- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03096444
Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine
June 24, 2019 updated by: Gil Yosipovitch
The purpose of this study is to examine the antipruritic efficacy of topical ketamine, amitriptyline, lidocaine, and a tri-combination of ketamine, amitriptyline and lidocaine (hereafter referred to as "KeAmLi") using non-histaminergic itch provocations in healthy volunteers.
The primary outcome is itch reduction (AUC) between the vehicle and active treatment (KeAmLi-combo).
Secondary outcomes include modality-specific analgesic properties of the topically applied ketamine, amitriptyline, lidocaine, and KeAmLi-combo to controlled quantitative thermal and mechanical stimuli, which can improve our understanding of the mechanism of action of these substances in the context of topical therapy.
Study Overview
Status
Terminated
Conditions
Detailed Description
This is a double-blind, vehicle-controlled study to evaluate the antipruritic efficacy of topical ketamine, amitriptyline, lidocaine, and a tri-combination of ketamine, amitriptyline and lidocaine (hereafter referred to as "KeAmLi") using non-histaminergic itch provocations in healthy volunteers.
Each participant will be pre-treated with the vehicle and 4 active topical creams, over two study visits (3 treatments on the 1st visit and 2 treatment on the 2nd visit).
Each treatment will be applied to the randomized forearm test area for 30 minute, and then sensory testing will be performed.
Sensory testing includes thermal and mechanical stimuli, and itch induction using the plant cowhage.
These tests will reveal mechanistic information and potential cellular and molecular targets for improved antipruritic and analgesic therapies.
Study Type
Interventional
Enrollment (Actual)
13
Phase
- Phase 2
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Florida
-
Miami, Florida, United States, 33136
- University of Miami
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 50 years (Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Healthy subjects (absence of disease) between 18 and 50 years of age.
- Must be in general good health with no disease or physical conditions that would impair evaluation of itch and pain perception.
- No history of chronic itch or pain.
- Must abstain from the use of any systemic or topical anti-histamine, steroid, or pain relief medications 48 hours prior to the study visits.
- Must abstain from the use of moisturizers on the arms the day of study visit.
Exclusion Criteria:
- Individuals under 18 or over 50 years of age.
- Inability to complete the required measures.
- The presence of an itchy skin disease or a painful condition.
- Diagnosis of diseased that would affect itch or pain perception (e.g. neuropathies).
- Currently enrolled in any investigational study in which the subject is receiving any type of drug, biological, or non-drug therapy.
- Use of oral, topical analgesics, or other medications known to interfere with itch or pain perception 48 hours prior to the study visits (e.g. antihistamines, anesthetics, anti-inflammatories, opioids, neuroleptics, etc.).
- Use of emollients on the volar aspects of the forearms arms on the day of the study visit.
- Use of anti-depressants, anti-psychotics, and illicit drugs.
- Known history of neuropathy, uremia, uncontrolled thyroid disease, and diabetes mellitus.
- Known history of anaphylactic shock, or allergy to cowhage and/or known adverse reactions to lidocaine (or other local anesthetics of the amide type), ketamine or amitriptyline.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Topical KeAmLi combo
Topical KeAmLi-combo (ketamine 10%, amitriptyline 5%, and lidocaine 5%) will be applied to one four 4 x 4 cm predefined skin areas on the ventral forearms during one of two study visits.
The pre-treatment will occur under topical occlusion for 30 minutes to allow the ointment to be adsorbed.
Following this, residual ointment will be removed and sensory testing, strictly within the pretreated area, will commence.
|
2g of topical KeAmLi-combo (ketamine 10%, amitriptyline 5%, and lidocaine 5%) will be applied for 30 minutes on one 4x4cm area on the volar forearm in one of two study visits.
Other Names:
|
Experimental: Topical ketamine
Topical ketamine 10% will be applied to one four 4 x 4 cm predefined skin areas on the ventral forearms during one of two study visits.
