Gas Exchange Kinetics and Work Load During Exercise
2021年2月9日 更新者:University of California, Irvine
Gas Exchange Kinetics and Work Load During Different Exercise Protocols in Healthy Children and Young Adults
The purpose of this research study is to understand how different kinds of exercise affect the human body and the health of the heart and lungs.
For example, some people like to exercise continuously for relatively long periods of time while others like to exercise for short periods of time with rest periods in between.
Children tend to exercise in frequent bouts of brief exercise interspersed with periods of rest.
Also, some people like running or treadmill exercise while others like to work out on stationary bicycles.
To date, standard exercise testing is based on a century-old paradigm used predominantly for adults that involves maximal exercise protocols (cardiopulmonary exercise testing-CPET).
Moreover, different but widely used exercise modalities such as cycle ergometer and treadmills are currently impossible to compare in children, and this has limited the clinical and research application of such testing in the pediatric age-range.
A major premise of this laboratory is that laboratory testing of cardiopulmonary fitness in children should be based on protocols that mimic naturally occurring patterns of exercise in children, rather than those that have been artificially employed to assess maximal efforts in adults.
This research project designed to begin the process of systematically identifying protocols can be best used for children and young adults.
Participants will exercise in different protocols on a bicycle ergometer or treadmill.
This research could lead to improved and more accurate fitness assessment and pave the way to an improved personalized exercise program in health and illness.
研究概览
研究类型
介入性
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。
学习地点
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California
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Irvine、California、美国、92697/92617
- Pediatric Exercise and Genomics Research Center, University of California, Irvine
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参与标准
研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
7年 至 35年 (孩子、成人)
接受健康志愿者
是的
有资格学习的性别
全部
描述
Inclusion Criteria:
- Between the ages of 7-35 years old without any known respiratory, cardiac or metabolic disease
- Determined to be in good health by preparticipation history
- No evidence of disease or disability that would impair participation in an exercise testing
- No chronic prescribed medication
Exclusion Criteria:
- Other limitation which in the eyes of the physician that would preclude ability to perform exercise testing
- Use of illegal drugs or abuse of alcohol
- Pregnancy or breastfeeding
学习计划
本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。
研究是如何设计的?
设计细节
- 主要用途:基础科学
- 分配:随机化
- 介入模型:交叉作业
- 屏蔽:单身的
武器和干预
参与者组/臂 |
干预/治疗 |
---|---|
实验性的:Treadmill Exercise in Adolescents and Adults
Comparison of gas exchange kinetics between treadmill and cyclo ergometer exercises
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Comparison of stationary bike and treadmill exercise among adolescents and adults
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实验性的:Cyclo Ergometer Exercise in Adolescents and Adults
Comparison of gas exchange kinetics between treadmill and cyclo ergometer exercises
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Comparison of stationary bike and treadmill exercise among adolescents and adults
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Maximum Oxygen Uptake (VO2) measurements during exercise
大体时间:4 weeks
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Breath by breath gas exchange VO2 in response to exercise.
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4 weeks
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Carbon Dioxide Production (VCO2) measurements during exercise
大体时间:4 weeks
|
Breath by breath gas exchange VCO2 in response to exercise
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4 weeks
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Minute Ventilation (VE) measurements during exercise
大体时间:4 weeks
|
Breath by breath gas exchange Minute ventilation (VE) in response to exercise
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4 weeks
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Heart Rate (HR) measurements during exercise
大体时间:4 weeks
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Breath by breath gas exchange HR values in response to exercise
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4 weeks
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Physical fitness evaluation
大体时间:4 weeks
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Physical activity questionnaire - Points are given to each level of activity, the mean of these points are taken which will give a physical activity summary score
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4 weeks
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Leisure time evaluation
大体时间:4 weeks
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Godin Leisure Time Exercise questionnaire - Total score will be measured Godin Leisure Time Exercise questionnaire - Total leisure activity score is calculated from points given to each level of activity from light to strenuous
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4 weeks
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Lean body mass measurements by Dial X-Ray Absorbiometry (DXA)
大体时间:4 weeks
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lean body mass in kg's
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4 weeks
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Fat percentage measurements by Dial X-Ray Absorbiometry (DXA)
大体时间:4 weeks
|
percent of fat tissue
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4 weeks
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Fat free mass measurements by Dial X-Ray Absorbiometry (DXA)
大体时间:4 weeks
|
fat free mass in kg's
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4 weeks
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Bone mass measurements by Dial X-Ray Absorbiometry (DXA)
大体时间:4 weeks
|
bone mass in kg's
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4 weeks
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Muscle mass measurements
大体时间:4 weeks
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Muscle mass in kg's will be determined by ultrasound
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4 weeks
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Puberty status measurements by using a growth and development questionnaire
大体时间:4 weeks
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Children will fill a standard Tanner Staging questionnaire.
The Tanner staging defines the physical characteristics of individuals.
A Tanner stage status assigned to each child depending on their primary and secondary sexual development characteristics.
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4 weeks
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Measurement of tissue oxygenation
大体时间:4 weeks
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Concentration of oxy- and de-oxyhemoglobin will be measured non-invasively
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4 weeks
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Measurements of breath rate
大体时间:4 weeks
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Respiratory sensors will be used to evaluate breath rate
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4 weeks
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Measurements of lung volume
大体时间:4 weeks
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Spirometry will be used to evaluate lung volume
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4 weeks
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2016年4月25日
初级完成 (实际的)
2016年4月25日
研究完成 (实际的)
2016年4月25日
研究注册日期
首次提交
2018年11月8日
首先提交符合 QC 标准的
2018年12月6日
首次发布 (实际的)
2018年12月10日
研究记录更新
最后更新发布 (实际的)
2021年2月12日
上次提交的符合 QC 标准的更新
2021年2月9日
最后验证
2021年2月1日
更多信息
与本研究相关的术语
其他研究编号
- 2015-2467
药物和器械信息、研究文件
研究美国 FDA 监管的药品
不
研究美国 FDA 监管的设备产品
不
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.
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