Forbedring av kognisjon etter kreft (I Can!)
En randomisert utprøving av fysisk aktivitet for kognitiv funksjon hos brystkreftoverlevere
This study will test whether a physical activity intervention can improve cognition in breast cancer survivors and help the development of physical activity guidelines for cognition in breast cancer survivors.
Studieoversikt
Status
Intervensjon / Behandling
Detaljert beskrivelse
Many breast cancer survivors experience problems with mental abilities such as memory, attention, and concentration (known as cognition). Increasing physical activity has been shown to improve cognition in adults; however, little is known about whether this is helpful for cancer survivors as well. This study will test whether a physical activity intervention can improve cognition in breast cancer survivors and help the development of physical activity guidelines for cognition in breast cancer survivors.
Studietype
Registrering (Faktiske)
Fase
- Ikke aktuelt
Kontakter og plasseringer
Studiesteder
-
-
California
-
La Jolla, California, Forente stater, 92093
- Moores UCSD Cancer Center
-
-
Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
Tar imot friske frivillige
Kjønn som er kvalifisert for studier
Beskrivelse
Inclusion Criteria:
- breast cancer survivors who have completed active treatment at least 6 months prior to enrollment and are within 5 years of diagnosis of stage 1, 2, or 3 breast cancer
- self-report difficulties with cognition since their cancer diagnosis
- self-report low levels of moderate to vigorous physical activity
- have a Fitbit compatible device with internet
- breast cancer was treated with chemotherapy and/or hormonal therapy
Exclusion Criteria:
- medical condition that could make it potentially unsafe to be in an unsupervised physical activity intervention
- currently taking tamoxifen or aromatase inhibitor that will be stopped in the next 6 months
- unable to commit to a 12-month study
Studieplan
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Behandling
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Enkelt
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
|
Eksperimentell: Exercise Intervention
This arm will receive a 12-month individually tailored phone and email-based exercise program. |
This intervention is based on Control Theory and Social Cognitive Theory and includes: 1) weekly emails with tips and tools to set personalized exercise goals and to increase exercise; 2) Health coaching phone sessions; 3) wrist worn monitor such as a Fitbit to track activity |
|
Aktiv komparator: Health & Wellness Intervention
This arm will receive a 12-month health and wellness program. |
This intervention includes: 1) weekly emails with tips and tools to support health and wellness such as brain health, stress management, nutrition; 2) Health coaching phone sessions |
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
National Institutes of Health Toolbox - Cognition Domain - Oral Symbol Digit Test
Tidsramme: Baseline to 6 months
|
The NIH Toolbox Oral Symbol Digit Test is a measure of processing speed, administered on an iPad by trained staff. Participants view a key pairing nine abstract symbols with the digits 1-9 and say aloud the digit that matches each symbol in a series, completing as many items as possible in 120 seconds. Higher scores indicate faster processing speed. |
Baseline to 6 months
|
Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
National Institutes of Health Toolbox - Cognition Domain - Oral Symbol Digital Test
Tidsramme: Baseline to 12 months
|
The NIH Toolbox Oral Symbol Digit Test is a measure of processing speed, administered on an iPad by trained staff. Participants view a key pairing nine abstract symbols with the digits 1-9 and say aloud the digit that matches each symbol in a series, completing as many items as possible in 120 seconds. Higher scores indicate faster processing speed. |
Baseline to 12 months
|
|
Patient Reported Outcomes Measurement Information System (PROMIS) Cognitive Abilities
Tidsramme: Baseline to 6 months and Baseline to 12 months
|
Patient-Reported Outcomes Measurement Information System (PROMIS) Item Bank v2.0 - Cognitive Function - Abilities Subset, administered as a computerized adaptive test (CAT), which assesses self-perceived cognitive abilities (e.g., memory, attention, and concentration) in daily life. Raw scores are converted to T-scores, standardized to a mean of 50 and standard deviation of 10 in the U.S. general population reference sample. Higher T-scores indicate better self-reported cognitive function. |
Baseline to 6 months and Baseline to 12 months
|
Samarbeidspartnere og etterforskere
Samarbeidspartnere
Publikasjoner og nyttige lenker
Generelle publikasjoner
- Hartman SJ, Shao LY, Zablocki RW, Natarajan L, Ahles T, Palmer BW, Sears DD, Tam RM, Mac V, Dillon L, Yan C, Parker BA. Effectiveness of an exercise intervention on cognition in breast cancer survivors: a randomized controlled trial. J Natl Cancer Inst. 2026 Sep 30:djag295. doi: 10.1093/jnci/djag295. Online ahead of print.
- Carlin D, Ott O, Sears DD, Ahles T, Desplats P, Hartman SJ. Exercise slows biological aging in breast cancer survivors: secondary analysis of a randomized trial. J Natl Cancer Inst. 2026 Sep 30:djag296. doi: 10.1093/jnci/djag296. Online ahead of print.
Studierekorddatoer
Studer hoveddatoer
Studiestart (Faktiske)
Primær fullføring (Faktiske)
Studiet fullført (Faktiske)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Faktiske)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- 182113
- 5R01CA225746 (U.S. NIH-stipend/kontrakt)
Plan for individuelle deltakerdata (IPD)
Planlegger du å dele individuelle deltakerdata (IPD)?
Legemiddel- og utstyrsinformasjon, studiedokumenter
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