- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00005556
Retention of Bone Marrow Donors in a National Registry
Study Overview
Status
Conditions
Detailed Description
BACKGROUND:
As bone marrow transplantation becomes one of the preferred treatments for life-threatening diseases of the blood, increasing numbers of patients must seek compatible marrow from unrelated donors. The low probability of finding a good patient-donor marrow match means that between one- to two-thirds of ill patients never locate a donor with perfectly compatible marrow. Furthermore, once volunteers are identified as a preliminary match for a patient, 30 to 40 percent are either unwilling or medically unable to actually donate marrow. Thus, volunteer attrition contributes significantly to the problems already inherent in finding a suitable donor candidate.
DESIGN NARRATIVE:
The study examined the relationship of volunteer characteristics and donor center factors to volunteer psychological outcomes during two critical stages in the blood testing process and to donor center rates of volunteer cooperation at these stages.
Longitudinal and cross-sectional survey data were gathered from a total of over 2,900 potential marrow donors who were at one of two critical decision points in the process leading to donation (DR-blood-typing, CT-blood-typing), and from personnel at the 100 NMDP donor centers. These data allowed the investigators to (a) describe the distribution and interrelationships between donor center structural characteristics and the strategies centers utilize for volunteer recruitment and retention, (b) determine which donor center factors (both structural and tactical) and volunteer background characteristics best predict positive volunteer-specific psychological outcomes at later typing stages, and examine and revise models of individual volunteer-specific outcomes and aggregate across-center retention rates.
The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
Study Type
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Study Plan
How is the study designed?
Collaborators and Investigators
Investigators
- Galen Switzer, University of Pittsburgh
Publications and helpful links
General Publications
- Dew MA, Switzer GE, DiMartini AF, Matukaitis J, Fitzgerald MG, Kormos RL. Psychosocial assessments and outcomes in organ transplantation. Prog Transplant. 2000 Dec;10(4):239-59; quiz 260-1. doi: 10.1177/152692480001000408.
- Switzer GE, Dew MA, Goycoolea JM, Myaskovsky L, Abress L, Confer DL. Attrition of potential bone marrow donors at two key decision points leading to donation. Transplantation. 2004 May 27;77(10):1529-34. doi: 10.1097/01.tp.0000122219.35928.d6.
- Myaskovsky L, Switzer GE, Dew MA, Goycoolea JM, Confer DL, Abress L. The association of donor center characteristics with attrition from the national marrow donor registry. Transplantation. 2004 Mar 27;77(6):874-80. doi: 10.1097/01.tp.0000116394.88804.a7.
Study record dates
Study Major Dates
Study Start
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 5101
- R29HL056901 (U.S. NIH Grant/Contract)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Blood Disease
-
Assistance Publique Hopitaux De MarseilleNot yet recruitingBlood Platelet Disease
-
University of New MexicoNational Heart, Lung, and Blood Institute (NHLBI)TerminatedBlood Disease | Blood Donors
-
National Heart, Lung, and Blood Institute (NHLBI)CompletedHeart Diseases | Cardiovascular Diseases | Lung Diseases | Blood Disease
-
University of UlsterCompletedBlood PressureUnited Kingdom
-
Azienda Ospedaliera San Giovanni BattistaUnknown
-
University of Wisconsin, MadisonUniversity of Wisconsin Carbone Cancer Center (UWCCC)Not yet recruiting
-
Hamad Medical CorporationSidra Medical and Research Center; World Anti-Doping Agency; Anti-Doping Lab... and other collaboratorsUnknownBlood Disease | Blood Transfusion, Autologous | Blood Doping | Blood Transfusion, HomologousQatar
-
Archemix Corp.Withdrawn
-
Uniform Data System for Medical RehabilitationTerminatedNervous System Diseases | Wounds and Injuries | Heart and Blood Disease | Muscle, Bone and Cartilage Disease | Skin and Connective Tissue DiseaseUnited States
-
National Heart, Lung, and Blood Institute (NHLBI)CompletedAnemia | Blood Disease