- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01376024
Basal Joint Arthritis Prospective (BJAM)
Multicenter Prospective Study on Basal Joint Arthritis of the Thumb
The study hypothesizes that there exist effective non-operative and operative treatments for certain patient populations with basal joint arthritis of the thumb. There also exists a functionally superior, cost effective, and low risk non-operative or minimally invasive operative treatment regime to alleviate pain and slow the progression of disease in those with less advanced disease. Likewise, there is significant functional, health utility, and economic advantage to surgically treating advanced basal joint arthritis with one of the popularized procedures currently in practice.
Arthritis at the base of the thumb is a common condition associated with considerable patient discomfort. Many non-operative and operative treatments have been described, but few prospective studies involving multiple centers comparing these treatments have been done. By following patients from the start of their arthritis treatment and assessing their progress at certain time points using questionnaires and radiographs the investigators believe patient outcomes and satisfaction can improve. This study will include patients who are treated non-operatively and operatively and will not change patients' standard of care. By establishing standardized outcome measures and collecting data prospectively from the time of initial presentation through all treatment interventions it will be possible to directly compare treatments during the conservative and operative care of basal joint arthritis of the thumb. This multi-center study will identify those specific procedures or conservative treatments that have the greatest potential to be studied in subsequent focused and well-designed randomized control trials.
Study Overview
Status
Detailed Description
Basal joint arthritis of the thumb is a common condition associated with considerable morbidity. Many non-operative and operative treatments have been described but few multi-center prospective evidence based trials comparing standard treatments have been done. This continuing search for consensus of best clinical practices has been reviewed in a thorough meta-analysis of operative treatments for basal joint arthritis. Through the systematic collection of data regarding patient-specific characteristics, treatment interventions, and longitudinal functional outcome measurements the investigators believe patient outcomes and satisfaction can improve through the elucidation of risk factors for disease progression, and the timing and selection of treatment modalities, either conservative or surgical, for any particular patient. The establishment of a multi-center clinical registry will greatly facilitate these goals. By establishing standardized outcome measures and collecting data prospectively from the time of initial presentation through all treatment interventions it will be possible to directly compare treatments during the conservative and operative care of basal joint arthritis of the thumb. This proposed multi-center registry will identify those specific procedures or conservative treatments that have the most potential to be studied in subsequent focused and well-designed randomized control trials.
Osteoarthritis is the most common form of arthritis and the second most frequent cause of long-term disability in North America. Osteoarthritis of the basal joint of the thumb is a debilitating disease that affects a large segment of the adult population, although no large epidemiologic studies on the prevalence of basal joint arthritis have been performed in the United States.
The pathogenesis of osteoarthritis remains multi-factorial but most researchers agree that it is a degenerative process resulting from mechanical, biochemical, and genetic factors that destabilize the normal balance of degradation and synthesis of articular cartilage and subchondral bone.
Although there are some excellent studies with randomized, prospective design showing good outcomes with several surgical techniques, it is still unknown which procedures are the most appropriate for a particular patient to achieve the optimal functional outcome and long-term success with minimal surgical trauma. Optimal immobilization type and duration is also not known. The effect of metacarpalphalangeal joint hyperextension on long-term outcomes and the optimal treatment method for this adjacent joint is also unknown. This proposed study will allow prospective data collection from multiple institutions across the country and engage recognized experts, all of whom treat basal joint arthritis with different clinical protocols.
Millions of people in the U.S. have or will develop basal joint osteoarthritis, which is the most commonly affected joint in the upper extremity that requires surgical intervention. The demand for a more efficacious and cost effective form of operative and non-operative treatment of this disabling disease is considerable. Identifying safe and effective treatments from among the numerous treatment modalities available would likely lead to significant improvements in the quality of life for a large segment of this population. If future studies show less involved reconstructions, such as trapeziectomy alone, are as effective as more complicated ligament reconstructions with tendon interposition, many patients may benefit from this less complex surgery. This trial would increase clinician and patient awareness and confidence in effective treatment regimens.
This study hypothesizes that there exist effective non-operative and operative treatments for certain patient populations with basal joint arthritis of the thumb. There also exists a functionally superior, cost effective, and low risk non-operative or minimally invasive operative treatment regime to alleviate pain and slow the progression of disease in those with less advanced disease. Likewise, there is a significant functional, health utility, and economic advantage to surgically treating advanced basal joint arthritis of the thumb with one of the popularized procedures currently in practice.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: John W Karl, MD, MPH
- Phone Number: 212-305-3912
- Email: jwk2115@columbia.edu
Study Locations
-
-
New York
-
New York, New York, United States, 10032
- Recruiting
- Columbia University/NY Presbyterian Hospital
-
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Patients who have symptomatic basal joint arthritis.
- Patients who are capable of providing informed consent
Exclusion Criteria:
- Patients younger than 18 years old at the time of enrollment
- Patients with neuromuscular disease affecting the operated hand, not caused by the CMC operation
- Patients with known inflammatory arthritic conditions, such as rheumatoid or psoriatic arthritis
- Patients with a history of or current infection of the basal joint of the affected hand.
- Patients who are demented or are unable to provide informed consent.
- Patients unable to comply with study guidelines.
- Patients who have metacarpophalangeal joint hyperextension are NOT excluded. These patients will be followed and if they receive a capsulodesis or other procedure at the MCPJ at the same time as their basal joint arthroplasty this will be noted in their data records.
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Pain Relief
Time Frame: Initially, up to 1 year
|
Subject may have annual assessments after the 1st year.
|
Initially, up to 1 year
|
Functional strength-dexterity
Time Frame: Initially, up to 1 year
|
Subject may have annual assessments after the 1st year.
|
Initially, up to 1 year
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Cost effectiveness
Time Frame: Initially, up to 1 year
|
Subject may have annual assessments after the 1st year.
|
Initially, up to 1 year
|
Patient satisfaction
Time Frame: Initially, up to 1 year
|
Subject may have annual assessments after the 1st year.
|
Initially, up to 1 year
|
Collaborators and Investigators
Sponsor
Publications and helpful links
General Publications
- Lawrence RC, Helmick CG, Arnett FC, Deyo RA, Felson DT, Giannini EH, Heyse SP, Hirsch R, Hochberg MC, Hunder GG, Liang MH, Pillemer SR, Steen VD, Wolfe F. Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum. 1998 May;41(5):778-99. doi: 10.1002/1529-0131(199805)41:53.0.CO;2-V.
- McHorney CA, Ware JE Jr, Raczek AE. The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. Med Care. 1993 Mar;31(3):247-63. doi: 10.1097/00005650-199303000-00006.
- Creamer P, Hochberg MC. Osteoarthritis. Lancet. 1997 Aug 16;350(9076):503-8. doi: 10.1016/S0140-6736(97)07226-7. No abstract available.
- Jebsen RH, Taylor N, Trieschmann RB, Trotter MJ, Howard LA. An objective and standardized test of hand function. Arch Phys Med Rehabil. 1969 Jun;50(6):311-9. No abstract available.
- Martou G, Veltri K, Thoma A. Surgical treatment of osteoarthritis of the carpometacarpal joint of the thumb: a systematic review. Plast Reconstr Surg. 2004 Aug;114(2):421-32. doi: 10.1097/01.prs.0000131989.86319.b1.
- Gervis WH, Wells T. A review of excision of the trapezium for osteoarthritis of the trapezio-metacarpal joint after twenty-five years. J Bone Joint Surg Br. 1973 Feb;55(1):56-7. No abstract available.
- Kuhns CA, Emerson ET, Meals RA. Hematoma and distraction arthroplasty for thumb basal joint osteoarthritis: a prospective, single-surgeon study including outcomes measures. J Hand Surg Am. 2003 May;28(3):381-9. doi: 10.1053/jhsu.2003.50078.
- Eaton RG, Littler JW. Ligament reconstruction for the painful thumb carpometacarpal joint. J Bone Joint Surg Am. 1973 Dec;55(8):1655-66. No abstract available.
- Armstrong AL, Hunter JB, Davis TR. The prevalence of degenerative arthritis of the base of the thumb in post-menopausal women. J Hand Surg Br. 1994 Jun;19(3):340-1. doi: 10.1016/0266-7681(94)90085-x.
