- ICH GCP
- US Clinical Trials Registry
- Klinisk utprøving NCT02799277
En multinomial prosessmodell for moralsk dømmekraft (PSY)
The main goal of this project to investigate the psychological processes underlying moral judgments in social dilemmas. We will examine neuroendocrine determinants of moral judgment by investigating the effects of exogenous testosterone
Studieoversikt
Status
Forhold
Intervensjon / Behandling
Detaljert beskrivelse
- Medical Screening Interview: Participants will be asked to answer several questions to identify potential medical and non-medical conditions that would preclude the self-administration of testosterone.
- First Saliva Sample: Participants will be asked provide a saliva sample after they completed the medical screening interview.
- Testosterone Self-Administration: Immediately following the first saliva collection, participants will self-administer spray puffs of either testosterone or placebo.
- Relaxation: Participants will be given the opportunity to relax for 30 minutes.
- Moral Dilemmas Judgments: Participants will be asked to read a set of 24 moral dilemmas that describe situations in which an actor has to make a decision on whether or not to engage in a particular action (e.g., sacrifice the well-being of one person to protect the well-being of several others). Participants will be asked to indicate whether they consider the described action acceptable or unacceptable.
- Demographics: Participants will be asked to indicate their gender, age, and ethnicity.
- Ear Temperature, heart rate, and blood pressure will be measured before drug administration, and again 20 minutes after drug administration. If temperature changes more than 2 degrees, heart rate changes more than 20bmp, or if blood pressure changes more than 20%, the experiment will be terminated and subjects will be escorted across the street to the University Emergency Room.
Studietype
Registrering (Faktiske)
Fase
- Fase 4
Kontakter og plasseringer
Studiesteder
-
-
Texas
-
Austin, Texas, Forente stater, 78712
- University of Texas at Austin Department of Psychology
-
-
Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
Tar imot friske frivillige
Kjønn som er kvalifisert for studier
Beskrivelse
Inclusion Criteria:
- must be currently enrolled at The University of Texas at Austin
Exclusion Criteria:
- not comfortable with the self-administration of testosterone for the purpose of our study less than 18 years old BMI less than 18 or above 27 suffer from any of the physical health conditions listed on the pre-screen questionnaire (I will not ask about mental health because our study is not about mental health) take any of the medications listed on the pre-screen questionnaire currently pregnant (females) irregular cycle in the past 6 months (females) smoke more than 5 cigarettes/day use cocaine more than once/month (**or should I exclude all those who use any drugs recreationally more than once/month?**) drink more than 10 alcoholic beverages/week
Studieplan
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Grunnvitenskap
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Trippel
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
|
Eksperimentell: Testosterone
14mg testosterone will be administered intranasally in a 1milliliter aqueous solution |
Effect of testosterone on moral decision making |
|
Placebo komparator: Placebo
1ml blank (containing no drug) aqueous solution will be administered intranasally |
Effect of testosterone on moral decision making |
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Probability of Making a Moral Judgment That Aligns With Moral Norms
Tidsramme: 90 minutes
|
Participants were asked to read and respond to a validated set of 24 moral dilemmas. The dilemma set included 4 parallel versions of 6 basic scenarios that varied in terms of whether (a) the dilemma involved a proscriptive norm that prohibits action or a prescriptive norm that prescribes action and (b) the benefits of the described action for overall well-being are either greater or smaller than its costs for overall well-being. Participants were asked to indicate for each dilemma whether or not they would perform the described action, using forced-choice options labeled yes and no. |
90 minutes
|
|
Probability of Making a Moral Judgment That Maximizes Welfare
Tidsramme: 90 minutes
|
Participants were asked to read and respond to a validated set of 24 moral dilemmas. The dilemma set included 4 parallel versions of 6 basic scenarios that varied in terms of whether (a) the dilemma involved a proscriptive norm that prohibits action or a prescriptive norm that prescribes action and (b) the benefits of the described action for overall well-being are either greater or smaller than its costs for overall well-being. Participants were asked to indicate for each dilemma whether or not they would perform the described action, using forced-choice options labeled yes and no. |
90 minutes
|
|
Probability of Making a Moral Judgment That Involves Inaction Versus Action
Tidsramme: 90 minutes
|
Participants were asked to read and respond to a validated set of 24 moral dilemmas. The dilemma set included 4 parallel versions of 6 basic scenarios that varied in terms of whether (a) the dilemma involved a proscriptive norm that prohibits action or a prescriptive norm that prescribes action and (b) the benefits of the described action for overall well-being are either greater or smaller than its costs for overall well-being. Participants were asked to indicate for each dilemma whether or not they would perform the described action, using forced-choice options labeled yes and no. |
90 minutes
|
Samarbeidspartnere og etterforskere
Sponsor
Etterforskere
- Hovedetterforsker: Robert A Josephs, PhD, Professor
Studierekorddatoer
Studer hoveddatoer
Studiestart (Faktiske)
Primær fullføring (Faktiske)
Studiet fullført (Faktiske)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Antatt)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- 2014-12-0010
Plan for individuelle deltakerdata (IPD)
Planlegger du å dele individuelle deltakerdata (IPD)?
Legemiddel- og utstyrsinformasjon, studiedokumenter
Studerer et amerikansk FDA-regulert medikamentprodukt
Studerer et amerikansk FDA-regulert enhetsprodukt
Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .