Efficacy and Feasibility of an Intermittent Weight Loss Program.
Efficacy and Feasibility of an Intermittent Weight Loss Program: A Pilot Study.
The goal of the study is to measure the effect of an approach including phases of active weight loss broken by weight stabilisation periods (named intermittent weight loss) on the metabolic profile.
First, the intermittent weight loss approach will contribute to create an artificial transitory steady state during the weight loss treatment that will help to minimize the adverse effects of the standard approach on muscle mass and resting metabolic rate. Second, despite a comparable fat mass loss, the intermittent weight loss approach will improve the metabolic profile to a greater degree compared to the standard approach. Finally, the intermittent weight loss approach will be associated with less weight regain after the treatment since the beneficial effect on muscle mass and metabolic rate.
研究概览
详细说明
研究类型
注册
阶段
- 不适用
联系人和位置
学习地点
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Quebec
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Sherbrooke、Quebec、加拿大、J1H 4C4
- Institut universitaire de gériatrie de Sherbrooke
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Women who had stopped menstruating for more than 1 year
- Waist circumference > 90 cm
- Sedentary (< 2 times a week of structured exercise)
- Non-smokers
- Low to moderate alcohol consumers (< 2 drinks per day).
Exclusion Criteria:
- We excluded subjects with the following conditions based on medical history and physical examination and on laboratory testing of kidney and liver functions, serum TSH, fasting glucose and lipid profile, and 75g-OGTT
- Cardiovascular disease, peripheral vascular disease or stroke
- Diabetes
- Moderate to severe hypertension (resting blood pressure > 170/100 mm Hg);
- Body weight fluctuation > 5 kg in the previous 6 months
- Thyroid or pituitary disease
- Hormonal replacement therapy at any time during the previous 6 months
- Medication that could affect the metabolic profile
学习计划
研究是如何设计的?
设计细节
- 主要用途:治疗
- 分配:随机化
- 介入模型:并行分配
- 屏蔽:无(打开标签)
研究衡量的是什么?
主要结果指标
结果测量 |
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Body composition (fat mass and lean body mass): after 0, 5, 10, 15, 20 and 25 weeks, as well as 12-month post-intervention
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次要结果测量
结果测量 |
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Fasting lipids: baseline, 5, 10, 15, 20 and 25 weeks, as well as 12-month post-intervention
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Resting metabolic rate: baseline, 5, 10, 15, 20 and 25 weeks, as well as 12-month post-intervention
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Resting blood pressure: baseline, 5, 10, 15, 20 and 25 weeks, as well as 12-month post-intervention
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OGTT: baseline and 25 weeks
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Dietary habits: baseline,25 weeks and 12-month post-intervention
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合作者和调查者
调查人员
- 首席研究员:Martin Brochu, PhD、Université de Sherbrooke
研究记录日期
研究主要日期
学习开始
研究完成
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.
热量控制饮食的临床试验
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Rush University Medical CenterUniversity of Chicago; National Institute on Aging (NIA); Advocate Hospital System招聘中
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University of CalgaryStewart Diabetes Education Fund完全的