- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01085734
Single Site, Masked, Randomized, Controlled Study to Assess Efficacy of Osurdex as Adjunct to Avastin Compared With Avastin Alone in the Treatment of Patients With Macular Edema Due to Central or Branch Retinal Vein Occlusion
March 13, 2014 updated by: Raj K. Maturi, MD, Maturi, Raj K., M.D., P.C.
A 6-Month, Single Site, Masked, Randomized,Controlled Study to Assess Efficacy of Osurdex as Adjunct to Avastin Compared With Avastin Alone in the Treatment of Patients With Macular Edema Due to Central or Branch Retinal Vein Occlusion
Comparative study to see if treating with Osurdex in addition to Avastin in patients with retinal vein occlusions helps increased visual acuity outcomes
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
30
Phase
- Phase 4
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Indiana
-
Indianapolis, Indiana, United States, 46290
- Raj K. Maturi, MD
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- male or female age 18 years or older
- Branch retinal vein occlusion or central retinal vein occlusion of less than one year duration
- Best correct visual acuity of greater than 24 and less than 80
- Presence of macular edema defined as OCT central subfield thickness of >250
Exclusion Criteria:
- intravitreal anti-VEGF treatment in study eye within six weeks of baseline
- intravitreal steroid treatment in the study eye within eight weeks of baseline visit
- PRP in the study eye within 4 month of baseline visit
- Active iris neovascularization in study eye
- Uncontrolled systemic disease
- Known history of IOP elevation in response to corticosteroid treatment that is not controlled on 2 glaucoma medications
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Group 1
Group 1 receives Avastin at baseline followed by sham Osurdex at week 1.
Additional Avastin based on macular edema
|
1.25mg intravitreally
|
Active Comparator: Group 2
Group 2 receives Avastin at baseline followed by Osurdex at week 1.
Retreatment with Avastin based on macular edema
|
1.25mg intravitreally
0.7mg intravitreally
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change From Baseline Visual Acuity at 6 Months
Time Frame: 6 months
|
Visual Acuity was measured with ETDRS visual acuity test.
Unit of measure is based on the ETDRS letter score scale, 0-97, where 0 = worst and 97 = best.
|
6 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Number of Injections Needed
Time Frame: baseline to 6 months
|
number of Avastin and Ozurdex injections needed
|
baseline to 6 months
|
Change in Macular Thickness and Macular Volume
Time Frame: 6 months
|
OCT central subfield thickness measured in microns
|
6 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
March 1, 2010
Primary Completion (Actual)
October 1, 2011
Study Completion (Actual)
October 1, 2011
Study Registration Dates
First Submitted
March 10, 2010
First Submitted That Met QC Criteria
March 11, 2010
First Posted (Estimate)
March 12, 2010
Study Record Updates
Last Update Posted (Estimate)
April 21, 2014
Last Update Submitted That Met QC Criteria
March 13, 2014
Last Verified
March 1, 2014
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Cardiovascular Diseases
- Vascular Diseases
- Eye Diseases
- Retinal Degeneration
- Retinal Diseases
- Embolism and Thrombosis
- Venous Thrombosis
- Thrombosis
- Macular Degeneration
- Macular Edema
- Retinal Vein Occlusion
- Physiological Effects of Drugs
- Antineoplastic Agents
- Antineoplastic Agents, Immunological
- Angiogenesis Inhibitors
- Angiogenesis Modulating Agents
- Growth Substances
- Growth Inhibitors
- Bevacizumab
Other Study ID Numbers
- OA001
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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