Agency in Dystonia (AGENT10)
Neuronal Correlates of Agency in Dystonia
In this study, using computerized cognitive assessments combined with multi-modal neuroimaging approach investigators aim to address three specific questions on patients with cervical and myoclonus dystonia:
(i) investigate various aspects of the sense of agency and relationship to the severity of dystonia symptoms, (ii) characterize the possible link between abnormalities of movement perception and alteration of sense of agency in dystonia, (iii) (identify the neuronal underpinnings of the defective sense of agency in dystonia.
研究概览
详细说明
This is a single-centre, two-group ( dystonia and control), case-control study using behavioural and novel multimodal neuroimaging techniques to address the study aims.
The battery of the tasks will include explicit-agency tasks, a visual discrimination task on objects movement perception. The magnetic resonance acquisition protocol will include MP2RAGE structural (10 min duration), multi echo (3 echo times) multiband (MB factor 4) resting state functional neuroimaging (15 minutes duration) and multi shell diffusion imaging sequence (15 minutes duration)
研究类型
注册 (预期的)
阶段
- 不适用
联系人和位置
学习地点
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Ile De France
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Paris、Ile De France、法国、75013
- Centre d'Investigation Clinique
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- diagnosis of isolated adult-onset cervical dystonia (CD) or myoclonus dystonia (MD);
- duration of disease of more than one year
- no botulinum toxin injection for at least three months before the study
- normal or corrected-to-normal vision.
Exclusion Criteria
- any neurological history except for dystonia,
- history of dopamine antagonist treatment,
- secondary dystonia,
- dystonia in the upper limbs,
- inability to maintain gaze straight.
学习计划
研究是如何设计的？
设计细节
- 主要用途：基础科学
- 分配：非随机化
- 介入模型：并行分配
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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其他：Patients
25 patients with cervical and 25 patients with myoclonus dystonia
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Cognitive behavioral testing and cerebral MRI
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其他：Controls
50 healthy volunteers matched to patents ( age, sex)
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Cognitive behavioral testing and cerebral MRI
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
agency tasks behavioral outcome measures
大体时间：throughout study completion, an average 2 years
|
response time
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throughout study completion, an average 2 years
|
|
agency tasks behavioral outcome measures
大体时间：throughout study completion, an average 2 years
|
response accuracy in tasks trials
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throughout study completion, an average 2 years
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
MRI measures
大体时间：throughout study completion, an average 2 years
|
cortical thickness
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throughout study completion, an average 2 years
|
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MRI measures
大体时间：throughout study completion, an average 2 years
|
basal ganglia volume
|
throughout study completion, an average 2 years
|
合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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