The pre-treatment will occur under topical occlusion for 30 minutes to allow the ointment to be adsorbed.
Following this, residual ointment will be removed and sensory testing, strictly within the pretreated area, will commence.
|
2g of topical 10% Ketamine will be applied for 30 minutes on one 4x4cm area on the volar forearm in one of two study visits.
Other Names:
|
Experimental: Topical amitriptyline
Topical amitriptyline 5% will be applied to one four 4 x 4 cm predefined skin areas on the ventral forearms during one of two study visits.
The pre-treatment will occur under topical occlusion for 30 minutes to allow the ointment to be adsorbed.
Following this, residual ointment will be removed and sensory testing, strictly within the pretreated area, will commence.
|
2g of topical 5% Amitriptyline will be applied for 30 minutes on one 4x4cm area on the volar forearm in one of two study visits.
Other Names:
|
Experimental: Topical lidocaine
Topical lidocaine 5% will be applied to one four 4 x 4 cm predefined skin areas on the ventral forearms during one of two study visits.
The pre-treatment will occur under topical occlusion for 30 minutes to allow the ointment to be adsorbed.
Following this, residual ointment will be removed and sensory testing, strictly within the pretreated area, will commence.
|
2g of topical 5% Lidocaine will be applied for 30 minutes on one 4x4cm area on the volar forearm in one of two study visits.
Other Names:
|
Placebo Comparator: Topical vehicle
Topical vehicle (PCCA Lipoderm) will be applied to one four 4 x 4 cm predefined skin areas on the ventral forearms during one of two study visits.
The pre-treatment will occur under topical occlusion for 30 minutes to allow the ointment to be adsorbed.
Following this, residual ointment will be removed and sensory testing, strictly within the pretreated area, will commence.
|
2g of topical vehicle (Lipoderm) will be applied for 30 minutes on one 4x4cm area on the volar forearm in one of two study visits.
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Peak Itch Intensity Between the Vehicle and Active Treatments (Individual and KeAmLi-combo).
Time Frame: 10 minutes
|
Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo).
Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes.
0 was weighted with "no itch" and 100 was weighted with "most itch imaginable".
|
10 minutes
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Thermal Threshold Detection (Warmth and Heat Pain)
Time Frame: 3 minutes
|
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected).
Measured in change in celsius.
|
3 minutes
|
Mechanical Thresholds (Mechanical Detection and Pain).
Time Frame: 5 minutes
|
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli.
|
5 minutes
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Rolke R, Baron R, Maier C, Tolle TR, Treede -DR, Beyer A, Binder A, Birbaumer N, Birklein F, Botefur IC, Braune S, Flor H, Huge V, Klug R, Landwehrmeyer GB, Magerl W, Maihofner C, Rolko C, Schaub C, Scherens A, Sprenger T, Valet M, Wasserka B. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values. Pain. 2006 Aug;123(3):231-243. doi: 10.1016/j.pain.2006.01.041. Epub 2006 May 11. Erratum In: Pain. 2006 Nov;125(1-2):197.
- Carroll CL, Balkrishnan R, Feldman SR, Fleischer AB Jr, Manuel JC. The burden of atopic dermatitis: impact on the patient, family, and society. Pediatr Dermatol. 2005 May-Jun;22(3):192-9. doi: 10.1111/j.1525-1470.2005.22303.x.
- Lynch ME, Clark AJ, Sawynok J, Sullivan MJ. Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial. Anesthesiology. 2005 Jul;103(1):140-6. doi: 10.1097/00000542-200507000-00021.
- Reddy VB, Iuga AO, Shimada SG, LaMotte RH, Lerner EA. Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors. J Neurosci. 2008 Apr 23;28(17):4331-5. doi: 10.1523/JNEUROSCI.0716-08.2008.
- Papoiu AD, Tey HL, Coghill RC, Wang H, Yosipovitch G. Cowhage-induced itch as an experimental model for pruritus. A comparative study with histamine-induced itch. PLoS One. 2011 Mar 14;6(3):e17786. doi: 10.1371/journal.pone.0017786.
