High-Field MRI Characterization of Wrist and Hand Cartilage Abnormalities in Inflammatory and Chronic Rheumatisms

August 27, 2014 updated by: Assistance Publique Hopitaux De Marseille
The present project aims at evaluating the diagnostic potential of high-field MRI (3 Teslas) for joint disease. At this field, given that isotropic image resolution of 400 microns can be obtained, one could expect an early detection of joint abnormalities. The additional aim of this project will be to develop a quantitative analyse of the corresponding high-resolution images.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

34

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Marseille, France
        • Assistance Publique Hopitaux de Marseille

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • gp Suspects or affected by rheumatoid polyarthritis

    1. Morning articular Stiffness of at least 15 minutes.
    2. Arthalgias or Arthritises of at least three joints(articulations), among which those of the hand.
    3. Possible rheumatoid Presence of a factor(mailman) and\or Antibody anti peptides positive citrullinés.
    4. Typical possible radiological Hurts on the standard clichés(pictures) of the reached(affected) joints(articulations).

  • gp Affected by stiffening spondylitis with axial and peripheral infringement :

    . Lumbago and steepness lumbar vertebra inflammatory. 2. Arthralgias and\or peripheral arthritises 3. Possible presence of an allèle HLA 4. Possible presence of a sacro-illite 5. Absence of the other rheumatic markers

  • gp Affected by connectivity with anti-nuclear antibody positive and / or specific antibodies, suffering of polyarthralgias with or without arthritis
  • gp Healthy control
  • gp Presenting a degenerative osteoarthritis of the wrist traumatic comment, noticed radiologically, which will serve as not inflammatory control.

Exclusion Criteria:

  • Claustrophobia,
  • metallic foreign bodies,
  • pacemakers The pregnant women,
  • parturients or who breast-feed are excluded from the study

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Diagnostic
  • Allocation: Non-Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Other: Suspects or affected by rheumatoid polyarthritis
Other: high-field MRI (3 Teslas)
high-field MRI (3 Teslas)
Other: stiffening spondylitis with axial and peripheral infringement
Other: high-field MRI (3 Teslas)
high-field MRI (3 Teslas)
Other: polyarthralgies with or without arthritis
Affected by connectivity with anti-nuclear antibody positive and / or specific antibodies, suffering of polyarthralgias with or without arthritis
Other: high-field MRI (3 Teslas)
high-field MRI (3 Teslas)
Other: Healthy control
Other: high-field MRI (3 Teslas)
high-field MRI (3 Teslas)
Other: not inflammatory control
Presenting a degenerative osteoarthritis of the wrist traumatic comment, noticed radiologically, which will serve as not inflammatory control.
Other: high-field MRI (3 Teslas)
high-field MRI (3 Teslas)

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
can be obtained, one could expect an early detection of joint abnormalities
Time Frame: 24 months
24 months

Secondary Outcome Measures

Outcome Measure
Time Frame
will be to develop a quantitative analyse of the corresponding high-resolution images.
Time Frame: 24 months
24 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Assistance Publique Hopitaux De Marseille

Investigators

  • Principal Investigator: sandrine guis, PU PH, Assistance Publique Hopitaux de Marseille

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

December 1, 2009

Primary Completion (Actual)

February 1, 2013

Study Completion (Actual)

February 1, 2013

Study Registration Dates

First Submitted

January 27, 2010

First Submitted That Met QC Criteria

January 27, 2010

First Posted (Estimate)

January 28, 2010

Study Record Updates

Last Update Posted (Estimate)

August 28, 2014

Last Update Submitted That Met QC Criteria

August 27, 2014

Last Verified

August 1, 2014

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2009-A01040-57
  • 2009 28 (Other Identifier: 2009 28)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Inflammation

Clinical Trials on high-field MRI (3 Teslas)

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Sri Lanka

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe