- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00837850
SmartSet HV and Palacos R RSA Bone Cements in Primary Total Hip Arthroplasty
A Randomised Prospective Trial of SmartSet HV and Palacos R Bone Cements in Primary Total Hip Arthroplasty. A Radiostereometric Analysis of the Charnley Femoral Component.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
The fixation of components in total hip arthroplasty has a significant effect on the long-term survival of the prostheses. Bone cement in total joint replacement acts as an anchoring medium for the prosthesis and provides a barrier to the ingress of wear debris into bone surfaces. However, there are significant differences in cement behaviour among differing types of cement. A clinical study based on the Norwegian Arthroplasty Register demonstrated that there is an increased rate of revision due to aseptic loosening of femoral components implanted with low-viscosity cement compared with that of high-viscosity.
Studies have shown that high early migration for certain designs of femoral prosthesis can be a predictor for clinical loosening. RSA is a technique enabling calculation of the three-dimensional translational and rotational movements of the implant relative to the bone, and therefore provides an ideal technique to detect early micromotion of implants.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- patients in need for total hip arthroplasty
Exclusion Criteria:
- patients with an existing condition such as malignancy, pregnancy, severe osteoporosis and disabling musculoskeletal problems (other than in the hips),
- patients on corticosteroid treatment,
- patients who had already participated in a clinical study with an investigational product in the last 6 months.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: RANDOMIZED
- Interventional Model: PARALLEL
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
ACTIVE_COMPARATOR: 1
|
Bone cement SmartSet® HV
Other Names:
|
ACTIVE_COMPARATOR: 2
|
Bone cement Palacos R
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Distal migration of the charnley femoral stem
Time Frame: 2010
|
2010
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Rotational movements of the charnley femoral stem
Time Frame: 2010
|
2010
|
Collaborators and Investigators
Collaborators
Investigators
- Principal Investigator: Otto S. Husby, PhD, St.Olavs Hospital HF
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Primary Completion (ACTUAL)
Study Completion (ACTUAL)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ESTIMATE)
Study Record Updates
Last Update Posted (ESTIMATE)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 094-02
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Arthritis
-
Northumbria Healthcare NHS Foundation TrustUniversity of YorkRecruitingKnee Arthritis | Hip ArthritisUnited Kingdom
-
MedShape, IncOrthopedic Foot and Ankle Center, Ohio; CurveBeam LLCRecruitingAnkle Arthritis | Arthritis FootUnited States
-
MedShape, IncUniversity of Alabama at BirminghamRecruitingAnkle Arthritis | Foot ArthritisUnited States
-
University of Alabama at BirminghamMedShape, IncRecruiting
-
MedShape, IncThe University of Texas Medical Branch, GalvestonRecruitingAnkle Arthritis | Foot ArthritisUnited States
-
Chang Gung Memorial HospitalNot yet recruitingArthritis Knee | Arthritis HipTaiwan
-
MedShape, IncSaint Alphonsus Medical GroupUnknownAnkle Arthritis | Foot ArthritisUnited States
-
Saint Alphonsus Regional Medical CenterCompletedArthritis Knee | Arthritis of HipUnited States
-
Sunnybrook Health Sciences CentreUniversity Health Network, Toronto; University of TorontoCompleted
-
Smith & Nephew, Inc.TerminatedRheumatoid Arthritis | Traumatic Arthritis | Osteo Arthritis ShouldersUnited States
Clinical Trials on Bone cement 1
-
Michael DunbarCompleted
-
University of AarhusAarhus University Hospital; Zimmer BiometCompleted
-
Medtronic Spinal and BiologicsCompletedPathological Fracture of Vertebra Due to Secondary Osteoporosis (Disorder) | Pathological Fracture of Vertebra Due to Neoplastic Disease (Disorder)China
-
Aarhus University HospitalCompleted
-
Biomet Orthopedics, LLCTerminatedOsteoarthritis, Hip | Traumatic Arthritis of HipUnited States
-
DePuy InternationalCompletedOsteoarthritis | Rheumatoid Arthritis | Avascular Necrosis | Post-traumatic Arthritis | Congenital Hip Dysplasia | Slipped Capital Femoral Epiphysis | Collagen Disorders | Traumatic Femoral Fractures | Nonunion of Femoral FracturesSlovakia
-
University of AarhusAarhus University Hospital; Zimmer BiometWithdrawn
-
Diana Mostafa HabebRecruitingTooth Discoloration | Destructed Teeth Restored by Zirconia Crowns | Zirconia Crowns | Decayed, Missing, and Filled TeethEgypt
-
Pamukkale UniversityNot yet recruiting
-
Zimmer BiometNew Lexington ClinicWithdrawnOsteoarthritis | Rheumatoid Arthritis | Knee Arthritis | Traumatic ArthritisUnited States