- Taddio A, Ohlsson A, Einarson TR, Stevens B, Koren G. A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates. Pediatrics. 1998 Feb;101(2):E1. doi: 10.1542/peds.101.2.e1.
- Gammaitoni AR, Alvarez NA, Galer BS. Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature. J Clin Pharmacol. 2003 Feb;43(2):111-7. doi: 10.1177/0091270002239817.
- Weisshaar E, Gieler U, Kupfer J, Furue M, Saeki H, Yosipovitch G; International Forum on the Study of Itch. Questionnaires to assess chronic itch: a consensus paper of the special interest group of the International Forum on the Study of Itch. Acta Derm Venereol. 2012 Sep;92(5):493-6. doi: 10.2340/00015555-1402.
- Matterne U, Apfelbacher CJ, Vogelgsang L, Loerbroks A, Weisshaar E. Incidence and determinants of chronic pruritus: a population-based cohort study. Acta Derm Venereol. 2013 Sep 4;93(5):532-7. doi: 10.2340/00015555-1572.
- Matterne U, Apfelbacher CJ, Loerbroks A, Schwarzer T, Buttner M, Ofenloch R, Diepgen TL, Weisshaar E. Prevalence, correlates and characteristics of chronic pruritus: a population-based cross-sectional study. Acta Derm Venereol. 2011 Oct;91(6):674-9. doi: 10.2340/00015555-1159.
- Leknes SG, Bantick S, Willis CM, Wilkinson JD, Wise RG, Tracey I. Itch and motivation to scratch: an investigation of the central and peripheral correlates of allergen- and histamine-induced itch in humans. J Neurophysiol. 2007 Jan;97(1):415-22. doi: 10.1152/jn.00070.2006. Epub 2006 Aug 16.
- Wahlgren CF. Itch and atopic dermatitis: an overview. J Dermatol. 1999 Nov;26(11):770-9. doi: 10.1111/j.1346-8138.1999.tb02090.x.
- Brenaut E, Garlantezec R, Talour K, Misery L. Itch characteristics in five dermatoses: non-atopic eczema, atopic dermatitis, urticaria, psoriasis and scabies. Acta Derm Venereol. 2013 Sep 4;93(5):573-4. doi: 10.2340/00015555-1599. No abstract available.
- Patel T, Yosipovitch G. Therapy of pruritus. Expert Opin Pharmacother. 2010 Jul;11(10):1673-82. doi: 10.1517/14656566.2010.484420.
- Kopsky DJ, Keppel Hesselink JM, Bhaskar A, Hariton G, Romanenko V, Casale R. Analgesic effects of topical ketamine. Minerva Anestesiol. 2015 Apr;81(4):440-9. Epub 2014 May 22.
- Coggeshall RE, Carlton SM. Ultrastructural analysis of NMDA, AMPA, and kainate receptors on unmyelinated and myelinated axons in the periphery. J Comp Neurol. 1998 Feb 2;391(1):78-86. doi: 10.1002/(sici)1096-9861(19980202)391:13.3.co;2-8.
- Carlton SM, Coggeshall RE. Inflammation-induced changes in peripheral glutamate receptor populations. Brain Res. 1999 Feb 27;820(1-2):63-70. doi: 10.1016/s0006-8993(98)01328-6.
- Davidson EM, Coggeshall RE, Carlton SM. Peripheral NMDA and non-NMDA glutamate receptors contribute to nociceptive behaviors in the rat formalin test. Neuroreport. 1997 Mar 3;8(4):941-6. doi: 10.1097/00001756-199703030-00025.
- Mehta AK, Halder S, Khanna N, Tandon OP, Singh UR, Sharma KK. Role of NMDA and opioid receptors in neuropathic pain induced by chronic constriction injury of sciatic nerve in rats. J Basic Clin Physiol Pharmacol. 2012;23(2):49-55. doi: 10.1515/jbcpp-2012-0003.
