Mentalization - Based Treatment: Adolescents With Co-morbid Depression and Personality Disorder (MBT)

October 2, 2014 updated by: Trudie Rossouw, North East London Foundation Trust

Mentalization - Based Treatment for Young People Presenting With Co-morbid Depression and Symptoms of Emerging Personality Disorder: Prospective Controlled Trial.

Mentalisation based treatment (MBT) for young people with co-morbid depression and emerging personality disorder will be more effective in a day/inpatient setting than treatment as usual.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Detailed Description

Systematic literature review on outcomes with young people with depression and emerging personality disorder showed clear evidence that this group of young people are severely hampered and adult outcomes are strongly linked to both adult PD as well as adult psychiatric disturbance and lower levels of adult functioning. (Crawford et al, 2008; Kasen et al, 1999; Kasen et al, 2007; Lewinsohn et al, 1999) This argues very clearly for the need to diagnose young people presenting with co-morbid depression and emerging personality disorder in order to intervene and help these young people's struggles as it will prevent poor prognostic adult outcomes. There were no treatment programs that specifically focussed on the treatment of this co-morbid group in the literature. Several studies focussed on the treatment of depression alone and only one RCT focussed on the treatment of adolescent personality disorder (Chanen et al, 2007). In adult studies mentalization-based treatment programs were found to be effective ( as well as cost effective) in a day hospital setting for adults with personality disorder and depression (Bateman, et al, 2007) This study aims to conduct a control trial to test whether MBT will be more effective than TAU in this group. All cases will be tested on admission, at discharge and followed up at 2 years post discharge.

Study Type

Interventional

Enrollment (Anticipated)

75

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • United Kingdom
    • Essex
      • Ilford, Essex, United Kingdom, IG3 8XQ
        • Recruiting
        • North east london foundation trust
        • Contact:
          • trudie i rossouw, dr
          • Phone Number: +448446001200
        • Principal Investigator:
          • trudie i rossouw, dr

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

12 years to 17 years (CHILD)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • all young people who are admitted to Brookside adolescent unit between the ages 12 - 17 presenting with depression and emerging personality disorder will be eligible

Exclusion Criteria:

  • Young people with autistic spectrum disorders or severe learning disabilities.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: TREATMENT
  • Allocation: NON_RANDOMIZED
  • Interventional Model: PARALLEL
  • Masking: SINGLE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
EXPERIMENTAL: MBT group
mentalization based treatment program
Other: MBT
The intervention consists of twice weekly individual MBT therapy, group therapy with an MBT focus and weekly MBFT, which is MBT for families. The treatment duration will be 6-8 weeks.
Other Names:
  • Psychotherapeutic program
ACTIVE_COMPARATOR: Treatment as usual group
treatment as usual group
Other: treatment as usual
less intensive and structured psychotherapeutic program
Other Names:
  • Psychotherapeutic program

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Global assessment of functioning
Time Frame: 2 years post discharge
Measures global functioning
2 years post discharge
Global assessment of functioning
Time Frame: within 1 week of admission
measures level of functioning
within 1 week of admission
global assessment of functioning
Time Frame: Average of 8 weeks
measures level of functioning
Average of 8 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
mood and feelings questionnaire
Time Frame: 2 years post discharge
Assesses mood in terms of number of depressive symptoms
2 years post discharge
Mood and feelings questionnaire
Time Frame: Within 1 week of admission
Assesses mood in terms of number of depressive symptoms
Within 1 week of admission
mood and feelings questionnaire
Time Frame: At average of 8 weeks
Assesses mood in terms of number of depressive symptoms
At average of 8 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

North East London Foundation Trust

Investigators

  • Principal Investigator: trudie i rossouw, dr, North east london foundation trust

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

December 1, 2010

Primary Completion (ANTICIPATED)

December 1, 2016

Study Completion (ANTICIPATED)

December 1, 2016

Study Registration Dates

First Submitted

September 16, 2010

First Submitted That Met QC Criteria

September 16, 2010

First Posted (ESTIMATE)

September 17, 2010

Study Record Updates

Last Update Posted (ESTIMATE)

October 3, 2014

Last Update Submitted That Met QC Criteria

October 2, 2014

Last Verified

July 1, 2011

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • TRossouw

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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