A Neurocognitive Model of Anorexia Nervosa

Inclusion:

• DSM-IV-TR™ diagnosis of anorexia nervosa (restricting or binge-purge subtype), current or prior;
• Age 16-45;
• Inpatient on GCRU
• Medically stable.

Exclusion:

• Any other current major Axis I disorder (including current bulimia nervosa), except major depression;
• History of concussion, seizure disorder, or other neurological illness;
• History of learning disability;
• Acute Suicidality

Healthy comparison group:

Inclusion:

• No current or past psychiatric illness;
• Age 16-45
• No history of binge eating or vomiting;
• Normal weight (80%-120% ideal body weight)

Exclusion:

• Significant medical or neurologic illness(concussion, seizure disorder, learning disability, other neurological illness)
• Current psychotropic medication or medications known to impact cognition

Additional Exclusion Criteria for fMRI:

• Significant Claustrophobia
• Pregnancy
• Indwelling metallic object, non-removable metal jewelry, medicinal patch or recent metallic ink tattoo
• For patients, current psychotropic medications (antidepressants for 2 week (prozac and antipsychotics for 4 weeks)
• For patients, any other current Axis I diagnosis