- Burton RI, Pellegrini VD Jr. Surgical management of basal joint arthritis of the thumb. Part II. Ligament reconstruction with tendon interposition arthroplasty. J Hand Surg Am. 1986 May;11(3):324-32. doi: 10.1016/s0363-5023(86)80137-x.
- GERVIS WH. Excision of the trapezium for osteoarthritis of the trapezio-metacarpal joint. J Bone Joint Surg Br. 1949 Nov;31B(4):537-9, illust. No abstract available.
- Tomaino MM, Pellegrini VD Jr, Burton RI. Arthroplasty of the basal joint of the thumb. Long-term follow-up after ligament reconstruction with tendon interposition. J Bone Joint Surg Am. 1995 Mar;77(3):346-55. doi: 10.2106/00004623-199503000-00003.
- Detsky AS, Naglie IG. A clinician's guide to cost-effectiveness analysis. Ann Intern Med. 1990 Jul 15;113(2):147-54. doi: 10.7326/0003-4819-113-2-147.
- Davis TR, Brady O, Dias JJ. Excision of the trapezium for osteoarthritis of the trapeziometacarpal joint: a study of the benefit of ligament reconstruction or tendon interposition. J Hand Surg Am. 2004 Nov;29(6):1069-77. doi: 10.1016/j.jhsa.2004.06.017.
- Ware JE Jr, Kosinski M, Bayliss MS, McHorney CA, Rogers WH, Raczek A. Comparison of methods for the scoring and statistical analysis of SF-36 health profile and summary measures: summary of results from the Medical Outcomes Study. Med Care. 1995 Apr;33(4 Suppl):AS264-79.
- Poole JU, Pellegrini VD Jr. Arthritis of the thumb basal joint complex. J Hand Ther. 2000 Apr-Jun;13(2):91-107. doi: 10.1016/s0894-1130(00)80034-4.
- Lawrence JS, Bremner JM, Bier F. Osteo-arthrosis. Prevalence in the population and relationship between symptoms and x-ray changes. Ann Rheum Dis. 1966 Jan;25(1):1-24. No abstract available.
- Nicholas RM, Calderwood JW. De la Caffiniere arthroplasty for basal thumb joint osteoarthritis. J Bone Joint Surg Br. 1992 Mar;74(2):309-12. doi: 10.1302/0301-620X.74B2.1544976.
- Bagge E, Bjelle A, Eden S, Svanborg A. Factors associated with radiographic osteoarthritis: results from the population study 70-year-old people in Goteborg. J Rheumatol. 1991 Aug;18(8):1218-22.
- Pellegrini VD Jr. Osteoarthritis at the base of the thumb. Orthop Clin North Am. 1992 Jan;23(1):83-102.
- Barron OA, Glickel SZ, Eaton RG. Basal joint arthritis of the thumb. J Am Acad Orthop Surg. 2000 Sep-Oct;8(5):314-23. doi: 10.5435/00124635-200009000-00005.
- Pagalidis T, Kuczynski K, Lamb DW. Ligamentous stability of the base of the thumb. Hand. 1981 Feb;13(1):29-36. doi: 10.1016/s0072-968x(81)80026-5.
- Pomerance JF. Painful basal joint arthritis of the thumb. Part II: Treatment. Am J Orthop (Belle Mead NJ). 1995 Jun;24(6):466-72.
- Cooney WP 3rd, Chao EY. Biomechanical analysis of static forces in the thumb during hand function. J Bone Joint Surg Am. 1977 Jan;59(1):27-36.
- Pellegrini VD Jr, Smith RL, Ku CW. Pathobiology of articular cartilage in trapeziometacarpal osteoarthritis. I. Regional biochemical analysis. J Hand Surg Am. 1994 Jan;19(1):70-8. doi: 10.1016/0363-5023(94)90226-7.
- Pellegrini VD Jr, Smith RL, Ku CW. Pathobiology of articular cartilage in trapeziometacarpal osteoarthritis. II. Surface ultrastructure by scanning electron microscopy. J Hand Surg Am. 1994 Jan;19(1):79-85. doi: 10.1016/0363-5023(94)90227-5.
