Evaluation of TRC105 in the Treatment of Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Carcinoma

A Phase 2 Evaluation of TRC105 in the Treatment of Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Carcinoma

The purpose of this study is to evaluate the safety and efficacy of TRC105 in patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma.

Study Overview

• Status: Completed
• Conditions: Fallopian Tube Carcinoma; Primary Peritoneal Carcinoma; Recurrent Ovarian Cancer
• Intervention / Treatment: Biological: Carotuximab (TRC105)

Detailed Description

Angiogenesis plays a central role in the progression of epithelial ovarian cancer. In mouse models, VEGF-inhibitors diminish ovarian tumor growth, metastasis and malignant ascites formation. Independent Phase 2 trials have demonstrated single-agent activity for bevacizumab in recurrent ovarian cancer, and randomized controlled Phase 3 trials are ongoing in the first-line setting (GOG 0218 and ICON-7) and for recurrent disease (GOG 0213, OCEANS).

TRC105 is an antibody to CD105, an important non-VEGF angiogenic target on vascular endothelial cells. TRC105 inhibits angiogenesis, tumor growth and metastases in preclinical models. In a Phase 1 study of advanced solid tumors, TRC105 therapy caused a global reduction in angiogenic biomarkers and reduced tumor burden at doses that were well-tolerated. We hypothesize that TRC105 will have single-agent activity in recurrent ovarian cancer. By targeting a non-VEGF pathway, TRC105 has the potential to complement VEGF inhibitors which could represent a major advance in ovarian cancer therapy.

• Study Type: Interventional
• Enrollment (Actual): 23
• Phase: Phase 2

Contacts and Locations

Study Locations

• United States
  • Alabama
    • Birmingham, Alabama, United States, 35249
      • University of Alabama at Birmingham
  • California
    • La Jolla, California, United States, 92093
      • University of California, San Diego
    • Los Angeles, California, United States, 90033
      • University of Southern California
  • Florida
    • West Palm Beach, Florida, United States, 33401
      • Palm Beach Cancer Institute
  • Indiana
    • Indianapolis, Indiana, United States, 46202
      • Indiana University-Bren and Melvin Simon Cancer Center
  • New York
    • New York, New York, United States, 10065
      • Memorial Sloan-Kettering Cancer Center
  • Texas
    • Houston, Texas, United States, 77230
      • MD Anderson Cancer Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma
• Measurable disease per RECIST 1.1
• At least one "target lesion" per RECIST 1.1
• Patients must have GOG Performance Status of 0 or 1
• Patients must have a life expectancy of ≥ 3 months
• Resolution of all acute toxic effects of prior therapy
• Free of active infection requiring antibiotics
• Must have had one prior platinum-based chemotherapeutic regimen for management of primary disease
• Patients could have received one additional cytotoxic regimen for management of recurrent disease
• Prior therapy directed at the malignant tumor, including hormonal and immunologic agents, must be discontinued at least three weeks prior to registration. Continuation of hormone replacement therapy is permitted.
• Adequate bone marrow function, renal function, hepatic function, neurologic function, blood coagulation parameters
• Negative serum pregnancy test and effective form of contraception for patients of childbearing potential

Exclusion Criteria:

• Previous treatment with TRC105
• Current treatment on another therapeutic clinical trial
• Receipt of an investigational agent within 28 days of starting study treatment
• Serious, non-healing wounds, ulcers, or bone fractures.
• Active bleeding or pathologic conditions that carry a high risk of bleeding
• Patients with tumor involving major vessels or transmural bowel wall involvement by tumor
• Use of thrombolytic or anticoagulant agents (except heparin to maintain i.v. catheters) within 10 days prior to the first dose of TRC105
• History of deep venous thrombosis (DVT)(except patients who have received adequate anticoagulation are eligible, and may continue on anticoagulation if appropriate)
• History of peptic ulcer disease or erosive gastritis within the past 6 months
• Known active viral or nonviral hepatitis
• History or evidence of CNS disease
• Clinically significant cardiovascular disease
• Known hypersensitivity to Chinese hamster ovary cell products or other recombinant human, chimeric, or humanized antibodies
• Pregnant or nursing
• Under the age of 18
• Patients with or with anticipation of invasive procedures including major surgical procedure, open biopsy or significant traumatic injury within 28 days prior to treatment with TRC105
• History of other invasive malignancies, except non-melanoma skin cancer and other cancers that have been treated with no evidence of disease within the last 3 years
• History of primary endometrial cancer diagnosed within the last 5 years, unless all of the following conditions are met: Stage not greater than I-B; no more than superficial myometrial invasion, without vascular or lymphatic invasion; no poorly differentiated subtypes, including papillary serous, clear cell or other FIGO Grade 3 lesions
• Patients who have received prior chemotherapy for any abdominal or pelvic tumor OTHER THAN for the treatment of ovarian, fallopian tube, or primary peritoneal cancer within the last five years are excluded. Patients may have received prior adjuvant chemotherapy for localized breast cancer, provided that it was completed > 3 years prior to registration, and patient remains free of recurrent or metastatic disease
• Prior radiotherapy to any portion of the abdominal cavity or pelvis
• Patients with clinical symptoms or signs of gastrointestinal obstruction and who require parenteral hydration and/or nutrition

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Carotuximab (TRC105) alone; Single arm, open label Carotuximab (TRC105) alone therapy dosed at 10 mg/kg administered intravenously over 1 to 4 hours on days 1, 8, 15 and 22 of each 28 day cycle	Biological: Carotuximab (TRC105); Carotuximab (TRC105) 10 mg/kg weekly by intravenous administration on Days 1, 8, 15 and 22 of each 28-day cycle; Other Names: TRC105; NSC#754227

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Progression-free Survival Rate After 6 Months of Treatment on Study	Number of patients ongoing within the study who have not progressed after 6 months of treatment	6 months
Proportion of Patients Who Have Objective Tumor Response	Proportion of patients who have objective tumor response (complete or partial) by RECIST 1.1	Every 2 cycles
Adverse Events	Frequency of adverse events as assessed by NCI CTCAE (Version 4.0)	28 days

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
CA-125 Response Rate	CA-125 response rate by GCIG criteria	Every 2 cycles
Serum Concentrations of TRC105	Median peak and trough concentration of TRC105 by ELISA in ug/mL	Cycle 1 Day 15
TRC105 Immunogenicity	TRC105 Anti-Drug Antibody (ADA) Immunogenicity by ELISA	1 year
Severity of Adverse Events	Severity of adverse events by NCI CTCAE	28 days post last dose of TRC105
Overall Survival	Median overall survival	2 years

Collaborators and Investigators

• Sponsor: Tracon Pharmaceuticals Inc.
• Investigators: Study Director: Charles P Theuer, MD, TRACON Pharmaceuticals

Study record dates

Study Major Dates

• Study Start: July 1, 2011
• Primary Completion (Actual): August 1, 2012
• Study Completion (Actual): December 1, 2013

Study Registration Dates

• First Submitted: June 21, 2011
• First Submitted That Met QC Criteria: June 23, 2011
• First Posted (Estimate): June 27, 2011

Study Record Updates

• Last Update Posted (Actual): March 5, 2019
• Last Update Submitted That Met QC Criteria: February 28, 2019
• Last Verified: February 1, 2019

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Glandular and Epithelial; Disease Attributes; Carcinoma; Recurrence; Physiological Effects of Drugs; Immunologic Factors; Antibodies, Monoclonal
• Other Study ID Numbers: 105OC201