A Study of Atrasentan on Reducing Albuminuria in Type 2 Diabetic Nephropathy Treated With Renin-Angiotensin System Inhibitors

A Phase 2a, Prospective, Randomized, Double-blind, Placebo-controlled Multicenter Study to Evaluate the Safety and Efficacy of Atrasentan on Reducing Albuminuria in Type 2 Diabetic Nephropathy Subjects Who Are Currently Being Treated With an Renin-Angiotensin System Inhibitor

The study objective is to investigate the effects of three low doses of atrasentan on urinary albumin/creatinine ratio (UACR) levels in subjects with Type 2 diabetic nephropathy.

Patients with Type 2 diabetes with nephropathy must be receiving a renin-angiotensin system inhibitor, such as an Angiotensin converting enzyme inhibitor (ACEi) or an Angiotensin II Receptor Blocker (ARB) for participation in this study. ACEi and ARB treatment are the standard of care for the management of proteinuria in Chronic Kidney Disease (CKD) patients.

Study Overview

• Status: Completed
• Conditions: Diabetic Nephropathy; Chronic Kidney Disease
• Intervention / Treatment: Drug: 1.75 mg Atrasentan QD; Drug: 0.25 mg Atrasentan QD; Drug: 0.75 mg Atrasentan QD; Drug: Placebo for Atrasentan 0.2 mg/mL solution

• Study Type: Interventional
• Enrollment (Actual): 92
• Phase: Phase 2

Contacts and Locations

Study Locations

• Puerto Rico
  • Las Piedras, Puerto Rico, 00771
    • Site Reference ID/Investigator# 16564
  • Ponce, Puerto Rico, 00717
    • Site Reference ID/Investigator# 19381
  • San Juan, Puerto Rico, 00918
    • Site Reference ID/Investigator# 16563
  • San Juan, Puerto Rico, 00936-5067
    • Site Reference ID/Investigator# 16562
• United States
  • Arizona
    • Tempe, Arizona, United States, 85284
      • Site Reference ID/Investigator# 19386
  • California
    • Azusa, California, United States, 91702
      • Site Reference ID/Investigator# 25043
    • Los Angeles, California, United States, 90022
      • Site Reference ID/Investigator# 23308
    • Los Angeles, California, United States, 90048
      • Site Reference ID/Investigator# 25430
    • San Diego, California, United States, 92123
      • Site Reference ID/Investigator# 20421
    • San Diego, California, United States, 92123
      • Site Reference ID/Investigator# 22442
    • Whittier, California, United States, 90603
      • Site Reference ID/Investigator# 21061
    • Yuba City, California, United States, 95991
      • Site Reference ID/Investigator# 16572
  • Florida
    • Coral Gables, Florida, United States, 33134
      • Site Reference ID/Investigator# 26142
    • Hudson, Florida, United States, 34667
      • Site Reference ID/Investigator# 16567
    • Pembroke Pines, Florida, United States, 33028
      • Site Reference ID/Investigator# 16577
    • Pembroke Pines, Florida, United States, 33028
      • Site Reference ID/Investigator# 25242
  • Maryland
    • Rockville, Maryland, United States, 20852
      • Site Reference ID/Investigator# 16569
  • Nebraska
    • Omaha, Nebraska, United States, 68131
      • Site Reference ID/Investigator# 16574
  • New York
    • Buffalo, New York, United States, 14215
      • Site Reference ID/Investigator# 20221
  • North Carolina
    • Greenville, North Carolina, United States, 27834
      • Site Reference ID/Investigator# 16576
    • Morehead City, North Carolina, United States, 28557
      • Site Reference ID/Investigator# 16573
    • Statesville, North Carolina, United States, 28625
      • Site Reference ID/Investigator# 26143
  • Pennsylvania
    • Bethlehem, Pennsylvania, United States, 18017
      • Site Reference ID/Investigator# 19383
  • South Carolina
    • Orangeburg, South Carolina, United States, 29115
      • Site Reference ID/Investigator# 26365
  • Texas
    • San Antonio, Texas, United States, 78229-4801
      • Site Reference ID/Investigator# 16571
    • San Antonio, Texas, United States, 78229
      • Site Reference ID/Investigator# 16566
    • San Antonio, Texas, United States, 78229
      • Site Reference ID/Investigator# 19384
  • Virginia
    • Fairfax, Virginia, United States, 22030
      • Site Reference ID/Investigator# 24542

