A Reduced 11 Beta Hydroxysteroid Dehydrogenase 2 (11 Beta HSD2) Activity, a Novel Mechanism of Salt Sensitivity and Hypertension After Renal Allograft Donation?

A Reduced 11-b-HSD Activity, a Novel Mechanism of Salt Sensitivity and Hypertension After Renal Allograft Donation?

Sponsors

Lead sponsor: University Hospital Inselspital, Berne

Source University Hospital Inselspital, Berne
Brief Summary

Consecutive living-kidney donor candidates (n=100) will be recruited after being accepted for donation according to official guidelines. An assessment of salt sensitivity, 11 beta HSD activity, 24 hour blood pressure, urine collection and physical exam will be performed prior nephrectomy and 14, 52, 156, 208 days post-nephrectomy.

Detailed Description

Consecutive living-kidney donor candidates (n=100) will be recruited after being accepted for donation. The assessment of salt sensitivity, 11 beta HSD activity, 24 hour blood pressure, urine collection and physical exam will be performed prior nephrectomy and 14, 52, 156, 208 days post-nephrectomy.

Overall Status Completed
Start Date June 2009
Completion Date July 2010
Primary Completion Date July 2010
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
Salt sensitivity, arterial hypertension day 0, 14, 52, 156, 208, yearly
Enrollment 100
Condition
Intervention

Intervention type: Dietary Supplement

Intervention name: Low and high salt diets

Description: High salt diet: 150mmol/d Low salt diet: 30mmol/d

Arm group label: 1

Other name: NaCl

Eligibility

Criteria:

Inclusion Criteria:

- acceptance for living kidney donation

Exclusion Criteria:

- withdrawal of consent

Gender: All

Minimum age: 20 Years

Maximum age: 70 Years

Healthy volunteers: No

Overall Official
Last Name Role Affiliation
Felix J Frey, Prof Principal Investigator University of Berne
Location
facility Department of nephrology and hypertension, Universitiy of Bern
Location Countries

Switzerland

Verification Date

May 2011

Responsible Party

Name title: Felix Frey, Department of Nephrology and Hypertension

Organization: University of Berne, Switzerland

Has Expanded Access No
Condition Browse
Number Of Arms 1
Arm Group

Arm group label: 1

Arm group type: Other

Study Design Info

Allocation: N/A

Intervention model: Single Group Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Source: ClinicalTrials.gov