- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00731809
Evaluation of PET CT in the Management of Patients With Crohn's Disease.
December 22, 2008 updated by: Rabin Medical Center
18F-FDG PET/CT (2-[fluorine-18] fluoro-2-deoxy-D-glucose, Positron emission tomography- CT) is a noninvasive technique that allows quantifying and precisely localizing 18F-FDG uptake in the entire body.
18F-FDG uptake is caused by increased local metabolic activity.
Such increased uptake has been described not only in neoplastic lesions but also in inflammatory lesions.
In this condition, uptake has been correlated with local stimulation of tumor necrosis factor, and with monocyte priming and activation.
A physiologic variable uptake may be observed in the bowel, especially the cecum, and has limited the use of PET in inflammatory bowel diseases.
The advantage of combined PET and CT devices lead to significant improvements in the interpretation of the bowel areas, and greatly reduces the number of false-positive findings in the gastrointestinal tract.
Study Overview
Study Type
Interventional
Enrollment (Anticipated)
50
Phase
- Phase 4
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
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Petah-tikva, Israel, 49100
- Recruiting
- Rabin Medical Center
-
Contact:
- Bernstine, MD
- Email: hannab2@clalit.org.il
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Principal Investigator:
- Hanna Bernstine, MD
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
Patients suspicious for active disease:
- Patients with suspected but undiagnosed Crohn's disease
- Patients with serological markers of inflammation (elevated ESR, CRP or thrombocytosis) but clinically in remission
- Patients with a stricture which might be fibrous in which case surgery is indicated or inflammatory for which medical management is indicated
- Able to sign a consent form
Exclusion Criteria:
- Pregnancy
- Breastfeeding
- Infectious colitis determined at the initial checkup
- Allergy to iodine contrast
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: Non-Randomized
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Other: 1
PET CT
|
FDG PET CT
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
April 1, 2008
Primary Completion (Anticipated)
April 1, 2010
Study Completion (Anticipated)
October 1, 2010
Study Registration Dates
First Submitted
August 3, 2008
First Submitted That Met QC Criteria
August 7, 2008
First Posted (Estimate)
August 11, 2008
Study Record Updates
Last Update Posted (Estimate)
December 23, 2008
Last Update Submitted That Met QC Criteria
December 22, 2008
Last Verified
February 1, 2008
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 004945
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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