- Pellegrini VD Jr. Osteoarthritis of the trapeziometacarpal joint: the pathophysiology of articular cartilage degeneration. I. Anatomy and pathology of the aging joint. J Hand Surg Am. 1991 Nov;16(6):967-74. doi: 10.1016/s0363-5023(10)80054-1.
- Xu L, Strauch RJ, Ateshian GA, Pawluk RJ, Mow VC, Rosenwasser MP. Topography of the osteoarthritic thumb carpometacarpal joint and its variations with regard to gender, age, site, and osteoarthritic stage. J Hand Surg Am. 1998 May;23(3):454-64. doi: 10.1016/S0363-5023(05)80463-0.
- Swigart CR, Eaton RG, Glickel SZ, Johnson C. Splinting in the treatment of arthritis of the first carpometacarpal joint. J Hand Surg Am. 1999 Jan;24(1):86-91. doi: 10.1053/jhsu.1999.jhsu24a0086.
- Creamer P, Flores R, Hochberg MC. Management of osteoarthritis in older adults. Clin Geriatr Med. 1998 Aug;14(3):435-54.
- Melone CP Jr, Beavers B, Isani A. The basal joint pain syndrome. Clin Orthop Relat Res. 1987 Jul;(220):58-67.
- Lane LB, Eaton RG. Ligament reconstruction for the painful "prearthritic" thumb carpometacarpal joint. Clin Orthop Relat Res. 1987 Jul;(220):52-7.
- Berggren M, Joost-Davidsson A, Lindstrand J, Nylander G, Povlsen B. Reduction in the need for operation after conservative treatment of osteoarthritis of the first carpometacarpal joint: a seven year prospective study. Scand J Plast Reconstr Surg Hand Surg. 2001 Dec;35(4):415-7. doi: 10.1080/028443101317149381.
- Meenagh GK, Patton J, Kynes C, Wright GD. A randomised controlled trial of intra-articular corticosteroid injection of the carpometacarpal joint of the thumb in osteoarthritis. Ann Rheum Dis. 2004 Oct;63(10):1260-3. doi: 10.1136/ard.2003.015438.
- Day CS, Gelberman R, Patel AA, Vogt MT, Ditsios K, Boyer MI. Basal joint osteoarthritis of the thumb: a prospective trial of steroid injection and splinting. J Hand Surg Am. 2004 Mar;29(2):247-51. doi: 10.1016/j.jhsa.2003.12.002.
- Joshi R. Intraarticular corticosteroid injection for first carpometacarpal osteoarthritis. J Rheumatol. 2005 Jul;32(7):1305-6.
- Stahl S, Karsh-Zafrir I, Ratzon N, Rosenberg N. Comparison of intraarticular injection of depot corticosteroid and hyaluronic acid for treatment of degenerative trapeziometacarpal joints. J Clin Rheumatol. 2005 Dec;11(6):299-302. doi: 10.1097/01.rhu.0000191194.39926.c9.
- Buurke JH, Grady JH, de Vries J, Baten CT. Usability of thenar eminence orthoses: report of a comparative study. Clin Rehabil. 1999 Aug;13(4):288-94. doi: 10.1191/026921599671603077.
- Weiss S, Lastayo P, Mills A, Bramlet D. Splinting the degenerative basal joint: custom-made or prefabricated neoprene? J Hand Ther. 2004 Oct-Dec;17(4):401-6.
- Heyworth BE, Lee JH, Kim PD, Lipton CB, Strauch RJ, Rosenwasser MP. Hylan versus corticosteroid versus placebo for treatment of basal joint arthritis: a prospective, randomized, double-blinded clinical trial. J Hand Surg Am. 2008 Jan;33(1):40-8. doi: 10.1016/j.jhsa.2007.10.009.
- Pellegrini VD Jr, Olcott CW, Hollenberg G. Contact patterns in the trapeziometacarpal joint: the role of the palmar beak ligament. J Hand Surg Am. 1993 Mar;18(2):238-44. doi: 10.1016/0363-5023(93)90354-6.