- Zhou S, Bonasera L, Carlton SM. Peripheral administration of NMDA, AMPA or KA results in pain behaviors in rats. Neuroreport. 1996 Mar 22;7(4):895-900. doi: 10.1097/00001756-199603220-00012.
- Tandon OP, Mehta AK, Halder S, Khanna N, Sharma KK. Peripheral interaction of opioid and NMDA receptors in inflammatory pain in rats. Indian J Physiol Pharmacol. 2010 Jan-Mar;54(1):21-31.
- Sandroni P, Davis MD. Combination gel of 1% amitriptyline and 0.5% ketamine to treat refractory erythromelalgia pain: a new treatment option? Arch Dermatol. 2006 Mar;142(3):283-6. doi: 10.1001/archderm.142.3.283. No abstract available.
- Gerner P, Kao G, Srinivasa V, Narang S, Wang GK. Topical amitriptyline in healthy volunteers. Reg Anesth Pain Med. 2003 Jul-Aug;28(4):289-93. doi: 10.1016/s1098-7339(03)00209-8.
- Lynch ME, Clark AJ, Sawynok J, Sullivan MJ. Topical amitriptyline and ketamine in neuropathic pain syndromes: an open-label study. J Pain. 2005 Oct;6(10):644-9. doi: 10.1016/j.jpain.2005.04.008.
- Uzaraga I, Gerbis B, Holwerda E, Gillis D, Wai E. Topical amitriptyline, ketamine, and lidocaine in neuropathic pain caused by radiation skin reaction: a pilot study. Support Care Cancer. 2012 Jul;20(7):1515-24. doi: 10.1007/s00520-011-1240-7. Epub 2011 Aug 17.
- Griffin JR, Davis MD. Amitriptyline/Ketamine as therapy for neuropathic pruritus and pain secondary to herpes zoster. J Drugs Dermatol. 2015 Feb;14(2):115-8.
- Lynch ME, Clark AJ, Sawynok J. A pilot study examining topical amitriptyline, ketamine, and a combination of both in the treatment of neuropathic pain. Clin J Pain. 2003 Sep-Oct;19(5):323-8. doi: 10.1097/00002508-200309000-00007.
- LaMotte RH, Dong X, Ringkamp M. Sensory neurons and circuits mediating itch. Nat Rev Neurosci. 2014 Jan;15(1):19-31. doi: 10.1038/nrn3641.
- Sawynok J. Topical analgesics for neuropathic pain in the elderly: current and future prospects. Drugs Aging. 2014 Dec;31(12):853-62. doi: 10.1007/s40266-014-0218-9.
- Schmelz M, Schmidt R, Bickel A, Handwerker HO, Torebjork HE. Specific C-receptors for itch in human skin. J Neurosci. 1997 Oct 15;17(20):8003-8. doi: 10.1523/JNEUROSCI.17-20-08003.1997.
- Abels C. Intra-epidermal nerve fibres in human skin: back to the roots. Exp Dermatol. 2014 Apr;23(4):232-3. doi: 10.1111/exd.12326. Epub 2014 Feb 16.
- Zylka MJ, Rice FL, Anderson DJ. Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron. 2005 Jan 6;45(1):17-25. doi: 10.1016/j.neuron.2004.12.015.
- Namer B, Carr R, Johanek LM, Schmelz M, Handwerker HO, Ringkamp M. Separate peripheral pathways for pruritus in man. J Neurophysiol. 2008 Oct;100(4):2062-9. doi: 10.1152/jn.90482.2008. Epub 2008 Jun 18.
- Stander S, Schmelz M. Chronic itch and pain--similarities and differences. Eur J Pain. 2006 Jul;10(5):473-8. doi: 10.1016/j.ejpain.2006.03.005. Epub 2006 May 5.
- Tey HL, Yosipovitch G. Targeted treatment of pruritus: a look into the future. Br J Dermatol. 2011 Jul;165(1):5-17. doi: 10.1111/j.1365-2133.2011.10217.x. Epub 2011 May 30.
