Abdominal Fat and Imaging Measurements of Heart Disease
Visceral Obesity/Ectopic Fat and Non-invasive Markers of Atherosclerosis: A Cardiometabolic-cardiovascular Imaging Study
Although it is frequently mentioned in the media that overweight and obesity have reached epidemic proportions worldwide and in this country, some Canadians are perplexed and sometimes confused about the role of obesity in diabetes and heart disease. In fact, the investigators even hear from time to time that there could be "healthy" obese individuals. In clinical practice, assessment of obesity as a risk factor for cardiovascular disease (CVD) remains a challenge as even some physicians are confused. However, studies conducted in our laboratory and by other research teams around the world over the last 20 years have clearly shown that body shape is more important than body size when evaluating the risk of overweight/obesity and that high accumulation of abdominal fat (excess belly fat) increases the risk of diabetes and cardiovascular disease (CVD).
The investigators now need to better understand the link between excess belly fat and atherosclerosis (the thickening of artery walls by fatty deposits, also referred to as atherosclerotic plaque), leading to complications such as angina (chest pain) and myocardial infarction (heart attacks). Using non-invasive imaging techniques such as magnetic resonance imaging, the investigators therefore propose to examine the relationships between measures of fatness and of abdominal fat and the size of atherosclerotic plaque in large blood vessels of apparently healthy human subjects. This study is also a unique opportunity to look, for the first time, at the relationship between belly fat, blood sugar, several well-known risk factors for heart disease (cholesterol, blood pressure, cardiorespiratory fitness, etc.) and the size of atherosclerotic plaques. This research program should pave the way to the development of new improved preventive/therapeutic approaches focusing not on body weight but rather on abdominal fat and associated blood abnormalities which are predictive of the development of atherosclerotic plaques leading to the premature development of heart disease.
研究概览
研究类型
注册 (预期的)
联系人和位置
学习地点
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Quebec
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Québec、Quebec、加拿大、G1V 4G5
- 招聘中
- Institut Universitaire de Cardiologie et de Pneumologie de Québec
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首席研究员:
- DESPRÉS Jean-Pierre, PhD
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副研究员:
- DAGENAIS Gilles, MD
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副研究员:
- LAMARCHE Benoît, PhD
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副研究员:
- LAROSE Eric, DVM, MD
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副研究员:
- MATHIEU Patrick, MD
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副研究员:
- PIBAROT Philippe, DVM, PhD
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副研究员:
- POIRIER Paul, MD, PhD
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副研究员:
- RHÉAUME Caroline, MD, PhD
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Men and women aged 35-65 years
Exclusion Criteria:
- Massive obesity (BMI ≥ 40 kg/m2)
- Pharmacological treatment for lipids, hypertension and/or type 2 diabetes
- Clinical signs of cardiovascular disease
- Chronic inflammatory or auto-immune diseases
- Pulmonary diseases on corticosteroids
- Cancers not in remission
- History or clinical evidence of coronary heart disease (CHD)
- History of revascularisation procedures
- Current smoking
- Hormonal replacement therapy
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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Observational, longitudinal study
Adult men and women representative of the population of asymptomatic adult men and women aged from 35-65 years living in the Québec City metropolitan area
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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Change in carotid vessel wall volume measured by magnetic resonance imaging (MRI)
大体时间:Change between baseline and 3-year follow-up
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Cross-sectional and longitudinal analyses of the relationships between indices of body fat distribution, visceral adiposity/ectopic fat deposition, cardiorespiratory fitness and non-invasive measurements of macrovascular atherosclerosis
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Change between baseline and 3-year follow-up
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
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Change in abdominal adipose tissue measured by computed tomography (CT)
大体时间:Change between baseline and 3-year follow-up
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Visceral and subcutaneous adipose tissue will be determined at both L2-L3 and L4-L5 levels
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Change between baseline and 3-year follow-up
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Change in epi- and pericardial fat measured by magnetic resonance imaging (MRI)
大体时间:Change between baseline and 3-year follow-up
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Change between baseline and 3-year follow-up
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合作者和调查者
调查人员
- 首席研究员:DESPRÉS Jean-Pierre, PhD、Université Laval/Institut universitaire de cardiologie et de pneumologie de Québec
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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