- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01123551
Efficacy Study of Nebulized Morphine and Intravenous Morphine in Post Traumatic Pain
July 22, 2014 updated by: Nouira, University of Monastir
Nebulized Morphine Versus Intravenous Morphine in the Management of Post Traumatic Pain in Emergency Department (ED)
In the emergency department, 60% of patients have an acute pain. Appropriate management of acute pain is a public health priority according to who recommendations. Nebulized morphine has been extensively studied in children but less well in adults.
It offers a non-invasive route for systemic drug delivery, more rapid and less invasive than intravenous (IV) method.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
200
Phase
- Phase 3
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
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Monastir, Tunisia, 5000
- Fattouma Bourguiba University Hospital
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
8 years to 50 years (Child, Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Post-traumatic pain with visual analog pain scale( VAPS) ≥ 50%
- Age between 8 and 50 years.
Exclusion Criteria:
- Glasgow coma scale (GCS)< 14,
- Severe injury ,
- Hypotension : blood systolic pressure < 90 mmhg,
- Bradypnea < 12 cpm or SaO2< 90%,
- Chronic pain treatment,
- Aspirin or paracetamol treatment within 6 hours of emergency presentation,
- Nasal trauma, rhinitis, nasal obstruction,
- Incapacity to cooperate,
- Opiate allergy,
- Drug addiction,
- Pregnancy, breast feeding,
- Severe renal and liver failure and chronic obstructive pulmonary disease(COPD)
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Nebulized Morphine
After randomization, patients will receive 10 mg of morphine (1ml) diluted in 4 ml normal saline and nebulized with 6 l/mn during 10 min.
Nebulization will be repeated systematically 3 times every twenty minutes unless the patient pain was resolved (VAPS 30%).
In addition, patients receive a bolus of IV placebo(5 ml normal saline .
IV placebo (2 ml) will be repeated every 10 minutes if the objective of analgesia was not reached .
|
After randomization, patients will receive 10 mg of morphine (1ml) diluted in 4 ml normal saline and nebulized with 6 l/mn during 10 min.
Nebulization will be repeated systematically 3 times every twenty minutes unless the patient pain was resolved (VAPS 30%).
In addition, patients receive a bolus of IV placebo(5 ml normal saline .
IV placebo (2 ml) will be repeated every 10 minutes if the objective of analgesia was not reached .
After randomization, patients will receive a bolus of 5 mg of IV morphine (5 ml.
Then, 2mg of IV morphine (2ml) will be added every 10 minutes if the objective of analgesia was not reached (VAPS >30%).
In addition, normal saline (5ml)is nebulized with 6 l/mn during 10 min and will be repeated systematically every 20 minutes unless the patient's pain was not resolved (VAPS >30%).
|
Active Comparator: Intravenous morphine
After randomization, patients will receive a bolus of 5 mg of IV morphine (5 ml.
Then, 2mg of IV morphine (2ml) will be added every 10 minutes if the objective of analgesia was not reached (VAPS >30%).
In addition, normal saline (5ml)is nebulized with 6 l/mn during 10 min and will be repeated systematically every 20 minutes unless the patient's pain was not resolved (VAPS >30%).
|
After randomization, patients will receive a bolus of 5 mg of IV morphine (5 ml.
Then, 2mg of IV morphine (2ml) will be added every 10 minutes if the objective of analgesia was not reached (VAPS >30%).
In addition, normal saline (5ml)is nebulized with 6 l/mn during 10 min and will be repeated systematically every 20 minutes unless the patient's pain was not resolved (VAPS >30%).
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
1. Resolution rate
Time Frame: one hour
|
resolution is defined as VAPS <30%.
|
one hour
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
rate of side effects
Time Frame: one hour
|
Dyspnea, cutaneous rush, vomiting, nausea, pruritus and dizziness.
|
one hour
|
Resolution time
Time Frame: one hour
|
Resolution time is defined as the time between the starting of the protocol and pain decrease to a Visual Analog Scale less than 30%
|
one hour
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
June 1, 2010
Primary Completion (Actual)
July 1, 2014
Study Completion (Actual)
July 1, 2014
Study Registration Dates
First Submitted
May 11, 2010
First Submitted That Met QC Criteria
May 13, 2010
First Posted (Estimate)
May 14, 2010
Study Record Updates
Last Update Posted (Estimate)
July 23, 2014
Last Update Submitted That Met QC Criteria
July 22, 2014
Last Verified
July 1, 2014
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- Morphine
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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