- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00328666
The Penn Lifestyle Modification and Blood Pressure Study
November 24, 2015 updated by: University of Pennsylvania
Cardiovascular Effects of Iyengar Yoga vs. Enhanced Usual Care in Patients With High-normal to Stage I Hypertension
The purpose of this study is to compare the effects of 12 weeks of structured classes of either iyengar yoga (IY) or an enhanced usual care intervention on blood pressure, heart rate variability, quality of life measures, lipid measures, and safety in patients with high-normal to stage I hypertension.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
This is a single site, parallel, non-blinded, randomized controlled trial to assess the safety and efficacy of 12 weeks of structured IY vs. enhanced usual care in adults with high-normal to stage I HTN.
All potential subjects will be screened first by telephone and then by an outpatient visit at the General Clinical Research Center (GCRC) at either the hospital of the University of Pennsylvania (HUP) or the Presbyterian Medical Center (PMC).
Eligible subjects will then make 4 visits to the GCRC where, during 3 visits, they will be admitted overnight to have non-invasive 24 hour recordings of blood pressure and heart rate variability as well as periodic blood and urine collections.
In order to assess durability of biologic effects once the formal intervention is stopped, we added a 4 week follow up visit.
The entire study duration is 18 weeks (16 weeks post-randomization) and includes a total of 5 visits.
Subjects will be randomized to either the IYP or Blood Pressure Education Program (BPEP) which will be incorporated into off-site, small group classes.
Study Type
Interventional
Enrollment
60
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
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Pennsylvania
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Philadelphia, Pennsylvania, United States, 19104
- University of Pennsylvania
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-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 70 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Subjects must be willing to, and have the capacity for, giving written informed consent.
- Between the ages of 18 and 70
- Blood pressure (BP) criteria: systolic blood pressure (SBP) of > 130 but < 160 mm Hg and diastolic blood pressure (DBP) < 100 mmHg
- All subjects must be willing to comply with all study-related procedures.
Exclusion Criteria:
- Female subjects who are pregnant or post partum < 3 months
- Subjects currently taking blood pressure lowering medications or dietary supplements (magnesium, potassium, calcium > 1200 mg/day, fish oils > 2000 mg/day, ephedra, hawthorn, forskolin)
- Non-dominant arm circumference > 50 cm
- Subjects with body mass index (BMI) >= 40.0 or < 18.5 kg/m2
- Subjects who have practiced IY in the last 12 months or those who have practiced any form of yoga > 2 times (2x)/month in the previous 6 months.
- Subjects who have received an experimental drug, used an experimental medical device within 30 days prior to screening, or who gave a blood donation of greater than or equal to one pint within 8 weeks prior to screening.
- Subjects with diabetes mellitus
- Subjects with established cardiovascular disease
- Subjects with known arrhythmias such as atrial flutter or fibrillation or those with cardiac pacemakers
- Current users (within the previous 30 days) of any tobacco products
- History of renal insufficiency based on estimated glomerular filtration rate < 60 ml/min
- Women who consume > 10 alcoholic drinks per week and men who consume > 15 drinks per week.
- Subjects with known autonomic neuropathy (e.g: Shy-Drager, orthostatic hypotension)
- Subjects with known secondary causes of hypertension (renal artery stenosis, pheochromocytoma, coarctation of aorta, hyperaldosteronemia)
- Regular use of benzodiazepines, anti-psychotic drugs or corticosteroids (> 1x per month). Stable doses (3 months) of antidepressants (selective serotonin reuptake inhibitors [SSRIs] or tricyclic antidepressants [TCAs]) will be allowed.
- Known severe musculoskeletal problems such as spinal stenosis that may limit participation in yoga
- Subjects who actively practice (> 2x/month) other mind-body therapy (MBT) such as Qigong, Tai Chi, or meditation.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
---|
systolic blood pressure
|
Secondary Outcome Measures
Outcome Measure |
---|
lipids
|
heart rate variability
|
safety markers
|
quality of life measures
|
physiologic markers of stress
|
insulin resistance
|
pulse wave velocity
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Principal Investigator: Raymond Townsend, MD, University of Pennsylvania
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
February 1, 2005
Primary Completion (Actual)
January 1, 2007
Study Completion (Actual)
January 1, 2007
Study Registration Dates
First Submitted
May 18, 2006
First Submitted That Met QC Criteria
May 18, 2006
First Posted (Estimate)
May 22, 2006
Study Record Updates
Last Update Posted (Estimate)
November 25, 2015
Last Update Submitted That Met QC Criteria
November 24, 2015
Last Verified
November 1, 2015
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 802058 LIMBS
- NIH grant number AT002353-02
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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