- Hoeck EA, Marker JB, Gazerani P, H Andersen H, Arendt-Nielsen L. Preclinical and human surrogate models of itch. Exp Dermatol. 2016 Oct;25(10):750-7. doi: 10.1111/exd.13078.
- Andersen HH, Sorensen AR, Nielsen GA, Molgaard MS, Stilling P, Boudreau SA, Elberling J, Arendt-Nielsen L. A Test-Retest Reliability Study of Human Experimental Models of Histaminergic and Non-histaminergic Itch. Acta Derm Venereol. 2017 Feb 8;97(2):198-207. doi: 10.2340/00015555-2502.
- Sikand P, Shimada SG, Green BG, LaMotte RH. Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage. Pain. 2009 Jul;144(1-2):66-75. doi: 10.1016/j.pain.2009.03.001. Epub 2009 May 6.
- LaMotte RH, Shimada SG, Green BG, Zelterman D. Pruritic and nociceptive sensations and dysesthesias from a spicule of cowhage. J Neurophysiol. 2009 Mar;101(3):1430-43. doi: 10.1152/jn.91268.2008. Epub 2009 Jan 14.
- Sikand P, Shimada SG, Green BG, LaMotte RH. Sensory responses to injection and punctate application of capsaicin and histamine to the skin. Pain. 2011 Nov;152(11):2485-2494. doi: 10.1016/j.pain.2011.06.001. Epub 2011 Jul 29.
- Papoiu AD, Coghill RC, Kraft RA, Wang H, Yosipovitch G. A tale of two itches. Common features and notable differences in brain activation evoked by cowhage and histamine induced itch. Neuroimage. 2012 Feb 15;59(4):3611-23. doi: 10.1016/j.neuroimage.2011.10.099. Epub 2011 Nov 12.
- Rolke R, Magerl W, Campbell KA, Schalber C, Caspari S, Birklein F, Treede RD. Quantitative sensory testing: a comprehensive protocol for clinical trials. Eur J Pain. 2006 Jan;10(1):77-88. doi: 10.1016/j.ejpain.2005.02.003.
- Maier C, Baron R, Tolle TR, Binder A, Birbaumer N, Birklein F, Gierthmuhlen J, Flor H, Geber C, Huge V, Krumova EK, Landwehrmeyer GB, Magerl W, Maihofner C, Richter H, Rolke R, Scherens A, Schwarz A, Sommer C, Tronnier V, Uceyler N, Valet M, Wasner G, Treede DR. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes. Pain. 2010 Sep;150(3):439-450. doi: 10.1016/j.pain.2010.05.002.
- Mainka T, Malewicz NM, Baron R, Enax-Krumova EK, Treede RD, Maier C. Presence of hyperalgesia predicts analgesic efficacy of topically applied capsaicin 8% in patients with peripheral neuropathic pain. Eur J Pain. 2016 Jan;20(1):116-29. doi: 10.1002/ejp.703. Epub 2015 Apr 8.
- Tam E, Furlan AD. Transdermal lidocaine and ketamine for neuropathic pain: a study of effectiveness and tolerability. Open Neurol J. 2012;6:58-64. doi: 10.2174/1874205X01206010058. Epub 2012 Jun 28.
- Gammaitoni A, Gallagher RM, Welz-Bosna M. Topical ketamine gel: possible role in treating neuropathic pain. Pain Med. 2000 Mar;1(1):97-100. doi: 10.1046/j.1526-4637.2000.00006.x.
- Sullivan RW, Ryzewski M, Holland MG, Marraffa JM. Compounded ointment results in severe toxicity in a pediatric patient. Pediatr Emerg Care. 2013 Nov;29(11):1220-2. doi: 10.1097/PEC.0b013e3182aa4748.
- Jackson D, Chen AH, Bennett CR. Identifying true lidocaine allergy. J Am Dent Assoc. 1994 Oct;125(10):1362-6. doi: 10.14219/jada.archive.1994.0180.