- Tomaino MM. Treatment of Eaton stage I trapeziometacarpal disease. Ligament reconstruction or thumb metacarpal extension osteotomy? Hand Clin. 2001 May;17(2):197-205.
- Bettinger PC, Linscheid RL, Berger RA, Cooney WP 3rd, An KN. An anatomic study of the stabilizing ligaments of the trapezium and trapeziometacarpal joint. J Hand Surg Am. 1999 Jul;24(4):786-98. doi: 10.1053/jhsu.1999.0786.
- Hooper GJ. An unusual variety of skier's thumb. J Hand Surg Am. 1987 Jul;12(4):627-9. doi: 10.1016/s0363-5023(87)80224-1.
- Shah J, Patel M. Dislocation of the carpometacarpal joint of the thumb. A report of four cases. Clin Orthop Relat Res. 1983 May;(175):166-9.
- Strauch RJ, Behrman MJ, Rosenwasser MP. Acute dislocation of the carpometacarpal joint of the thumb: an anatomic and cadaver study. J Hand Surg Am. 1994 Jan;19(1):93-8. doi: 10.1016/0363-5023(94)90229-1.
- Eaton RG, Lane LB, Littler JW, Keyser JJ. Ligament reconstruction for the painful thumb carpometacarpal joint: a long-term assessment. J Hand Surg Am. 1984 Sep;9(5):692-99. doi: 10.1016/s0363-5023(84)80015-5.
- Freedman DM, Eaton RG, Glickel SZ. Long-term results of volar ligament reconstruction for symptomatic basal joint laxity. J Hand Surg Am. 2000 Mar;25(2):297-304. doi: 10.1053/jhsu.2000.jhsu25a0297.
- Shrivastava N, Koff MF, Abbot AE, Mow VC, Rosenwasser MP, Strauch RJ. Simulated extension osteotomy of the thumb metacarpal reduces carpometacarpal joint laxity in lateral pinch. J Hand Surg Am. 2003 Sep;28(5):733-8. doi: 10.1016/s0363-5023(03)00256-9.
- Kadiyala RK, Gelberman RH, Kwon B. Radiographic assessment of the trapezial space before and after ligament reconstruction and tendon interposition arthroplasty. J Hand Surg Br. 1996 Apr;21(2):177-81. doi: 10.1016/s0266-7681(96)80093-3.
- Weilby A. Surgical treatment of osteoarthritis of the carpo-meta-carpal joint of the thumb. Acta Orthop Scand. 1971;42(5):439-40. No abstract available.
- Weilby A. Surgical treatment of osteoarthritis of the carpo-metacarpal joint of the thumb. Indications for arthrodesis, excision of the trapezium, and alloplasty. Scand J Plast Reconstr Surg. 1971;5(2):136-41. doi: 10.3109/02844317109042954. No abstract available.
- Van Innis F, Thys R, Lebrun A, Hollaert G, Detournay M. [Trapeziectomy in rhizarthrosis]. Ann Chir Main. 1983;2(4):365-7. doi: 10.1016/s0753-9053(83)80048-9. French.
- Dhar S, Gray IC, Jones WA, Beddow FH. Simple excision of the trapezium for osteoarthritis of the carpometacarpal joint of the thumb. J Hand Surg Br. 1994 Aug;19(4):485-8. doi: 10.1016/0266-7681(94)90214-3.
- Iyer KM. The results of excision of the trapezium. Hand. 1981 Oct;13(3):246-50. doi: 10.1016/s0072-968x(81)80004-6.
- Kvarnes L, Reikeras O. Osteoarthritis of the carpometacarpal joint of the thumb. An analysis of operative procedures. J Hand Surg Br. 1985 Feb;10(1):117-20. doi: 10.1016/s0266-7681(85)80037-1.
- Vandenbroucke J, De Schrijver F, De Smet L, Fabry G. Simple trapezectomy for treatment of trapeziometacarpal osteoarthritis of the thumb. Clin Rheumatol. 1997 May;16(3):239-42. doi: 10.1007/BF02238957.
- Diao E. Trapezio-metacarpal arthritis. Trapezium excision and ligament reconstruction not including the LRTI arthroplasty. Hand Clin. 2001 May;17(2):223-36, ix.
