produce hormones. Hormones are released by these glands into the blood so they can direct the function of other tissues in the body. Researchers want to study people who may have endocrine disorders. They want to learn more about the conditions that affect endocrine glands.
Objective:
To study adults with a variety of endocrine disorders for research and physician education.
Eligibility:
Adults ages 18 and older who have an endocrine or metabolic-related disorder
Healthy volunteers 18 and older
Design:
Participants will be screened with a review of their medical records.
Participants will have a physical exam and medical history.
The length of the study and the schedule will vary by participant. Tests may include:
Blood and urine tests
Stool and saliva samples
Imaging studies: Participants will lie on a table while a machine takes pictures of the body. They may be injected with a substance to make their organs more visible in the pictures.
Tests of endocrine tissue function
Consultation with other specialists
Sleep study
Medical photographs
Participants may be treated for their endocrine disorder. This could include:
Surgery. If tissue is removed during surgery, it may be studied.
Radiation
Medicine
Participants may have genetic testing. This will be done with a small amount of blood, cells from a cheek swab, or saliva.
Sponsoring Institution: National Institute of Digestive, Diabetes and Kidney Disease
Studie Overzicht
Toestand
Conditie
Interventie / Behandeling
Gedetailleerde beschrijving
Study Description:
This study allows the NIH Intramural Endocrinology Training Program (IETP) to follow or provide evaluation, treatment and or interventions to certain eligible subjects.
Objectives:
- To provide a repository of data and samples obtained during the course of clinical care to allow for future research.
- To add value to the IEFP training program by maintaining a diverse group of endocrine conditions seen at the NIH.
- To provide a vehicle by which pilot studies of endocrine physiology can be initiated.
- To identify prismatic cases that deviate from known presentations or responses to treatment.
- To evaluate the safety and results from adrenal venous sampling using a modified catheter with side hole placement.
Endpoints:
- Data from standard of care evaluation and management.
- Adverse events during and after adrenal vein sampling; cortisol and aldosterone results from the sampling.
Studietype
Inschrijving (Geschat)
Contacten en locaties
Studiecontact
- Naam: Raven N McGlotten, R.N.
- Telefoonnummer: (301) 827-0190
- E-mail: mcglottenr@mail.nih.gov
Studie Contact Back-up
- Naam: Lynnette K Nieman, M.D.
- Telefoonnummer: (301) 496-8935
- E-mail: niemanl@mail.nih.gov
Studie Locaties
-
-
Maryland
-
Bethesda, Maryland, Verenigde Staten, 20892
- Werving
- National Institutes of Health Clinical Center
-
Contact:
- For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)
- Telefoonnummer: TTY8664111010 800-411-1222
- E-mail: prpl@cc.nih.gov
-
-
Deelname Criteria
Geschiktheidscriteria
Leeftijden die in aanmerking komen voor studie
Accepteert gezonde vrijwilligers
Geslachten die in aanmerking komen voor studie
Bemonsteringsmethode
Studie Bevolking
any adult with a potential endocrine disorder; the types of disorders may vary to ensure that there is an adequate case mix of diagnoses for the training program.
Beschrijving
- INCLUSION CRITERIA:
In order to be eligible to participate in this study, an individual must meet all the following criteria:
- Adult men and women age 18 years or older.
- Known or suspected endocrine disorders requiring clinical screening, management and/or treatment and follow-up.
- Stated willingness to comply with all study procedures and availability for the duration of the study
EXCLUSION CRITERIA:
- Unstable participants and participants with severe organ failure, or those with a condition or medical treatment that may affect/limit the endocrine work-up and exhaust Clinical Center, IETP resources will be excluded if appropriate.
- Inability of a subject to adhere to a proposed schedule of visits.
- Inability to provide informed consent.
Studie plan
Hoe is de studie opgezet?
Ontwerpdetails
- Observatiemodellen: CASE_ONLY
- Tijdsperspectieven: PROSPECTIVE
Cohorten en interventies
Groep / Cohort |
Interventie / Behandeling |
|---|---|
|
Adults with Endocrine Disorder
Adults referred to NIH with possible endocrine conditions |
|
|
Adults with hyperaldosteronism
Adults referred to NIH or studied at NIH and determined to have hyperaldosteronism |
one or two side-holes will be created by the interventional radiologist to facilitate adrenal vein sampling |
Wat meet het onderzoek?
Primaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
|---|---|---|
|
Diagnosis/Treatment
Tijdsspanne: variable
|
determination of diagnosis and/or treatment of an endocrine disorder |
variable
|
Medewerkers en onderzoekers
Onderzoekers
- Hoofdonderzoeker: Lynnette K Nieman, M.D., National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Publicaties en nuttige links
Nuttige links
Studie record data
Bestudeer belangrijke data
Studie start (Werkelijk)
Primaire voltooiing (Geschat)
Studie voltooiing (Geschat)
Studieregistratiedata
Eerst ingediend
Eerst ingediend dat voldeed aan de QC-criteria
Eerst geplaatst (Werkelijk)
Updates van studierecords
Laatste update geplaatst (Werkelijk)
Laatste update ingediend die voldeed aan QC-criteria
Laatst geverifieerd
Meer informatie
Termen gerelateerd aan deze studie
Trefwoorden
Aanvullende relevante MeSH-voorwaarden
Andere studie-ID-nummers
- 190066
- 19-DK-0066
Plan Individuele Deelnemersgegevens (IPD)
Bent u van plan om gegevens van individuele deelnemers (IPD) te delen?
Beschrijving IPD-plan
WE currently have no plan to share this data, but in the future may consider sharing of this data for analysis with collaborators of with other expertise.
Informatie over medicijnen en apparaten, studiedocumenten
Bestudeert een door de Amerikaanse FDA gereguleerd geneesmiddel
Bestudeert een door de Amerikaanse FDA gereguleerd apparaatproduct
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