- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00934193
Does Peri-Operative Gabapentin Reduce Chronic Post-Thoracotomy Pain?
December 15, 2015 updated by: University of Kansas Medical Center
The primary objective of this study is to determine if gabapentin can decrease or prevent chronic post-thoracotomy pain.
Study Overview
Status
Withdrawn
Conditions
Intervention / Treatment
Detailed Description
This study is a prospective double blind randomized controlled trial evaluating the peri-operative use of gabapentin in the prevention or modulation of post-thoracotomy hyperalgesia.
Treatment will consist of a 600 mg dose of gabapentin or placebo given preoperatively the night before surgery, based on a computer generated randomized assignment.
The treatment group will continue to be medicated with gabapentin 300 mg twice daily for one month following surgery.
Those not included in the treatment arm of the study will continue to take a placebo for the same duration.
Follow-up will consist of a postoperative visit at approximately 48 hours and a one month clinical visit.
Study Type
Interventional
Phase
- Phase 3
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- 18 years or older
- Undergoing non-cardiac thoracic surgeries
- Patients determined to have impaired decisional capacity with respect to the provision of informed consent or prisoners will not be included in the study.
Exclusion Criteria:
- Current gabapentin use or current treatment for neuropathic pain.
- Pregnant or considering becoming pregnant.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Placebo Comparator: Placebo
|
Treatment will consist of a 600 mg dose of gabapentin or placebo given preoperatively the night before surgery, based on a computer generated randomized assignment.
The treatment group will continue to be medicated with gabapentin 300 mg twice daily for one month following surgery.
Those not included in the treatment arm of the study will continue to take a placebo for the same duration.
Follow-up will consist of a postoperative visit at approximately 48 hours and a one month clinical visit.
|
Active Comparator: Gabapentin
|
Treatment will consist of a 600 mg dose of gabapentin or placebo given preoperatively the night before surgery, based on a computer generated randomized assignment.
The treatment group will continue to be medicated with gabapentin 300 mg twice daily for one month following surgery.
Those not included in the treatment arm of the study will continue to take a placebo for the same duration.
Follow-up will consist of a postoperative visit at approximately 48 hours and a one month clinical visit.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
The primary objective of this study is to determine if gabapentin can decrease or prevent chronic post-thoracotomy pain.
Time Frame: 6 Months
|
6 Months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Collaborators
Investigators
- Principal Investigator: Sinisa Malinovic, MD, Ascension Via Christi Hospitals Wichita, Inc.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
July 1, 2009
Primary Completion (Actual)
June 1, 2011
Study Completion (Actual)
June 1, 2011
Study Registration Dates
First Submitted
July 6, 2009
First Submitted That Met QC Criteria
July 7, 2009
First Posted (Estimate)
July 8, 2009
Study Record Updates
Last Update Posted (Estimate)
December 16, 2015
Last Update Submitted That Met QC Criteria
December 15, 2015
Last Verified
December 1, 2015
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Physiological Effects of Drugs
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Central Nervous System Depressants
- Peripheral Nervous System Agents
- Analgesics
- Sensory System Agents
- Excitatory Amino Acid Antagonists
- Excitatory Amino Acid Agents
- Tranquilizing Agents
- Psychotropic Drugs
- Anti-Anxiety Agents
- Anticonvulsants
- Antimanic Agents
- Gabapentin
Other Study ID Numbers
- 220081131
- WMREF 80104-257 (Other Identifier: WMREF IRB)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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