Safety Study of XL647 and XL147 Administered in Combination Daily in Adults With Solid Tumors

A Phase 1 Dose-Escalation Study of the Safety, Pharmacokinetics, and Pharmacodynamics of XL647 and XL147 Administered in Combination Daily to Subjects With Solid Tumors

The purpose of this study is to determine the safety, tolerability, and highest safe doses of XL647 in combination with XL147 in adults with solid tumors. XL647 is a small molecule that potently inhibits multiple receptor kinases, including EGFR, VEGFR2 (KDR), and ErbB2. XL147 is a new chemical entity that inhibits PI3 Kinase. Inactivation of PI3K has been shown to inhibit growth and induce apoptosis (programmed cell death) in tumor cells.

Study Overview

• Status: Withdrawn
• Conditions: Cancer; Breast Cancer; Non-small-cell Lung Cancer
• Intervention / Treatment: Drug: XL647; Drug: XL147

• Study Type: Interventional
• Phase: Phase 1

Contacts and Locations

Study Locations

• United States
  • New York
    • New York City, New York, United States, 10021
      • Memorial Sloan Kettering Cancer Center
  • Texas
    • San Antonio, Texas, United States, 78229
      • South Texas Accelerated Research Therapeutics

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• The subject has a histologically confirmed solid tumor that is metastatic or unresectable and is no longer responding to therapies known to prolong survival or to other standard therapies, or has disease for which no standard therapy exists.
• The subject is ≥ 18 years old.
• The subject's weight is ≥ 50 kg.
• The subject has an Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2.
• The subject has a life expectancy of ≥ 3 months.
• The subject has adequate organ and marrow function.
• The subject has a fasting plasma glucose (FPG) < 120 mg/dL at screening.
• The subject is capable of understanding and complying with the protocol and has signed the informed consent document.
• Sexually active subjects (male and female) must agree to use accepted methods of contraception during the course of the study and for 3 months after the last dose of protocol drug(s).
• Female subjects of childbearing potential must have a negative pregnancy test at screening.

• Subjects in the MTD Expansion Cohort:

  • Must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST).
  • Must have a histologically confirmed diagnosis of NSCLC (Stage IIIB or IV) OR a histologically confirmed diagnosis of metastatic breast cancer.

Exclusion Criteria:

• The subject has received cytotoxic chemotherapy (including investigational cytotoxic chemotherapy) within 3 weeks (or nitrosoureas or mitomycin C within 6 weeks) before the first dose of XL647.
• The subject has received prior treatment with a small molecule kinase inhibitor (including an investigational kinase inhibitor) within 14 days before the first dose of XL647.
• The subject has received any other type of investigational agent within 30 days before the first dose of study treatment.
• The subject has not recovered from toxicity due to prior therapy.
• The subject has had major surgery within 30 days before the first dose of study drug. Subjects must have recovered or stabilized from prior surgery.
• The subject is known to have diabetes.
• The subject is currently receiving anticoagulation with warfarin (low-dose warfarin ≤ 1mg/day, heparin, and low-molecular weight heparins are permitted).
• The subject has prothrombin time (PT)/International Normalized Ratio (INR) and /or partial thromboplastin time (PTT) test results at screening that are above 1.3 times the laboratory upper limit of normal.

• The subject has any of the following cardiac criteria:

  • Corrected QT interval (QTc) of > 0.46 seconds
  • Has a finding of left bundle branch block
  • Has important bradycardia defined as a heart rate of < 50 bpm due to sinus node dysfunction
  • Has an obligate pacemaker
  • History of sustained ventricular arrhythmias (subjects with a history of atrial arrhythmias should be discussed with the sponsor before entry into the study)
  • Family history of congenital long QT syndrome or unexplained sudden death
  • Has uncontrolled hypertension
  • Has symptomatic congestive heart failure, unstable angina, or a myocardial infarction within the past 3 months
• The subject requires treatment with drugs known to be associated with torsades de pointes or significant QT interval prolongation.
• The subject has a serum potassium level or a serum magnesium level that falls outside the normal range.
• The subject has known brain metastases or a primary brain tumor.
• The subject has intercurrent illness including but not limited to ongoing or active infection.
• The subject is known to be positive for the human immunodeficiency virus (HIV).
• The subject is pregnant or breastfeeding.
• The subject has a previously identified allergy or hypersensitivity to components of the study treatment formulations
• The subject is unable or unwilling to abide by the study protocol or cooperate fully with the investigator or designee

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: 1	Drug: XL647; Tablets supplied at 50-mg strength administered orally daily; Drug: XL147; Gelatin capsules supplied at 25-mg and 100-mg strengths administered orally daily

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Safety, tolerability, and maximum tolerated dose (MTD) of XL647 administered in combination with XL147 orally daily	Assessed at periodic visits

Secondary Outcome Measures

Outcome Measure	Time Frame
Characterize pharmacokinetic parameters of XL647 administered in combination with XL147 daily in subjects with solid tumors	Assessed at periodic visits
Assess pharmacodynamic effects of the XL647 and XL147 combination regimen at the highest safe dose of these agents in subjects with non-small-cell lung cancer or breast cancer	Assessed at periodic visits

Collaborators and Investigators

• Sponsor: Exelixis

Study record dates

Study Major Dates

• Study Start: June 1, 2008
• Primary Completion (Anticipated): December 1, 2009
• Study Completion (Anticipated): December 1, 2009

Study Registration Dates

• First Submitted: June 20, 2008
• First Submitted That Met QC Criteria: June 23, 2008
• First Posted (Estimate): June 24, 2008

Study Record Updates

• Last Update Posted (Estimate): August 20, 2015
• Last Update Submitted That Met QC Criteria: August 19, 2015
• Last Verified: August 1, 2015

More Information

Terms related to this study

• Keywords: NSCLC; Solid tumors
• Additional Relevant MeSH Terms: Respiratory Tract Diseases; Neoplasms; Lung Diseases; Neoplasms by Site; Respiratory Tract Neoplasms; Thoracic Neoplasms; Carcinoma, Bronchogenic; Bronchial Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Molecular Mechanisms of Pharmacological Action; Enzyme Inhibitors; Antineoplastic Agents; Protein Kinase Inhibitors; XL647
• Other Study ID Numbers: XL647-003