- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00761995
Safety and Efficacy of Brinzolamide Dosed TID With Dorzolamide Dosed TID in Reducing Intraocular Pressure in Patients With Open Angle Glaucoma or Ocular Hypertension
July 17, 2012 updated by: Alcon Research
Safety and Efficacy of Brinzolamide Dosed TID With Dorzolamide Dosed TID in Reducing Intraocular Pressure in Patients With Open Angle Glaucoma or Ocular Hypertension
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
200
Phase
- Phase 4
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Bangalore, India, 560016
- Alcon Laboratories, India
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
16 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Male and females 18 years of age or older, diagnosed with primary open-angle glaucoma or ocular hypertension.
If of child bearing potential
* Must use a reliable means of contraception for the duration of the study or surgically sterilized.
- Must have a negative pregnancy test.
- Must be non-lactating
- IOP measurements ≥ 24 ≤ 36 mm Hg, in at least one eye, at 9.00 a.m and ≥ 21 ≤ 36 mm Hg in at least one eye (the same eye) at 11.00 am measurement
- The IOP criteria to be met at both time points by the same eye
- Visual Acuity of 6/24 or better in study eye (s)
- Gonioscopy angle of ≥ 2 in the study eye (s)
- Patients with a level of understanding and willingness to fully comply with all visits and study procedures scheduled by the study site as evidenced by written informed consent
Exclusion Criteria:
- Patients with one sighted eye or amblyopia
- History of chronic or recurrent uveitis or other inflammatory eye disease (e.g. scleritis).
- History of ocular infections (e.g. conjunctivitis) within past 3 months.
- History of ocular trauma within the past 6 months.
- History of severe or progressive retinal (i.e. retinal degeneration, diabetic retinopathy, retinal detachment or retinal tears) or optic nerve disease.
- History of severe ocular pathology such as severe glaucoma damage determined by optic nerve head (e.g. C/D ratio > 0.8) or visual field evaluation (e.g. split fixation, clinically significant field loss within the central field) or legal blindness in either eye.
- Intraocular surgery within the past 12 months or Laser surgery within the past 3 months as determined by patient history and/or examination.
- Any other form of glaucoma other than primary open angle glaucoma.
- Inability to discontinue contact lens wear during the day
- History of hypersensitivity to oral or topical CAIs, sulfonamide drugs or to any component of these medicines.
- Any abnormality preventing reliable applanation tonometry of either eye.
- Patients who are in the investigator's best judgement at risk of visual field or visual acuity worsening as a consequence of participation of trial.
- Chronic use of any systemic medication that may effect IOP with less than one month stable dosing regimen (i.e. sympathomimetic agents, beta-adrenergic blocking agents, alpha agonists, alpha-adrenergic blocking agents, calcium channel blockers, angiotensin-converting enzyme inhibitors, etc.).
- Current use of any ophthalmic, dermatologic or systemic steroid.
- Patients with clinically significant medical (acute or progressive) condition e.g. cardiovascular, pulmonary, hematologic disease or psychiatric illness, who are unlikely to fully complete all protocol requirements as assessed by the investigator.
- Participation in another clinical trial within past 30 days.
- Pregnant and lactating females
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Azopt
topical eye drop dosed 1 drop 3 times daily
|
topical eye drop dosed 1 drop 3 times daily
|
Active Comparator: Cosopt
topical eye drop
|
topical eye drop dosed 1 drop 2 times daily
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
IOP reduction from baseline at the end of 12 weeks
Time Frame: 12 weeks
|
12 weeks
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
IOP reduction from baseline at the end of 4 and 8 weeks of treatment
Time Frame: 4 and 8 weeks
|
4 and 8 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
February 1, 2009
Primary Completion (Actual)
July 1, 2010
Study Completion (Actual)
July 1, 2010
Study Registration Dates
First Submitted
September 26, 2008
First Submitted That Met QC Criteria
September 29, 2008
First Posted (Estimate)
September 30, 2008
Study Record Updates
Last Update Posted (Estimate)
July 18, 2012
Last Update Submitted That Met QC Criteria
July 17, 2012
Last Verified
January 1, 2012
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- MA-CT-08-003
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Ocular Hypertension
-
Western Galilee Hospital-NahariyaUnknown
-
Laboratoires TheaCompletedOcular Hypertension GlaucomaBulgaria
-
Santen Inc.Completed
-
West Virginia UniversityUniversity of PittsburghRecruitingGlaucoma and Ocular HypertensionUnited States, United Kingdom, Canada
-
University Hospital, GenevaTerminatedGlaucoma and Ocular HypertensionSwitzerland
-
Santen Inc.Completed
-
Maastricht University Medical CenterCompletedCorticosteroid Induced Ocular Hypertension/GlaucomaNetherlands
-
Santen Inc.CompletedA Study Assessing the Safety and Efficacy of DE-117 Ophthalmic Solution in Patients With POAG or OHTGlaucoma and Ocular HypertensionUnited States
-
Bausch & Lomb IncorporatedCompletedGlaucoma | Open Angle or Ocular HypertensionUnited States
-
Nicox Ophthalmics, Inc.CompletedGlaucoma, Open-Angle | Hypertension, OcularUnited States
Clinical Trials on Azopt
-
Alcon ResearchCompleted
-
Alcon ResearchCompleted
-
Bausch & Lomb IncorporatedCompletedGlaucoma | Open Angle or Ocular HypertensionUnited States
-
Sun Pharmaceutical Industries LimitedCompletedPrimary Open Angle Glaucoma | Ocular HypertensionIndia, Russian Federation
-
Alcon ResearchCompletedOcular Hypertension | Glaucoma
-
Bausch & Lomb IncorporatedCompletedGlaucoma | Open Angle or Ocular HypertensionUnited States
-
Padagis LLCCompletedOcular Hypertension | Glaucoma, Open-AngleUnited States
-
University of California, San DiegoCompleted
-
Alcon ResearchCompleted
-
Alcon ResearchCompletedOcular Hypertension | Open-angle GlaucomaUnited States