- Dell PC, Brushart TM, Smith RJ. Treatment of trapeziometacarpal arthritis: results of resection arthroplasty. J Hand Surg Am. 1978 May;3(3):243-9. doi: 10.1016/s0363-5023(78)80088-4.
- Robinson D, Aghasi M, Halperin N. Abductor pollicis longus tendon arthroplasty of the trapezio-metacarpal joint: surgical technique and results. J Hand Surg Am. 1991 May;16(3):504-9. doi: 10.1016/0363-5023(91)90023-5.
- Dell PC, Muniz RB. Interposition arthroplasty of the trapeziometacarpal joint for osteoarthritis. Clin Orthop Relat Res. 1987 Jul;(220):27-34.
- Yang SS, Weiland AJ. First metacarpal subsidence during pinch after ligament reconstruction and tendon interposition basal joint arthroplasty of the thumb. J Hand Surg Am. 1998 Sep;23(5):879-83. doi: 10.1016/S0363-5023(98)80167-6.
- Kriegs-Au G, Petje G, Fojtl E, Ganger R, Zachs I. Ligament reconstruction with or without tendon interposition to treat primary thumb carpometacarpal osteoarthritis. A prospective randomized study. J Bone Joint Surg Am. 2004 Feb;86(2):209-18. doi: 10.2106/00004623-200402000-00001.
- Lins RE, Gelberman RH, McKeown L, Katz JN, Kadiyala RK. Basal joint arthritis: trapeziectomy with ligament reconstruction and tendon interposition arthroplasty. J Hand Surg Am. 1996 Mar;21(2):202-9. doi: 10.1016/S0363-5023(96)80101-8.
- Barron OA, Eaton RG. Save the trapezium: double interposition arthroplasty for the treatment of stage IV disease of the basal joint. J Hand Surg Am. 1998 Mar;23(2):196-204. doi: 10.1016/S0363-5023(98)80114-7.
- Davis TR, Brady O, Barton NJ, Lunn PG, Burke FD. Trapeziectomy alone, with tendon interposition or with ligament reconstruction? J Hand Surg Br. 1997 Dec;22(6):689-94. doi: 10.1016/s0266-7681(97)80426-3.
- Downing ND, Davis TR. Trapezial space height after trapeziectomy: mechanism of formation and benefits. J Hand Surg Am. 2001 Sep;26(5):862-8. doi: 10.1053/jhsu.2001.27761.
- Horlock N, Belcher HJ. Early versus late mobilisation after simple excision of the trapezium. J Bone Joint Surg Br. 2002 Nov;84(8):1111-5. doi: 10.1302/0301-620x.84b8.12993.
- Gerwin M, Griffith A, Weiland AJ, Hotchkiss RN, McCormack RR. Ligament reconstruction basal joint arthroplasty without tendon interposition. Clin Orthop Relat Res. 1997 Sep;(342):42-5.
- Tagil M, Kopylov P. Swanson versus APL arthroplasty in the treatment of osteoarthritis of the trapeziometacarpal joint: a prospective and randomized study in 26 patients. J Hand Surg Br. 2002 Oct;27(5):452-6. doi: 10.1054/jhsb.2002.0836.
- Belcher HJ, Nicholl JE. A comparison of trapeziectomy with and without ligament reconstruction and tendon interposition. J Hand Surg Br. 2000 Aug;25(4):350-6. doi: 10.1054/jhsb.2000.0431.
- Conolly WB, Rath S. Revision procedures for complications of surgery for osteoarthritis of the carpometacarpal joint of the thumb. J Hand Surg Br. 1993 Aug;18(4):533-9. doi: 10.1016/0266-7681(93)90166-d.
- De Smet L, Sioen W, Spaepen D, van Ransbeeck H. Treatment of basal joint arthritis of the thumb: trapeziectomy with or without tendon interposition/ligament reconstruction. Hand Surg. 2004 Jul;9(1):5-9. doi: 10.1142/s0218810404001942.
- Eaton RG, Littler JW. A study of the basal joint of the thumb. Treatment of its disabilities by fusion. J Bone Joint Surg Am. 1969 Jun;51(4):661-8. No abstract available.
