- ICH GCP
- Реестр клинических исследований США
- Клиническое испытание NCT00732836
Hepatic Arterial Infusion (HAI) of Abraxane
Phase I Trial of Hepatic Arterial Infusion of Abraxane With a Pharmacokinetic Study in Advanced Solid Cancer Patients With Predominant Hepatic Metastases
Обзор исследования
Статус
Вмешательство/лечение
Подробное описание
The Study Drug:
Nab-paclitaxel is designed to block cancer cells from dividing, which may cause the cells to die.
Giving nab-paclitaxel directly into the liver may allow a higher dose of the drug to be given, while avoiding some of the side effects that occur when high doses of chemotherapy are given other ways (for example, by vein into an arm).
Study Drug Dose Level:
If you are found to be eligible to take part in this study, you will be assigned to a study group based on when you joined this study. Up to 9 groups of 6 participants will be enrolled in Part 1 of the study, and up to 18 participants will be enrolled in Part 2. If you are enrolled in Part 1, the dose of the study drug you receive will depend on when you joined this study. The first group of participants will receive the lowest dose level of the study drug. Each new group will receive a higher dose of the study drug than the group before it, if no intolerable side effects were seen. This will continue until the highest tolerable dose of the study drug is found. If you are enrolled in Part 2, you will receive the study drug at the highest dose that was tolerated in the Part 1 portion.
Study Drug Administration:
The study drug will be given on Day 1 of "cycles" that are 21 days long. In Cycle 1 only, some participants may receive the study drug through a vein in their arm. The infusion will last 60 minutes. In Cycles 2 and later, you will receive the study drug through a catheter (a thin plastic tube). Each time the catheter is placed, you will be admitted to the hospital.
The doctor who performs the catheter placement procedure will explain it to you in more detail, and you will be asked to sign a separate consent form that describes the procedure and its risks in more detail.
You will be taken to the Interventional Radiology area, and the catheter will be placed in a blood vessel in your groin area, on the right side of your body. The catheter will be advanced to the liver. The catheter will be carefully taped in order to prevent it from moving or coming out while you are receiving the study drug. You will be on bedrest for the entire time that the catheter is in place.
After having the catheter inserted, you will be taken to the Nuclear Medicine area, and a test called "flow study" will be performed in order to confirm that the catheter is in the right place. The doctor who performs this test will explain it to you in more detail, and you will be asked to sign a separate consent form that describes the procedure and its risks in more detail.
After you return to your room, you will receive the study drug through the catheter over 60 minutes or 4 hours, depending on when you enroll. You will be asked to lie flat on your back while receiving the study drug.
The catheter will be removed by someone experienced in the procedure. It will be removed right after your study drug dose is complete. While the catheter is being removed, the study staff will apply pressure to your groin area for 15 minutes in order to stop the bleeding.
You will repeat this procedure once every 21 days. The catheter will be placed and removed each time.
Study Procedures and Tests:
Once a week, including before each dose of the study drug, blood (about 2 teaspoons) will be drawn for routine tests. These blood draws can be done at M. D. Anderson or somewhere else, if there is a place that is more convenient for you.
Once during each cycle (on a day when you are already in clinic), you will have a physical exam, including measurement of height, weight, and vital signs. Urine will be collected for routine tests.
At the end of every 3 cycles, you will have scans performed (the same type of scans as at screening) to check the status of the disease. If the study doctor feels it is appropriate, you may have blood drawn (about 1 teaspoon) to look for tumor markers.
Blood Testing for Research Purposes:
In Cycles 1 and 2, additional blood will be drawn for pharmacokinetic (PK) testing. PK testing measures the amount of study drug in the body at different time points. For participants receiving the study drug over 60 minutes, this blood (about 1 teaspoon each time) will be drawn on Day 1 (before you receive the study drug and at 5, 10, 20 and 40 minutes after the start of the dose, and then at 1, 1½, 2, 3, 4, and 6 hours after the start of the dose). Blood will also be drawn on Day 2 (24 hours after the start of the dose).
For participants receiving the study drug over 4 hours, this blood (about 1 teaspoon each time) will be drawn on Day 1 (before you receive the study drug and at 30 minutes after the start of the dose, and then at 1, 2, 3, 4, 4 ½, 5, 6, 7, and 9 hours after the start of the dose). Blood will also be drawn on Day 2 (24 hours after the start of the dose).
Length of Study Participation:
You will continue to receive the study drug once every 21 days. If the disease gets worse or intolerable side effects occur, you will be taken off the study drug.
