- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01273701
Combination of Psychosocial Intervention and Slow Prosecutions for the Treatment of Methamphetamine Abuse/Dependence
The hospital where this study will be conducted is responsible for the one-year contingency management treatment for methamphetamine drug offenders referred from the Yunlin District Prosecutors Office. Completing the one-year treatment is prerequisite for offenders to get slow prosecutions.
It is an open-label, parallel-group trial comparing the combination of psychosocial intervention and slow prosecutions with psychosocial intervention alone in treating subjects with methamphetamine dependence
Study Hypothesis
- Psychosocial interventions in combination with slow prosecutions is more effective than psychosocial interventions alone to achieve abstinence for subjects with methamphetamine abuse/dependance.
- Inclusion of telephone reminding before each visit will enhance the retention rate and abstinence rate.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Yi-Ting Lin, M.D.
- Phone Number: 7120 +886-5-5323911
- Email: p98421013@ntu.edut.tw
Study Locations
-
-
-
Yunlin, Taiwan
- National Taiwan University Hospital Yunlin Branch
-
Contact:
- Yi-Ting Lin, M.D.
- Phone Number: 7120 +886-5-5323911
- Email: p98421013@ntu.edu.tw
-
Principal Investigator:
- Yi-Ting Lin, M.D.
-
Sub-Investigator:
- Li-Ren Chang, M.D.
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- DSM-IV-TR criteria for amphetamine/methamphetamine abuse or dependence
- 18 - 65 years old
- For TSTSU-N and TSTSU-T arms: methamphetamine offenders referred by the Yunlin District Prosecutors Office
- For OPD arm: psychiatric outpatients referred from the psychiatry clinics in National Taiwan University Hospital, Yunlin Branch
Exclusion Criteria:
- Concurrent use of other illicit substances
- Co-morbidity with major psychotic disorders (schizophrenia, schizoaffective disorder, other psychotic disorder), mental retardation, acute episodes of major depressive disorder or bipolar affective disorder) or serious personality disorders.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: NON_RANDOMIZED
- Interventional Model: PARALLEL
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: TSTSU-N
TSTSU-N stands for Treatment for Schedule Two Substance Use, No Telephone Reminding.
Subjects will be referred by the Yunlin District Prosecutors Office for one-year psychosocial interventions to get slow prosecutions.
After the referral, they will be randomized in a 1:1 ratio to either TSTSU-N group or TSTSU-T group.
During the intervention, subjects of TSTSU-N will not receive telephone reminding before each visit.
|
The treatment is one-year long and composed of 3 stages of psychosocial intervention. Subjects of TSTSU arms receive urine methamphetamine examinations at each visit, while subjects in OPD arm being tested at first/last visits and during stage changes. -Stage 1, early intensive monitoring stage: The visit interval is 1 week. If the urine tests and self-report on methamphetamine use are negative for consecutive 4 visits, subjects can proceed to stage 2. (In OPD arm, the visit interval can be 2 weeks according to subjects' requirements.) -Sage 2, late intensive monitoring stage: The visit interval is 2 week. If the urine tests and self-reports are straightly negative for 4 visits, subjects can proceed to stage 3. Whenever recent methamphetamine is detected, subjects should move back to stage 1. -Stage 3, usual monitoring stage: The visit interval is 1 month until the end of treatment. Whenever recent methamphetamine is detected, subjects should move back to stage 1.
Other Names:
|
EXPERIMENTAL: TSTSU-T
TSTSU-T stands for Treatment for Schedule Two Substance Use, Telephone Reminding.
Subjects will be referred by the Yunlin District Prosecutors Office for one-year psychosocial interventions to get slow prosecutions.
After the referral, they will be randomized in a 1:1 ratio to either TSTSU-N group or TSTSU-T group.
During the intervention, subjects of TSTSU-T will receive telephone reminding before each visit.
|
The treatment is one-year long and composed of 3 stages of psychosocial intervention. Subjects of TSTSU arms receive urine methamphetamine examinations at each visit, while subjects in OPD arm being tested at first/last visits and during stage changes. -Stage 1, early intensive monitoring stage: The visit interval is 1 week. If the urine tests and self-report on methamphetamine use are negative for consecutive 4 visits, subjects can proceed to stage 2. (In OPD arm, the visit interval can be 2 weeks according to subjects' requirements.) -Sage 2, late intensive monitoring stage: The visit interval is 2 week. If the urine tests and self-reports are straightly negative for 4 visits, subjects can proceed to stage 3. Whenever recent methamphetamine is detected, subjects should move back to stage 1. -Stage 3, usual monitoring stage: The visit interval is 1 month until the end of treatment. Whenever recent methamphetamine is detected, subjects should move back to stage 1.
Other Names:
Subjects in TSTSU-T group will receive addition telephone reminding one day before each visit.
Each call will be no longer than five minutes.
On the telephone, brief motivation enhancement may be conducted.
|
ACTIVE_COMPARATOR: OPD
OPD stands for Outpatient Department.
Subjects in this arm will be methamphetamine users who voluntarily visit psychiatric clinics for treatment of mental disorders in National Taiwan University Hospital, Yunlin Branch.
They will be referred to this study by their treating psychiatrists.
|
The treatment is one-year long and composed of 3 stages of psychosocial intervention. Subjects of TSTSU arms receive urine methamphetamine examinations at each visit, while subjects in OPD arm being tested at first/last visits and during stage changes. -Stage 1, early intensive monitoring stage: The visit interval is 1 week. If the urine tests and self-report on methamphetamine use are negative for consecutive 4 visits, subjects can proceed to stage 2. (In OPD arm, the visit interval can be 2 weeks according to subjects' requirements.) -Sage 2, late intensive monitoring stage: The visit interval is 2 week. If the urine tests and self-reports are straightly negative for 4 visits, subjects can proceed to stage 3. Whenever recent methamphetamine is detected, subjects should move back to stage 1. -Stage 3, usual monitoring stage: The visit interval is 1 month until the end of treatment. Whenever recent methamphetamine is detected, subjects should move back to stage 1.
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Endpoint abstinence rate
Time Frame: At the end of one-year treatment
|
According to the urine amphetamine/methamphetamine screen after the one-year treatment, negative result suggests successful abstinence.
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At the end of one-year treatment
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Retention rate
Time Frame: during the whole one-year treatment
|
proportion of subjects who can complete the course of one-year treatment
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during the whole one-year treatment
|
Length of retention
Time Frame: during the whole one-year treatment
|
the averaged duration of attending treatment
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during the whole one-year treatment
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The longest period of abstinence
Time Frame: during the whole one-year treatment
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the longest period of time with successive negative results of urine amphetamine/methamphetamine tests or negative reports of recent methamphetamine use
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during the whole one-year treatment
|
Collaborators and Investigators
Investigators
- Principal Investigator: Yi-Ting Lin, M.D., Department of Psychiatry, National Taiwan University Hospital Yunlin Branch
Study record dates
Study Major Dates
Study Start
Primary Completion (ANTICIPATED)
Study Completion (ANTICIPATED)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ESTIMATE)
Study Record Updates
Last Update Posted (ESTIMATE)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 201011014RB
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