- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00353041
A Study of the Effect of Time on Topical Anesthetic Efficacy.
July 13, 2006 updated by: University of Toronto
This is a study of the effect of time on the effectiveness of topical anesthetics in the mouth.
The Null Hypothesis is: Regardless of the time of application over a 10-minute period, there is no difference in the clinical effectiveness of the topical anesthetic 5% lidocaine on (a) the pain of needle stick insertion and (b) the pain of local anaesthetic administration.
Study Overview
Detailed Description
The study design will be a double blind randomized controlled split-mouth clinical trial.
It is proposed to compare the effectiveness of the standard topical anesthetic 5% lidocaine with a placebo over the time period of 2, 5 and 10 minutes after application.
The topical will be placed on the palatal soft tissue where the perception of pain is the highest in the oral cavity.
Both the pain of needle insertion and the pain of local anesthetic injection will be compared.
Study Type
Interventional
Enrollment
90
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Jasdev Bhalla, BDS
- Phone Number: 4325 4169794922
- Email: drjasdev@yahoo.com
Study Locations
-
-
Ontario
-
Toronto, Ontario, Canada, M5G 1G6
- Recruiting
- Faculty of Dentistry
-
Contact:
- Jasdev Bhalla, BDS
- Phone Number: 4325 416-979-4922
- Email: drjasdev@yahoo.com
-
Principal Investigator:
- Jasdev Bhalla, BDS
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 70 years (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- In good health (ASA 1 or ASA 2)
- Weight between 40-100kg, inclusive.
- Between ages 18-70, inclusive.
- Informed consent
Exclusion Criteria:
- ASA 3 or higher.
- History of allergy to sulfites, lidocaine or mepivacaine.
- Taking any analgesic 48hrs before testing, such as an NSAID, opioid, or acetaminophen.
- Pregnancy.
- Recent oral trauma.
- Lack of informed consent.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Educational/Counseling/Training
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Double
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
---|
pain
|
Secondary Outcome Measures
Outcome Measure |
---|
Heart rate
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Daniel A Haas, DDS, PhD, University of Toronto
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
July 1, 2006
Study Completion
December 1, 2006
Study Registration Dates
First Submitted
July 13, 2006
First Submitted That Met QC Criteria
July 13, 2006
First Posted (Estimate)
July 17, 2006
Study Record Updates
Last Update Posted (Estimate)
July 17, 2006
Last Update Submitted That Met QC Criteria
July 13, 2006
Last Verified
July 1, 2006
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Physiological Effects of Drugs
- Molecular Mechanisms of Pharmacological Action
- Anti-Arrhythmia Agents
- Central Nervous System Depressants
- Peripheral Nervous System Agents
- Sensory System Agents
- Anesthetics
- Membrane Transport Modulators
- Anesthetics, Local
- Voltage-Gated Sodium Channel Blockers
- Sodium Channel Blockers
- Lidocaine
Other Study ID Numbers
- UToronto
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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