End-of-Study Visit:
After your last dose of the study drug, you will have an end-of-study visit. At this visit, the following procedures will be performed:
- You will have a physical exam, including measurement of weight and vital signs.
- Blood (about 2 tablespoons) and urine will be collected for routine tests.
- To check the status of the disease, you will have scans performed (the same types of scans that you had before).
- If the study doctor feels it is appropriate, you may have blood drawn (about 1 teaspoon) to look for tumor markers.
This is an investigational study. Nab-paclitaxel is commercially available and FDA approved for use in breast cancer and for "systemic" use only. Systemic therapies affect the body as a whole. It is investigational to give nab-paclitaxel directly into the liver and to give it to patients with advanced cancer. At this time, giving it directly into the liver of patients with advanced cancer is only being done in research.
Up to 56 patients will take part in this study. All will be enrolled at M. D. Anderson.
Тип исследования
Регистрация (Действительный)
Фаза
- Фаза 1
Контакты и местонахождение
Места учебы
-
-
Texas
-
Houston, Texas, Соединенные Штаты, 77030
- University of Texas MD Anderson Cancer Center
-
-
Критерии участия
Критерии приемлемости
Возраст, подходящий для обучения
Принимает здоровых добровольцев
Полы, имеющие право на обучение
Описание
Inclusion Criteria:
- Pathologically confirmed diagnosis of advanced malignancy and liver involvement as predominant site of metastasis.
- An Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
- Adequate end-organ function as follows: Absolute neutrophil count (ANC) > or = 1500/mm3, Platelets > or = 100,000/mm3, Creatinine < or = 2.0 mg/dL or the calculated Glomerular filtration rate (GFR) > or = 40 mL/min if Creatinine > 2.0 mg/dL, ALT < or = 5 times upper limits of normal, Hb > 9.0 and Bilirubin < or = 2.0 mg/dL.
- Refractory to standard cancer therapy or who have no conventional therapy that produces a complete response rate of at least 10% or an increase in survival of at least 3 months.
- Ability to fully comprehend and willingness to sign the Institutional Review Board (IRB) approved informed consent
- Full recovery from any previous therapy and ability to receive cytotoxic agents.
- Patient is 18 years of age or older
Exclusion Criteria:
- Clinically significant ascites.
- Pregnant or breastfeeding females. Women of childbearing potential should be advised to avoid becoming pregnant and men to not father a child while receiving treatment. Women of childbearing potential must have a negative pregnancy test.
- Hypersensitivity to Abraxane
- Untreatable bleeding diathesis
- Evidence of portal vein thrombosis and clinically significant peripheral vascular disease
- Neuropathy of grade 2 or higher
- A known history of central nervous system (CNS) metastasis unless the patients are neurologically stable after treatment with surgery and/or radiation therapy
- If the patient progressed on abraxane previously they will not be eligible for the dose escalation portion or the PK studies only. These patients can be included in the dose expansion portion of the trial.
Учебный план
Как устроено исследование?
Детали дизайна
- Основная цель: Уход
- Распределение: Нерандомизированный
- Интервенционная модель: Одногрупповое задание
- Маскировка: Нет (открытая этикетка)
Оружие и интервенции
Группа участников / Армия |
Вмешательство/лечение |
---|---|
Экспериментальный: HAI Abraxane MTD
Dose escalation beginning Day 1, Cycle 2 dose level 180 mg/m^2 for maximum tolerated dose (MTD) of Hepatic Arterial Infusion of Abraxane (HAI Abraxane) following same dose intravenous Abraxane in Cycle 1 of 21 day cycle.
|
Escalating doses (beginning dose 180 mg/m^2) starting Day 1, Cycle 2 and later via hepatic arterial infusion (HAI) following IV Abraxane in Day 1, Cycle 1 for 21 day cycles.
Другие имена:
On each day of treatment for Cycles 2-4, hepatic artery catheter placement completed by interventional radiology.
Другие имена:
Intravenous (IV) Abraxane only in Cycle 1 (up to Dose Level 4 of 260 mg/m^2), infused over 60 minutes or 4 hours Day 1 of 21 day cycle.
Другие имена:
|
Экспериментальный: HAI Abraxane Expansion
HAI Abraxane dose expansion at MTD or dose level 3 (260 mg/m^2) if MTD not defined.
|
Escalating doses (beginning dose 180 mg/m^2) starting Day 1, Cycle 2 and later via hepatic arterial infusion (HAI) following IV Abraxane in Day 1, Cycle 1 for 21 day cycles.
