- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01231828
Method of Assessment of Driving Ability in Patients Suffering From Wakefulness Pathologies. (AutoSop-Foie)
February 26, 2013 updated by: University Hospital, Caen
Method of Assessment of Driving Ability in Patients Suffering From Wakefulness Pathologies. Impact of Lactulose and Carnitine Treatment.
The project will improve scientific knowledge regarding a recent law applying potentially to every french driver.
It will give for the first time an indication on the impact of alerting treatments on driving risks.
It will reinforce the links between different research environments (sleep physiopathology, clinical research, cognitive neurosciences, drivers supervision, virtual reality, pharmacology) among the "Réseau Eveil Sommeil Attention et Transports" (RESAT) network.
Study Overview
Detailed Description
Excessive daytime sleepiness is responsible of 20% of traffic accidents and 2/3 of truck accidents on French Freeways.
Since the publication of a new law (2005 december 28th - Official Journal) regulating fitness to drive, the Maintenance of Wakefulness Test (MWT) is now mandatory to evaluate driving skills of patients suffering of excessive daytime sleepiness.
The MWT has shown a good predictability of driving handicap on simulators in patients suffering from obstructive sleep apnea syndrome.
Nevertheless no study has proven yet the predictability of the MWT regarding real and simulated driving in patients suffering from hepatic encephalopathy.
Furthermore, even if therapeutic drugs significantly improve MWT scores there is no data available concerning the impact of these drugs on fitness to drive.
Lactulose, a treatment of hepatic encephalopathy, has not been tested as a counter measure to driving impairment.
This lack of knowledge is a major handicap to evaluate driving skills of treated patients suffering from excessive daytime sleepiness.
The main objective of our project is to test the predictive value of the MWT on real and simulated driving performances in untreated and treated sleepy patients suffering from hepatic encephalopathy.
Study Type
Interventional
Enrollment (Actual)
55
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
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Caen, France, 14033
- University Hospital of Caen
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-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 80 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Cirrhosis proved by histologic or clinico-biologics criteria, whatever its severity, its stability defined by a child stable score (variation < 2 points for the last month) without any other disease which could be responsible of excessive daytime sleepiness
- driver's licence since at least 2 years
- driving more than 2000 Km/year
- registered to French national health and pensions organization
- having given their written light agreement in order to participate in the study.
Exclusion Criteria:
- Night workers
- neurologic disease
- recent strong complication (< 30 days)
- recent antibiotics or lactulose intake
- substance abusers (alcohol)
- hepatoma more than 5 cm
- disorder associated which engaged life prognostic in a short time
- glycemia fasted > 8 mmol/l
- haemoglobin < 10g/l
- neurologic or psychiatric disorders associated which affect superiors functions,
- hepatic encephalopathy stage 3 or 4
- having participated in a clinical study during the last 6 months
- drugs abusers
- unable to drive.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Carnitine
Versus placebo.
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L-carnitine 4g per day (4 bottles of 10ml).
Other Names:
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Experimental: Lactulose
Versus placebo
|
Lactulose (30-60 ml per day)
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Sleep latency during Maintenance of Wakefulness Test (MWT)
Time Frame: 40 min
|
40 min
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Nocturnal sleep quality and quantity will be measured by Polysomnography (PSG).
Time Frame: 1 night
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1 night
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Nocturnal sleep quality and quantity measured by Actimetry.
Time Frame: during 3 days
|
during 3 days
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Marie-Astrid PIQUET, University Hospital, Caen
- Study Director: Thong DAO, University Hospital, Caen
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
September 1, 2009
Primary Completion (Actual)
June 1, 2012
Study Completion (Actual)
December 1, 2012
Study Registration Dates
First Submitted
October 4, 2010
First Submitted That Met QC Criteria
October 29, 2010
First Posted (Estimate)
November 1, 2010
Study Record Updates
Last Update Posted (Estimate)
February 27, 2013
Last Update Submitted That Met QC Criteria
February 26, 2013
Last Verified
February 1, 2013
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- A90591-34
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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