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• 1.Subject is >= 18 years old.
• 2.Subject has voluntarily signed and dated an informed consent form, approved by an Institutional Review Board (IRB)/Independent Ethics Committee (IEC), after the nature of the study has been explained and the subject has had the opportunity to ask questions. The informed consent must be signed before any study-specific procedures are performed.
• 3.Subject has Type 2 diabetes and has been treated with at least one anti-hyperglycemic medication within the 12 months prior to the Screening Phase.
• 4.Subject has been receiving a stable dose (i.e., same type and regimen) of angiotensin-converting enzyme inhibitors (ACEi) and/or angiotensin receptor blocking agents (ARB) for at least 2 months prior to the Screening Phase.
• 5.If female, subject must be not of childbearing potential, defined as postmenopausal for at least 1 year or surgically sterile (bilateral tubal ligation, bilateral oophorectomy or hysterectomy). The reason for non-childbearing potential must be specified in the subject's eCRF.
• 6.If male, subject must be surgically sterile or if sexually active and of childbearing potential, the site must document the lack of desire for future procreation and subject must agree to use a condom and a second reliable barrier of contraception from the Screening Visit through two months following completion of their participation in the study.

• 7.For entry into the Treatment Phase the subject must satisfy the following criteria based on Screening laboratory values:

  • a.Estimated GFR > 20 mL/min/1.73 m2 by simplified MDRD formula
  • b.UACR between 100 and 3000 mg/g as determined at the initial Screening visit or by the mean of the 2 morning void urine specimens obtained prior to the second Screening visit.
  • c.Serum albumin > 3.0 g/dL.
  • d.HbA1c <= 10%.
  • e.Pro-BNP <= 500pg/mL.
  • f.Negative urine pregnancy test for female subjects.

Exclusion Criteria:

• 1.Subject has a history of significant peripheral edema (2 + or greater), or facial edema unrelated to trauma, or a history of myxedema in the 6 months prior to Screening.
• 2.Subject receiving loop diuretics > 30 mg BID of furosemide or > 0.5 mg BID of bumetanide or > 25 mg BID of ethacrynic acid.
• 3.Subject has a history of pulmonary edema.
• 4.Subject has a history of pulmonary hypertension, chronic obstructive pulmonary disease, emphysema, pulmonary fibrous disease, asthma or other lung disease that requires oxygen.
• 5.Subject has a documented history of heart failure, defined as New York Heart Association (NYHA) Class II, III or IV heart failure.
• 6.Subject has a body mass index (BMI) > 40.
• 7.Subject has elevated liver enzymes (ALT and/or AST) > 1.5 x the upper limit of normal (ULN).
• 8.Subject has a hemoglobin < 9.5 g/dL.
• 9.Subject has a history of an allergic reaction or significant sensitivity to atrasentan or its excipients.
• 10.Subject has a history of a chronic gastrointestinal disease, which in the Investigator's opinion may cause significant GI malabsorption.
• 11.Subject has a history of secondary hypertension (i.e., renal artery stenosis, primary aldosteronism or pheochromocytoma).
• 12.Subject has poorly controlled hypertension (systolic blood pressure ≥ 160 mmHg and or diastolic blood pressure ≥ 90 mmHg) or hypotension (systolic blood pressure <= 90 mmHg).
• 13.Subject has significant comorbidities (e.g., advanced malignancy, advanced liver disease) with a life expectancy less than 1 year.
• 14.Subject is expected to receive an increased dose of current RAAS inhibitor (ACEi, ARB, renin or aldosterone inhibitor) during the course of the study. Conversions from one product to another (e.g., ACEi to ARB) must be at equivalent doses.

