Evaluation of the MRI in Measuring the Cardiac Chambers and Thoracic Great Vessels

Optimized MRI Evaluation of Maximal Temporal and Spatial Measurability of the Cardiac Chambers and Thoracic Great Vessels. A Comparison of MR Acquisition Pulse Sequences.

We are seeking volunteers to participate in a research study to determine the optimal imaging parameters for visualization of the heart and its great vessels so that errors in computer data analysis is minimized and clinical accuracy is maximized.

Participation in this study will involve having an MRI of the heart. This study will allow us to determine the ability to measure the volumes of your heart chambers in both the left and right side of your heart without using any aggressive (invasive) technique or the use of ionizing radiation (x-rays or gamma rays). The study will also allow us to measure changes in the cardiac chamber volumes during the cardiac cycle and determine whether this can be done rapidly and accurately. The study will also allow us to determine whether this technique can be used for routine clinical use.

Study Overview

• Status: Completed
• Conditions: Cardiac Chambers

Detailed Description

The ability to obtain accurate cyclical functional information of the cardiac chambers plays a continuing important clinical diagnostic role in the evaluation and monitoring of patients with a wide range of cardiac pathologies, including those embarking on or continuing cardiotoxic chemotherapeutic regimes, as well as patients with lung disease.

The current imaging modalities used for non-invasive imaging of the heart include echocardiography and radionuclide ventriculography. Echocardiographic evaluation of cardiac function is primarily limited to the left ventricle and functional measurements are based on volumetric estimates in turn based usually on geometric assumptions. That is, the volume calculation is based on a limited number of non orthogonal linear measurements assuming a regular (non complex) chamber morphology. This study technique provides no biologic hazard to the patient.

Radionuclide ventriculography does allow for 3D cardiac data acquisition and theoretical evaluation of biventricular function. However, the technique does not provide the same degree of spatial resolution that echocardiography can provide. Radionuclide ventriculography is a commonly accepted diagnostic procedure but does involve use of ionizing radiation.

Magnetic Resonance imaging techniques (of the heart) allows relatively high resolution cross sectional imaging. For example a 512X512 matrix over a 40cm field of view provides in plane resolution better that 1mm. No assumptions are made in regard chamber cross sectional area and hence volume morphology. The slice thickness is determined in advance and may be in the range of 1-10mm. MR data ca be acquired sequentially throughout the cardiac cycle and thus provide a time varying 3D map of the cardiac chambers and related structures during the cardiac cycle.

• Study Type: Observational
• Enrollment (Actual): 31

Contacts and Locations

Study Locations

• United States
  • New York
    • Syracuse, New York, United States, 13202
      • University Radiology Associates

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

Cardiology Clinic Center Watch Website

Description

Inclusion Criteria:

• Over the age of 18 years
• Able to understand and sign consent without surrogate signature
• Subject weight is within the 300lb limit of the MR scanning table
• Subject's bodily habitus allows the subject to fit within the MR bore
• Subject being able to lie quiescent for a period of up to 60 minutes in a supine position
• Subject would be able to hold breath at times for periods of 15-30 seconds

Exclusion Criteria:

• Subjects with pacemakers, TENS units, metallic prostheses, metal foreign bodies such as bullets, shrapnel, metallic slivers, shavings or foreign bodies

Study Plan

How is the study designed?

Collaborators and Investigators

• Sponsor: State University of New York - Upstate Medical University
• Investigators: Principal Investigator: David Feiglin, MD, SUNY Upstate MU

Study record dates

Study Major Dates

• Study Start (Actual): May 1, 1995
• Primary Completion (Actual): March 1, 2015
• Study Completion (Actual): May 1, 2015

Study Registration Dates

• First Submitted: February 1, 2008
• First Submitted That Met QC Criteria: March 18, 2008
• First Posted (Estimated): March 19, 2008

Study Record Updates

• Last Update Posted (Actual): December 21, 2023
• Last Update Submitted That Met QC Criteria: December 20, 2023
• Last Verified: December 1, 2023

More Information

Terms related to this study

• Keywords: cardiac; conventional pulse sequences for MR; cardiac chambers and walls; cardio-thoracic vasculature; the great vessels; coronary vasculature; great vessels
• Other Study ID Numbers: SUNYUMU 3149