Effects of Cardiac Rehabilitation for Individuals With Transient Ischemic Attack

Effects of Cardiac Rehabilitation for Individuals With Transient Ischemic Attack

Sponsors

Lead sponsor: Toronto Rehabilitation Institute

Collaborator: Heart and Stroke Foundation of Canada

Source Toronto Rehabilitation Institute
Brief Summary

It is hypothesized that the addition of formal cardiac rehabilitation to standard care will result in long-term improvements in cardiovascular fitness and functional capacity in individuals who have suffered a transient ischemic attack (TIA) or minor stroke.

Furthermore, it is proposed that the addition of cardiac rehabilitation will influence depressive symptoms and cognition.

Detailed Description

A transient ischemic attack (TIA) is defined as an episode of neurological dysfunction caused by focal brain ischemia lasting less than 24 hours. Once an individual has suffered a TIA, preventative measures can be taken to target modifiable risk factors, one of which is physical inactivity. The current proposal focuses on the use of an established model of care (cardiac rehabilitation (CR)) and applies it to those who have suffered a TIA in order to maximize physical activity and minimize risk of future cardiovascular events. This will be a one-group pre/post design study with a 3 month non-intervention period. Participants will undergo measures at baseline and 3 months (non intervention period) then after 6 months of cardiac rehabilitation (cardiovascular fitness, 6 minute walk test, cognition, and depressive symptoms).

Overall Status Completed
Start Date March 2010
Completion Date November 2014
Primary Completion Date November 2014
Study Type Observational
Primary Outcome
Measure Time Frame
Functional Walk Test Baseline, 3 months, 6 months (Six Minute Walk Distance)
Cardiovascular Fitness (VO2peak) Baseline (after the 3 month non-intervention period) and after 6 months of participation.
Secondary Outcome
Measure Time Frame
Center for Epidemiologic Studies Depression Scale (CES-D). Baseline and 3 months (non-intervention period), after 6 months of cardiac rehabilitation participation
Cognition Baseline and 3 months (non-intervention period), after 6 months of cardiac rehabilitation participation
Enrollment 20
Condition
Intervention

Intervention type: Behavioral

Intervention name: Cardiac Rehabilitation

Description: Individualized cardiac rehabilitation for 6 months, including health education sessions, as well as supervised exercise classes which include aerobic and resistance training.

Arm group label: Exercise

Eligibility

Sampling method: Probability Sample

Criteria:

Inclusion Criteria:

- Diagnosed with TIA

- Three months post-TIA

- Ability to understand the process and instructions for exercise training and provide informed consent

Exclusion Criteria:

- Resting Blood Pressure greater than 160/100 despite medication

- Other cardiovascular morbidity which would limit exercise tolerance (heart failure, abnormal BP responses or STsegment depression > 2 mm, symptomatic aortic stenosis, complex arrhythmias)

- Current and extensive exercise participation

- Hypertrophic Cardiomyopathy

- Unstable Angina

- Orthostatic BP decrease of > 20 mm Hg with symptoms

- Other musculoskeletal impairments which would limit the participants ability to walk sufficient durations

- Pain or other co-morbidities (e.g., unclipped aneurysms, uncontrolled seizures etc.) which would preclude participation

- Cognitive or behavioural issues that would limit participation in exercise testing and training

Gender: All

Minimum age: 18 Years

Maximum age: 100 Years

Healthy volunteers: No

Overall Official
Location
facility
Toronto Rehabilitation Institute - Rumsey Center
Location Countries

Canada

Verification Date

April 2019

Responsible Party

Responsible party type: Principal Investigator

Investigator affiliation: Toronto Rehabilitation Institute

Investigator full name: Dina Brooks

Investigator title: Professor

Keywords
Has Expanded Access No
Condition Browse
Arm Group

Arm group label: Exercise

Description: Following a 3 month non intervention period, participants will participate in Cardiac Rehabilitation, carrying out an exercise program which will last 6 months and combine both resistance and aerobic training.

Study Design Info

Observational model: Cohort

Time perspective: Prospective

Source: ClinicalTrials.gov