- Mattsson HS. Arthrodesis of the first carpo-metacarpal joint for osteoarthritis. Acta Orthop Scand. 1969;40(5):602-7. doi: 10.3109/17453676908989525. No abstract available.
- Carroll RE. Arthrodesis of the carpometacarpal joint of the thumb. A review of patients with a long postoperative period. Clin Orthop Relat Res. 1987 Jul;(220):106-10.
- Bamberger HB, Stern PJ, Kiefhaber TR, McDonough JJ, Cantor RM. Trapeziometacarpal joint arthrodesis: a functional evaluation. J Hand Surg Am. 1992 Jul;17(4):605-11. doi: 10.1016/0363-5023(92)90302-6.
- Hartigan BJ, Stern PJ, Kiefhaber TR. Thumb carpometacarpal osteoarthritis: arthrodesis compared with ligament reconstruction and tendon interposition. J Bone Joint Surg Am. 2001 Oct;83(10):1470-8. doi: 10.2106/00004623-200110000-00002.
- Mureau MA, Rademaker RP, Verhaar JA, Hovius SE. Tendon interposition arthroplasty versus arthrodesis for the treatment of trapeziometacarpal arthritis: a retrospective comparative follow-up study. J Hand Surg Am. 2001 Sep;26(5):869-76. doi: 10.1053/jhsu.2001.26659.
- Ashworth CR, Blatt G, Chuinard RG, Stark HH. Silicone-rubber interposition arthroplasty of the carpometacarpal joint of the thumb. J Hand Surg Am. 1977 Sep;2(5):345-57. doi: 10.1016/s0363-5023(77)80044-0.
- August AC, Coupland RM, Sandifer JP. Short term review of the De La Caffiniere trapeziometacarpal arthroplasty. J Hand Surg Br. 1984 Jun;9(2):185-8.
- Eaton RG. Replacement of the trapezium for arthritis of the basal articulations: a new technique with stabilization by tenodesis. J Bone Joint Surg Am. 1979 Jan;61(1):76-82.
- Ruffin RA, Rayan GM. Treatment of trapeziometacarpal arthritis with silastic and metallic implant arthroplasty. Hand Clin. 2001 May;17(2):245-53, ix.
- Braun RM. Total joint arthroplasty at the carpometacarpal joint of the thumb. Clin Orthop Relat Res. 1985 May;(195):161-7.
- Wachtl SW, Guggenheim PR, Sennwald GR. [Radiological course of cemented and uncemented trapeziometacarpal prostheses]. Ann Chir Main Memb Super. 1997;16(3):222-8. doi: 10.1016/s0753-9053(97)80005-1. French.
- Wachtl SW, Sennwald GR, Ochsner PE, Von Hochstetter AR, Spycher MA. Analysis of two bone-prosthesis interfaces and membranes from non-cemented trapeziometacarpal prostheses. Ann Chir Main Memb Super. 1999;18(1):66-72. doi: 10.1016/s0753-9053(99)80058-1.
- Athwal GS, Chenkin J, King GJ, Pichora DR. Early failures with a spheric interposition arthroplasty of the thumb basal joint. J Hand Surg Am. 2004 Nov;29(6):1080-4. doi: 10.1016/j.jhsa.2004.06.012.
- Carter PR, Benton LJ, Dysert PA. Silicone rubber carpal implants: a study of the incidence of late osseous complications. J Hand Surg Am. 1986 Sep;11(5):639-44. doi: 10.1016/s0363-5023(86)80003-x.
- Peimer CA. Long-term complications of trapeziometacarpal silicone arthroplasty. Clin Orthop Relat Res. 1987 Jul;(220):86-98.
- Peimer CA, Medige J, Eckert BS, Wright JR, Howard CS. Reactive synovitis after silicone arthroplasty. J Hand Surg Am. 1986 Sep;11(5):624-38. doi: 10.1016/s0363-5023(86)80002-8.
- Berger RA. A technique for arthroscopic evaluation of the first carpometacarpal joint. J Hand Surg Am. 1997 Nov;22(6):1077-80. doi: 10.1016/S0363-5023(97)80052-4.
