Development of an Instrumented System to Measure Mobility in Parkinson's Disease

Developing technology to increase efficiency and decrease cost of clinical trials. The longterm objective of this project is to use new technologies to sensitively measure, automatically analyze and efficiently manage clinical trial data for Parkinson's disease (PD) and other neurological disorders. This project will focus on developing objective measures of balance and gait because mobility disability and falls are so critical for quality of life in PD. Clinical movement disorders experts will team up with a local start-up business to develop, produce, and test a novel clinical balance and gait assessment tool, the instrumented Timed Up and Go Test (iTUG) for patients with Parkinson's disease. Balance and gait will be measured with wireless sensors worn on the wrists, ankles and trunk while patients stand up from a chair, walk, turn and return to sit on the chair. Accelerations and angular velocities from the sensors will be automatically transmitted, stored, analyzed, and displayed as Mobility Scores on a remote, centralized computer, along with other patient information important for clinical trials. Specifically, this proposal will 1) create a commercially-available, clinical trial system that includes completely wireless sensor technology, a custom-made, user-friendly, computer interface and efficient data management server; 2) develop a mobility score from many potential balance and gait measures and 3) compare the sensitivity of the iTUG compared to traditional clinical tests of balance to changes in PD due to antiparkinson medication. By providing a more sensitive, accurate, and comprehensive method to quickly test and analyze balance and gait, clinical trials to improve mobility in patients with Parkinson's disease and other neurological disorders will be significantly more effective and efficient. This will permit clinical trials in Parkinson's disease to be completed with fewer subjects, shorter duration, and less cost.The current project will accelerate the development of new therapies for Parkinson's disease.

Study Overview

• Status: Completed
• Conditions: Parkinson's Disease

Detailed Description

The specific aims of the study:

Aim I. To create a novel, commercially-available system for mobility assessment in clinical trials for Parkinson's disease. We have already developed a laboratory prototype system for the iTUG test, but the computer interface, sensors, and data management system are too cumbersome for use in clinical trials. In this proposal, we will create a robust, user-friendly clinical system for the iTUG test using wireless inertial sensors and a new user interface developed by a Portland start-up company, Automated Parkinson's Disease Monitoring (APDM), headed by a co-investigator. This mobility measuring system will be integrated with a new centralized data management server also developed by APDM, Inc. to support automatic data analysis and data organization for multi-site clinical trials. The feasibility of the new, clinical system will then be vetted by using it in a busy Movement Disorders Clinic.

Aim II. To develop an objective, composite iTUG mobility score. We recently demonstrated that iTUG metrics are more sensitive in distinguishing mobility performance between people just diagnosed with PD from age-matched controls than traditional clinical tests. In this proposal, we will develop a composite mobility score from the iTUG gait and postural parameters most responsive to severity of PD and to the change from the levodopa ON and OFF states. The composite score will be calculated using statistical models that optimize differences in performance between 75 subjects with PD in the ON and OFF levodopa state.

Aim III. To prospectively determine the reliability, validity and responsiveness of the iTUG mobility score. We will perform a prospective study with 60 patients with PD that compares standard clinical measures of postural instability and gait difficulty mobility (PIGD items from the Unified Parkinson's Disease Rating Scale (UPDRS) and TUG stop-watch scores) with our new iTUG mobility score in the OFF and ON levodopa states. We hypothesize that the iTUG will have good test-retest reliability, be significantly correlated with standard clinical measures and fall history and be more responsive to dopaminergic state than current mobility tests used in clinical trials. This project will develop, produce, and test a novel clinical balance and gait assessment tool, the instrumented Timed Up and Go test (iTUG) using our new, wearable, inertial sensors and our new clinical trial data management server that automatically transmits, stores, and analyzes data collected with the iTUG. By automatically providing a more sensitive, accurate, and comprehensive method to test balance and gait, clinical trials to improve mobility in patients with Parkinson's disease and other neurological disorders will be significantly more effective and efficient.

• Study Type: Observational
• Enrollment (Actual): 160

Contacts and Locations

Study Locations

• United States
  • Oregon
    • Portland, Oregon, United States, 97239
      • Oregon Clinical Translational Research Institute

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 50 years to 80 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Movement Disorders Clinic at OHSU in Portland Oregon.

Description

Inclusion Criteria:

• Diagnosis of idiopathic Parkinson's Disease
• Ages 50-80
• Currently taking some form of Carbidopa/Levodopa

Exclusion Criteria:

• Significant orthopedic injuries or surgeries
• Deep-Brain-Stimulation surgery
• Any other neurological conditions

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Parkinson's disease; Individuals participating in the study have been diagnosed with idiopathic Parkinson's disease.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
iMOBILITY: the instrumented system for measuring mobility.	Instrumented system for measuring mobility. Which measures over a 100 different variables of movement, for example: Cadence, Turning Duration, Turning Velocity etc...	2 years

Collaborators and Investigators

• Sponsor: Oregon Health and Science University
• Collaborators: National Institute of Neurological Disorders and Stroke (NINDS); National Multiple Sclerosis Society
• Investigators: Principal Investigator: Fay Horak, Phd, Oregon Health and Science University

Study record dates

Study Major Dates

• Study Start: October 1, 2009
• Primary Completion (Actual): October 1, 2014
• Study Completion (Actual): October 1, 2014

Study Registration Dates

• First Submitted: August 2, 2010
• First Submitted That Met QC Criteria: August 3, 2010
• First Posted (Estimate): August 4, 2010

Study Record Updates

• Last Update Posted (Estimate): November 2, 2014
• Last Update Submitted That Met QC Criteria: October 31, 2014
• Last Verified: October 1, 2014

More Information

Terms related to this study

• Keywords: mobility; balance; ON/OFF Levodopa
• Additional Relevant MeSH Terms: Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Parkinsonian Disorders; Basal Ganglia Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Parkinson Disease
• Other Study ID Numbers: 5029