Effect of Sciatic Nerve Mobilization on Lower Extremity Pain Perception

April 24, 2026 updated by: Sümeyye Akçay, Fenerbahce University

The Effect of Sciatic Nerve Mobilization on Pain Perception in Lower Extremity Peripheral Nerves

This randomized controlled study aims to investigate the effect of sciatic nerve mobilization on pain perception in lower extremity peripheral nerves, specifically the tibial and common peroneal nerves. The study will be conducted in university students at Fenerbahçe University. Participants will be randomly assigned to either an intervention group or a control group.

Pressure pain threshold (PPT) will be measured using a pressure algometer at standardized anatomical points over the tibial and common peroneal nerves before and after the intervention period. Demographic and clinical information, including age, sex, height, weight, dominant lower extremity, physical activity level, history of lower extremity injury or surgery, neurological or systemic disease, and regular medication use, will also be recorded.

Participants in the intervention group will receive a standardized sciatic nerve mobilization protocol consisting of sliding-type neurodynamic mobilization performed in the supine position, including components of hip flexion, knee extension, and ankle dorsiflexion/plantarflexion in a rhythmic sequence. No intervention will be applied to the control group. The primary purpose of the study is to determine whether sciatic nerve mobilization changes pressure pain threshold values in the tibial and common peroneal nerves compared with no intervention.

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Enrolling by invitation

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.

Detailed Description

This randomized controlled pilot study aims to investigate the effect of sciatic nerve mobilization on pain perception in lower extremity peripheral nerves, specifically the tibial nerve and the common peroneal nerve, in healthy university students. The study will be conducted at Fenerbahçe University.

A total of 34 participants will be included. Eligible participants will be students aged 18 to 30 years at Fenerbahçe University who voluntarily agree to participate and meet the study eligibility criteria. Participants will be randomly assigned to an intervention group or a control group.

Pain perception will be assessed using pressure pain threshold measurements obtained with a pressure algometer at standardized anatomical points over the tibial and common peroneal nerves. Measurements will be performed before and after the study procedure using the same protocol for all participants.

Participants in the intervention group will receive a standardized sliding-type sciatic nerve mobilization protocol performed in the supine position. The mobilization includes coordinated movements of hip flexion, knee extension, and ankle dorsiflexion/plantarflexion to create a sliding effect on the sciatic nerve. The control group will not receive any intervention.

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Interventional

Enrollment (Estimated)

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
34

Phase

Phase

The stage of a clinical trial studying a drug or biological product, based on definitions developed by the U.S. Food and Drug Administration (FDA). The phase is based on the study's objective, the number of participants, and other characteristics. There are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4. Not Applicable is used to describe trials without FDA-defined phases, including trials of devices or behavioral interventions.
  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact

The name and contact information for the person who can answer enrollment questions for a clinical study. Each location where the study is being conducted may also have a specific contact, who may be better able to answer those questions.

Study Locations

  • Turkey (Türkiye)
    • Ataşehir
      • Istanbul, Ataşehir, Turkey (Türkiye), 34758
        • Fenerbahçe University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Aged 18 to 30 years
  • Being a student at Fenerbahçe University
  • No history of major trauma or surgery in the lower extremity within the last 6 months
  • Voluntarily agreeing to participate in the study and signing the informed consent form

Exclusion Criteria:

  • History of neurological disease
  • History of lower extremity peripheral nerve injury
  • Having undergone lower extremity surgery within the last 6 months
  • Regular use of analgesic or muscle relaxant medications
  • Pregnancy
  • Presence of any systemic disease that may interfere with the assessment or intervention procedures

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm

Participant Group / Arm

A group or subgroup of participants in a clinical trial that receives a specific intervention/treatment, or no intervention, according to the trial's protocol.
Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.
Experimental: Sciatic Nerve Mobilization Group
Participants in this group will receive a standardized sliding-type sciatic nerve mobilization. Pressure pain threshold of the tibial and common peroneal nerves will be measured before and after the intervention.
Other: Sciatic Nerve Mobilization
A standardized sliding-type sciatic nerve mobilization will be applied in the supine position. The technique includes coordinated hip flexion, knee extension, and ankle dorsiflexion/plantarflexion movements to produce a sliding effect on the sciatic nerve.
No Intervention: Control Group
Participants in this group will receive no intervention. Pressure pain threshold of the tibial and common peroneal nerves will be measured before and after the study procedure.

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
Measure Description
Time Frame
Pressure Pain Threshold of the Tibial Nerve
Time Frame: Before intervention and immediately after intervention
Pressure pain threshold of the tibial nerve will be assessed using a pressure algometer at a standardized anatomical point in the popliteal fossa. The algometer probe will be placed perpendicular to the skin, and pressure will be gradually increased until the participant first reports pain. The recorded value will be used as the pressure pain threshold.
Before intervention and immediately after intervention
Pressure Pain Threshold of the Common Peroneal Nerve
Time Frame: Before intervention and immediately after intervention
Pressure pain threshold of the common peroneal nerve will be assessed using a pressure algometer at a standardized anatomical point around the fibular head/neck region. The algometer probe will be placed perpendicular to the skin, and pressure will be gradually increased until the participant first reports pain. The recorded value will be used as the pressure pain threshold.
Before intervention and immediately after intervention

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
Fenerbahce University

Investigators

Investigators

A researcher involved in a clinical study. Related terms include site principal investigator, site sub-investigator, study chair, study director, and study principal investigator.
  • Principal Investigator: Sümeyye Akçay, Asst. Prof., Fenerbahçe University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
March 20, 2026

Primary Completion (Estimated)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
May 1, 2026

Study Completion (Estimated)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
May 1, 2026

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
April 6, 2026

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
April 6, 2026

First Posted (Actual)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
April 13, 2026

Study Record Updates

Last Update Posted (Actual)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
April 27, 2026

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
April 24, 2026

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
April 1, 2026

More Information

Terms related to this study

Keywords

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • FenerbahceUniver

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

Individual participant data (IPD) will not be shared because the study involves a small sample from a single university population, and data sharing could increase the risk of participant identification.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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