Glaucoma Within Northern Ireland Cohort for the Longitudinal Study of Ageing (GwNICOLA)
Glaucoma is the leading cause of irreversible blindness worldwide. It is caused by damage to the optic nerve between the back of the eye and the brain leading to progressive blindness. The cause is poorly understood but ageing, increased intraocular pressure (IOP) and genetics are all likely to play a role. There is no cure for glaucoma but treatments are available which slow progression. Because vision cannot be restored once lost, early detection, monitoring and early treatment are all essential to preserve visual function.
The condition is diagnosed using a combination of the appearance of the optic nerve on clinical examination or photograph and visual field testing (perimetry). Measurement of IOP and measurement of the thickness of the retinal layers at the back of the eye complement diagnostic decisions.
The Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA) study does not include perimetry in the series of tests carried out on all participants but does include photography of the optic nerve, measurement of IOP and measurement of retinal thickness. Therefore we propose to invite back participants of the NICOLA study who have abnormal optic discs and high eye pressure to return for perimetry to confirm a diagnosis of glaucoma. Calling back participants for perimetry is essential to make the diagnosis not only for estimating prevalence but also for identifying participant's ill-health.
The primary aim of this study is to quantify the number of participants in the NICOLA study who have glaucoma and report its risk factors. This will allow an estimate of the number of people in the whole of NI with glaucoma. We will also perform a series of novel tests using state-of-the-art technologies to assess if they are better than current tests at diagnosing glaucoma. This may enable better informed decisions about policy decisions in eyecare.
研究概览
详细说明
Purpose and design: This study will answer the following research questions:
- What is the prevalence of glaucoma within the NICOLA cohort and which systemic and socioeconomic factors influence its prevalence?
- What is the diagnostic accuracy (sensitivity and specificity) of Retinal Nerve Fibre Layer (RNFL) thickness measurements in the diagnosis of glaucoma?
- What is the diagnostic accuracy (sensitivity and specificity) of macular thickness analysis in the diagnosis of glaucoma?
- What is the agreement between intraocular pressure measurement by Ocular Response Analyser (ORA) and Goldmann tonometry?
- What is the correlation between structural (circumpapillary RNFL or macular Ganglion Cell Complex thickness) or functional measurements (retinal oximetry or perimetry) and Optical Coherence Tomography angiography parameters (% vessel density and vessel calibre) in the assessment of glaucoma?
研究类型
注册 (实际的)
联系人和位置
学习地点
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Northern Ireland
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Belfast、Northern Ireland、英国、BT12 6BA
- Northern Ireland Clinical Research Facility
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参与标准
资格标准
适合学习的年龄
- 孩子
- 成人
- 年长者
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Participants of the NICOLA study who gave permission to be contacted by the NICOLA study team in future and
- Vertical cup to disc ratio ≥0.7 and/or inter-eye asymmetry ≥0.2 or neuroretinal rim ≤0.1 or intraocular pressure ≥25 mmHg.
Exclusion Criteria:
- Non English speakers or
- Participants of the NICOLA study who did not give permission to be contacted by the NICOLA study team in future
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
干预/治疗 |
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Glaucoma within NICOLA
NICOLA study Participants Eligible for GwNICOLA by meeting inclusion criteria
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SD-OCT Angiography
SD-OCT
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Prevalence of Glaucoma in Northern Ireland
大体时间:1 day [2 hours]
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Prevalence of Glaucoma in Northern Ireland
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1 day [2 hours]
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Diagnostic Accuracy of Spectral Domain OCT
大体时间:1 day [2 hours]
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Diagnostic Accuracy of Spectral Domain OCT
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1 day [2 hours]
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合作者和调查者
调查人员
- 首席研究员:Augusto Azuara-Blanco, PhD, MD、Queens University Belfast
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.
SD-OCT Angiography的临床试验
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Optovue完全的
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Duke UniversityOptovue终止
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Universidade do PortoCentro Hospitalar Universitário de Santo António; Faculty of Medicine (FMUP)招聘中
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University of Zurich完全的
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University Hospital Inselspital, Berne招聘中青光眼 | 黄斑变性 | 葡萄膜炎 | 糖尿病性视网膜病变 | 糖尿病性黄斑水肿 | 黄斑水肿 | 视网膜静脉阻塞 | 视神经疾病 | 视网膜脱离 | 黄斑部疾病 | 视网膜疾病 | 视网膜新生血管 | 视网膜动脉阻塞 | 高血压性视网膜病变 | 视网膜水肿 | 视网膜营养不良瑞士