IMRT Combined With Erlotinib for EGFR Wild Type Non-small Cell Lung Cancer With 4-10 Brain Metastases

Inclusion Criteria:

• Pathologically confirmed NSCLC and wild type EGFR
• 4-10 brain metastases on high quality CT scanning or MRI.
• No previous EGFR-TKI treatment.
• No previous brain radiotherapy.
• More than 4 weeks from last chemotherapy.
• Expected Survival of at least 2 months.
• KPS≥ 70
• RTOG RPA performance status 0-1
• Lab tests should meet these criteria: White blood cell count ≥3×10^9 /L;Platelet count≥100×10^9 /L;Total bilirubin 1.5 times or less the upper limits of normal (ULN); AST and ALT 1.5 times or less the ULN; Serum creatinine 1.5 times or less the ULN or creatinine clearance rate(CCR) greater than or equal to 60 ml/min.
• Pregnancy test (-)
• Be able to sign informed consent form.

Exclusion Criteria:

• With unstable systematical diseases (concluding acute infection, grade 4 hypertension, unstable angina pectoris, congestive heart failure, hepatopathy, nephropathy, metabolic diseases)
• With metastases on meninges.
• Taking antiepileptics (phenytoin sodium etc.) at the same time
• Unable to oral medication.
• Previous or recent another malignancy, except for nonmelanoma skin cancer or cervical cancer in situ