- Menon J. Arthroscopic management of trapeziometacarpal joint arthritis of the thumb. Arthroscopy. 1996 Oct;12(5):581-7. doi: 10.1016/s0749-8063(96)90198-x.
- Menon J. Arthroscopic evaluation of the first carpometacarpal joint. J Hand Surg Am. 1998 Jul;23(4):757. doi: 10.1016/S0363-5023(98)80067-1. No abstract available.
- Orellana MA, Chow JC. Arthroscopic visualization of the thumb carpometacarpal joint: introduction and evaluation of a new radial portal. Arthroscopy. 2003 Jul-Aug;19(6):583-91. doi: 10.1016/s0749-8063(03)00119-1.
- Walsh EF, Akelman E, Fleming BC, DaSilva MF. Thumb carpometacarpal arthroscopy: a topographic, anatomic study of the thenar portal. J Hand Surg Am. 2005 Mar;30(2):373-9. doi: 10.1016/j.jhsa.2004.11.011.
- Culp RW, Rekant MS. The role of arthroscopy in evaluating and treating trapeziometacarpal disease. Hand Clin. 2001 May;17(2):315-9, x-xi.
- De Smet L. Responsiveness of the DASH score in surgically treated basal joint arthritis of the thumb: preliminary results. Clin Rheumatol. 2004 Jun;23(3):223-4. doi: 10.1007/s10067-004-0866-y. Epub 2004 Mar 25.
- Eaton RG, Glickel SZ. Trapeziometacarpal osteoarthritis. Staging as a rationale for treatment. Hand Clin. 1987 Nov;3(4):455-71.
- Nusem I, Goodwin DR. Excision of the trapezium and interposition arthroplasty with gelfoam for the treatment of trapeziometacarpal osteoarthritis. J Hand Surg Br. 2003 Jun;28(3):242-5. doi: 10.1016/s0266-7681(03)00009-3.
- Massy-Westropp N, Ahern M, Krishnan J. A visual analogue scale for assessment of the impact of rheumatoid arthritis in the hand: validity and repeatability. J Hand Ther. 2005 Jan-Mar;18(1):30-3. doi: 10.1197/j.jht.2004.10.003.
- Heyworth BE, Jobin CM, Monica JT, Crow SA, Lee JH, Rosenwasser MP. Long-term follow-up of basal joint resection arthroplasty of the thumb with transfer of the abductor pollicis brevis origin to the flexor carpi radialis tendon. J Hand Surg Am. 2009 Jul-Aug;34(6):1021-8. doi: 10.1016/j.jhsa.2009.03.016.
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- AAAC0826
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Clinical Trials on Osteoarthrosis of the Carpometacarpal Joint of the Thumb
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Cedars-Sinai Medical CenterMusculoskeletal Transplant FoundationCompletedOsteoarthrosis of the Carpometacarpal Joint of the ThumbUnited States
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University of UtahCompletedOsteoarthrosis of the Carpometacarpal Joint of the ThumbUnited States
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Schulthess KlinikCompletedOsteoarthrosis of the Carpometacarpal Joint of the ThumbSwitzerland
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Oslo University HospitalCompletedOsteoarthrosis of the Carpometacarpal Joint of the ThumbNorway
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Schulthess KlinikLeiden University Medical CenterCompletedOsteoarthrosis of the Carpometacarpal Joint of the ThumbSwitzerland
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Brent DeGeorgeNot yet recruitingArthritis of Carpometacarpal Joint of Left Thumb | Arthritis of Carpometacarpal Joint of Right Thumb
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University of AlbertaRecruitingThumb Osteoarthritis | Osteoarthritis of the Carpometacarpal JointCanada
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Schulthess KlinikCompletedJoint Instability | Osteoarthritis Thumb | Arthrosis of First Carpometacarpal JointSwitzerland
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Schulthess KlinikCompletedJoint Diseases | Osteoarthritis | Musculoskeletal Diseases or Conditions | Osteoarthritis Thumb | Arthrosis of First Carpometacarpal JointSwitzerland
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Smith & Nephew, Inc.RecruitingAdvanced Degeneration of the Hip Joint | Revision of the Hip JointUnited States, Canada, Australia, Hong Kong, India