Другие имена:
On each day of treatment for Cycles 2-4, hepatic artery catheter placement completed by interventional radiology.
Другие имена:
|
Что измеряет исследование?
Первичные показатели результатов
Мера результата |
Мера Описание |
Временное ограничение |
---|---|---|
Maximum Tolerated Dose (MTD) of HAI Abraxane
Временное ограничение: Assessments every 3 week cycle (21 days)
|
MTD is highest dose level in which 6 patients with at most 1 patient experiencing a dose limiting toxicity (DLT).
Dose escalation continues until DLT is defined or until dose level 4 is completed.
DLT defined during first cycle of treatment.
|
Assessments every 3 week cycle (21 days)
|
Соавторы и исследователи
Спонсор
Публикации и полезные ссылки
Полезные ссылки
Даты записи исследования
Изучение основных дат
Начало исследования
Первичное завершение (Действительный)
Завершение исследования (Действительный)
Даты регистрации исследования
Первый отправленный
Впервые представлено, что соответствует критериям контроля качества
Первый опубликованный (Оценивать)
Обновления учебных записей
Последнее опубликованное обновление (Оценивать)
Последнее отправленное обновление, отвечающее критериям контроля качества
Последняя проверка
Дополнительная информация
Термины, связанные с этим исследованием
Ключевые слова
Дополнительные соответствующие термины MeSH
- Заболевания пищеварительной системы
- Новообразования
- Новообразования по локализации
- Новообразования пищеварительной системы
- Заболевания печени
- Новообразования печени
- Молекулярные механизмы фармакологического действия
- Противоопухолевые агенты
- Модуляторы тубулина
- Антимитотические агенты
- Модуляторы митоза
- Противоопухолевые агенты растительного происхождения
- Паклитаксел
- Связанный с альбумином паклитаксел
Другие идентификационные номера исследования
- 2007-0857
- NCI-2012-02124 (Идентификатор реестра: NCI CTRP)
Эта информация была получена непосредственно с веб-сайта clinicaltrials.gov без каких-либо изменений. Если у вас есть запросы на изменение, удаление или обновление сведений об исследовании, обращайтесь по адресу register@clinicaltrials.gov. Как только изменение будет реализовано на clinicaltrials.gov, оно будет автоматически обновлено и на нашем веб-сайте. .
Клинические исследования Солидные опухоли
-
AstraZenecaРекрутингAdv Solid Malig - H&N SCC, ATM Pro / Def NSCLC, рак желудка, молочной железы и яичниковИспания, Соединенные Штаты, Бельгия, Соединенное Королевство, Франция, Венгрия, Канада, Корея, Республика, Австралия
Клинические исследования HAI Abraxane
-
Western Regional Medical CenterПрекращеноМетастатический рак молочной железыСоединенные Штаты
-
Association pour la Recherche sur le Temps Biologique...Pfizer; Merck Serono International SA; Gustave Roussy, Cancer Campus, Grand Paris; CR...НеизвестныйМетастатический колоректальный рак | Метастазы в печень | Поражения печениФранция, Италия, Бельгия, Португалия
-
Medical University of GdanskРекрутингМышечная дистрофия Дюшенна (МДД)Польша
-
Gustave Roussy, Cancer Campus, Grand ParisNational Cancer Institute, FranceПриостановленный
-
University Hospital, GhentCentre Hospitalier Universitaire Vaudois; University Ghent; Hopital Lariboisière; Kom... и другие соавторыЗавершенныйРак молочной железы Стадия IV | Перитонеальный карциноматоз | Рак яичников Стадия IIIC | Рак яичников IV стадия | Рак молочной железы Стадия IIIB | Рак молочной железы Стадия IIIc | Рак яичников Стадия IIIB | Рак желудка III стадии | Рак желудка IV стадии с метастазами | Рак поджелудочной железы, стадия... и другие заболеванияБельгия
-
Memorial Sloan Kettering Cancer CenterАктивный, не рекрутирующийРак прямой кишки | Рак толстой кишки | Печеночные метастазыСоединенные Штаты
-
Medical College of WisconsinОтозванКолоректальный рак | Метастаз | Рак печениСоединенные Штаты
-
Cancer Institute and Hospital, Chinese Academy...Еще не набираютГепатоцеллюлярная карциномаКитай
-
Spectrum Health HospitalsРекрутингАденокарцинома поджелудочной железы | Метастазы в печеньСоединенные Штаты
-
AIPING ZHOUЗавершенныйПродвинутый рак поджелудочной железыКитай