- Selcuk E, Erturk S, Afrashi A. An adverse reaction to local anaesthesia: report of a case. Dent Update. 1996 Oct;23(8):345-6.
- Friedman PM, Mafong EA, Friedman ES, Geronemus RG. Topical anesthetics update: EMLA and beyond. Dermatol Surg. 2001 Dec;27(12):1019-26. doi: 10.1046/j.1524-4725.2001.01855.x.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
May 23, 2017
Primary Completion (Actual)
July 19, 2017
Study Completion (Actual)
July 21, 2017
Study Registration Dates
First Submitted
March 16, 2017
First Submitted That Met QC Criteria
March 24, 2017
First Posted (Actual)
March 30, 2017
Study Record Updates
Last Update Posted (Actual)
July 2, 2019
Last Update Submitted That Met QC Criteria
June 24, 2019
Last Verified
April 1, 2019
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Skin Diseases
- Skin Manifestations
- Pruritus
- Physiological Effects of Drugs
- Adrenergic Agents
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Anti-Arrhythmia Agents
- Central Nervous System Depressants
- Peripheral Nervous System Agents
- Analgesics
- Sensory System Agents
- Anesthetics, Dissociative
- Anesthetics, Intravenous
- Anesthetics, General
- Anesthetics
- Excitatory Amino Acid Antagonists
- Excitatory Amino Acid Agents
- Analgesics, Non-Narcotic
- Psychotropic Drugs
- Neurotransmitter Uptake Inhibitors
- Membrane Transport Modulators
- Antidepressive Agents
- Antidepressive Agents, Tricyclic
- Anesthetics, Local
- Voltage-Gated Sodium Channel Blockers
- Sodium Channel Blockers
- Adrenergic Uptake Inhibitors
- Ketamine
- Lidocaine
- Amitriptyline
Other Study ID Numbers
- 20170087
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Yes
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Pruritus
-
Kissei Pharmaceutical Co., Ltd.Completed
-
Toray Industries, IncCompletedUremic PruritusBulgaria, Germany
-
Cara Therapeutics, Inc.CompletedPruritus | Uremic PruritusUnited States
-
Thammasat University HospitalCompletedUremic PruritusThailand
-
Conmed Pharmaceutical & Bio-Medical CorporationChang Gung Memorial Hospital; Kaohsiung Medical University; Tri-Service General... and other collaboratorsCompleted
-
Haisco Pharmaceutical Group Co., Ltd.Completed
-
Kissei Pharmaceutical Co., Ltd.Maruishi PharmaceuticalCompleted
-
Chang Gung Memorial HospitalUnknown
-
Lumosa Therapeutics Co., Ltd.Unknown
-
RDD Pharma LtdWithdrawn
Clinical Trials on Ketamine hydrochloride, Amitriptyline hydrochloride, and Lidocaine hydrochloride
-
Rajmonda Nallbani-KomoniUnknownAnalgesic Drug DependenceKosovo
-
Ciusss de L'Est de l'Île de MontréalRecruiting
-
Cairo UniversityUnknownSeptic Shock | AnesthesiaEgypt
-
National Institute of Allergy and Infectious Diseases...CompletedHIV Infections | Peripheral Nervous System DiseaseUnited States
-
Xijing Hospital of Digestive DiseasesCompleted
-
Xijing Hospital of Digestive DiseasesCompletedColorectal AdenomasChina
-
Shenyang Sunshine Pharmaceutical Co., LTD.UnknownUremic PruritusChina
-
Case Comprehensive Cancer CenterActive, not recruitingOpioid Consumption | Postoperative Pain ControlUnited States
-
M.D. Anderson Cancer CenterWithdrawnMetastatic Lung Non-Small Cell Carcinoma | Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8
-
First Affiliated Hospital of Zhejiang UniversityHunan DongtingPharm.Co.LtdCompleted