Visual Motor Coordination

Background:

• The relation between eye movement and brain function is a subject of interest to the National Eye Institute.
• By comparing eye movement in healthy volunteers to research conducted on patients who have difficulty moving their eyes, the National Eye Institute hopes to develop and improve diagnostic procedures for people with eye diseases.

Objectives:

-The purpose of this study is to understand how we see visual patterns and how we move our eyes to see.

Eligibility:

• Normal volunteers:

  • must have no serious illnesses and must be 18 years of age or older
  • are able to follow directions and pay attention to visual stimuli and respond as appropriate
  • individuals with a history of eye or brain diseases, or previous eye or eye muscle surgery, are not allowed to participate in this study. Individuals who are currently using eye medications also are not eligible for the study.

• Patients:

  • who are 18 years of age or older
  • are able to follow directions and pay attention to visual stimuli and respond as appropriate

Design:

• Participants will visit the National Eye Institute outpatient clinic for examination and testing.
• Participants will be screened with a medical history and eye examination (including eye pressure and eye movement tests).

• Participants with healthy eyes will participate in eye movement testing experiments:

  • One or more sessions lasting less than three hours each.
  • Eye movements will be recorded with a video/infrared camera system.
  • For the majority of the studies done under this protocol, only one or two sessions will be required. A few studies recording very small eye movements will require three or more sessions.

Study Overview

• Status: Terminated
• Conditions: Neurodegenerative Diseases; Healthy Volunteer

Detailed Description

Study Description: This natural history study will investigate eye movements and other responses to visual stimuli in normal individuals (normal volunteers) and patients. Normal adult volunteers will be recruited and will undergo an eye exam to assure that there are no visual system problems. . Volunteers will be studied in one or more sessions where eye movement, verbal, or hand movement responses are recorded in response to visual stimuli. Patients with diseases affecting the oculomotor or visual systems will also be recruited to help us better understand these systems and to help characterize their specific disease.

Objectives:

The objective is to study normal volunteers and patients for eye movement and other responses to visual stimuli with the goal of better understanding human vision and neural control of eye movements.

Endpoints:

The primary outcome measure is eye movement and other responses to visual stimuli.

• Study Type: Observational
• Enrollment (Actual): 34

Contacts and Locations

Study Locations

• United States
  • Maryland
    • Bethesda, Maryland, United States, 20892
      • National Institutes of Health Clinical Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

normal adult volunteers and patients with eye movement problems including strabismus or neuro-degeneration.

Description

• INCLUSION CRITERIA:

Inclusion Criteria for Normal Volunteers:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

1. Participant must be a volunteer with no ocular, visual, or oculomotor problems.
2. Participant must be 18 years old or older.
3. Participant must be able to follow directions and actively pay attention to visual stimuli and respond as appropriate.
4. For studies which use the contact lens, participant must be able to tolerate a contact lens in either one or both eyes.

Inclusion Criteria for Patients:

In order to be eligible to participate in this study, an individual must meet all of the following criteria

1. Participant must be 18 years old or older.
2. Participant must be able to follow directions and actively pay attention to visual stimuli and respond as appropriate.
3. For studies which use the contact lens, participant must be able to tolerate a contact lens in either one or both eyes.

EXCLUSION CRITERIA:

Exclusion Criteria for Normal Volunteers:

An individual who meets any of the following criteria will be excluded from participation in this

study:

An individual who meets any of the following criteria will be excluded from participation in thisstudy:

1. Participant has a history of ocular or visual diseases or diseases affecting the nervous system (including myasthenia, MS, etc.) or any diseases which might affect control of eye movements or affect vision.
2. Participant has had prior eye or eye muscle surgery.
3. Participant has a history of eye patching (amblyopia or lazy eye).
4. Participant currently uses eye drops or ocular medications.

Exclusion Criteria for Patients:

An individual who meets any of the following criteria will be excluded from participation in this study:

1. Patient is unable to cooperate with testing, including sitting still while eye movements are recorded.

Study Plan

How is the study designed?

Design Details

• Observational Models: Case-Only
• Time Perspectives: Prospective

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Normal Volunteer; Healthy subjects without neurodegenerative diseases
Patients; Subjects with neurodegenerative diseases

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
eye movement/responses to visual stimuli	Analysis of eye movements to characterize basic processes (normal volunteers) and to judge disease progress (in patients)	one to many times depending if normal volunteer or patient and the number of trials required to achieve clean data for small eye movements.

Collaborators and Investigators

• Sponsor: National Eye Institute (NEI)
• Investigators: Principal Investigator: Rich J Krauzlis, Ph.D., National Eye Institute (NEI)

Publications and helpful links

Helpful Links

• NIH Clinical Center Detailed Web Page

Study record dates

Study Major Dates

• Study Start (Actual): December 4, 2007
• Primary Completion (Actual): April 9, 2024
• Study Completion (Actual): April 9, 2024

Study Registration Dates

• First Submitted: December 4, 2007
• First Submitted That Met QC Criteria: December 4, 2007
• First Posted (Estimated): December 5, 2007

Study Record Updates

• Last Update Posted (Actual): April 12, 2024
• Last Update Submitted That Met QC Criteria: April 11, 2024
• Last Verified: April 1, 2024

More Information

Terms related to this study

• Keywords: HV; Natural History; Healthy Volunteer; Saccades; Reaction Time; Eye Movements; Visuomotor Integration; Visual Attention
• Additional Relevant MeSH Terms: Nervous System Diseases; Neurodegenerative Diseases
• Other Study ID Numbers: 080031; 08-EI-0031

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: .The raw data is eye movement tracings which are of no utility except in the context of a study with multiple subjects. Obtained results will be published and if requested, original data will be shared.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No