• 15.Subject has clinically significant coronary artery disease (CAD) within 3 months prior to the Screening Period, defined as one of the following:

  • Hospitalization for MI or unstable angina; or
  • New onset angina with positive functional study or coronary angiogram revealing stenosis; or
  • Coronary revascularization procedure.
• 16.Subject has a history of viral or bacterial infection within 4 weeks of Screening or HIV infection.
• 17.Subject has scheduled or planned surgery with general anesthesia within 12 weeks of Screening Visit.
• 18.Subject has a history of drug or alcohol abuse within 6 months prior to the Screening Visit.
• 19.Subject has evidence of poor compliance with diet or medication that may interfere, in the Investigator's opinion, with adherence to the protocol.
• 20.Subject has received any investigational drug within 30 days prior to study drug administration.
• 21.For any reason, subject is considered by the Investigator to be an unsuitable candidate to receive atrasentan oral solution or is put at risk by study procedures

Study Plan

How is the study designed?

Design Details

• Primary Purpose: TREATMENT
• Allocation: RANDOMIZED
• Interventional Model: PARALLEL
• Masking: QUADRUPLE

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
ACTIVE_COMPARATOR: A	Drug: 1.75 mg Atrasentan QD; 10 mL oral solution, daily, 8 weeks
ACTIVE_COMPARATOR: B	Drug: 0.25 mg Atrasentan QD; 10 mL oral solution, daily, 8 weeks
ACTIVE_COMPARATOR: C	Drug: 0.75 mg Atrasentan QD; 10 mL oral solution, daily, 8 weeks
PLACEBO_COMPARATOR: D	Drug: Placebo for Atrasentan 0.2 mg/mL solution; 10 mL oral solution, daily, 8 weeks

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Mean change from baseline to each post-baseline observation on UACR over the course of treatment period versus standard of care	Week 8 visit or final assessment

Secondary Outcome Measures

Outcome Measure	Time Frame
Proportion of subjects achieving at least a 25% reduction in final UACR levels from baseline	Week 8 visit or final assessment
Proportion of subjects achieving at least a 40% reduction in final UACR levels from baseline	Week 8 visit or final assessment
Change from baseline to the final value in UACR, estimated glomerular filtration rate (eGFR), Neutrophil Gelatinase-Associated Lipocalin (NGAL)	Week 8 visit or final assessment
Change from baseline to each weekly measurement in NGAL	Week 8 visit or final assessment

Collaborators and Investigators

• Sponsor: AbbVie (prior sponsor, Abbott)
• Investigators: Study Director: Dennis Andress, AbbVie

Publications and helpful links

General Publications

• Perez-Gomez MV, Sanchez-Nino MD, Sanz AB, Martin-Cleary C, Ruiz-Ortega M, Egido J, Navarro-Gonzalez JF, Ortiz A, Fernandez-Fernandez B. Horizon 2020 in Diabetic Kidney Disease: The Clinical Trial Pipeline for Add-On Therapies on Top of Renin Angiotensin System Blockade. J Clin Med. 2015 Jun 18;4(6):1325-47. doi: 10.3390/jcm4061325.

Study record dates

Study Major Dates

• Study Start: June 1, 2009
• Primary Completion (ACTUAL): April 1, 2010
• Study Completion (ACTUAL): May 1, 2010

Study Registration Dates

• First Submitted: June 11, 2009
• First Submitted That Met QC Criteria: June 12, 2009
• First Posted (ESTIMATE): June 15, 2009

Study Record Updates

• Last Update Posted (ACTUAL): June 6, 2018
• Last Update Submitted That Met QC Criteria: June 1, 2018
• Last Verified: January 1, 2013

More Information

Terms related to this study

• Keywords: Proteinuria; Endothelin antagonist; CKD Stages 3&4
• Additional Relevant MeSH Terms: Urologic Diseases; Urological Manifestations; Endocrine System Diseases; Diabetes Complications; Diabetes Mellitus; Renal Insufficiency; Urination Disorders; Proteinuria; Kidney Diseases; Renal Insufficiency, Chronic; Diabetic Nephropathies; Albuminuria; Molecular Mechanisms of Pharmacological Action; Antineoplastic Agents; Endothelin Receptor Antagonists; Endothelin A Receptor Antagonists; Atrasentan
• Other Study ID Numbers: M10-815