Nutrient Synergy in Beef and Stimulation of Protein Synthesis in Elderly

January 17, 2012 updated by: University of Arkansas
This study will compare the effects of cooked, ground beef to those of beef protein isolate on blood and muscle proteins.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

STUDY OBJECTIVES Primary: To compare the effects of consumption of a 3-ounce serving of beef to that of a 20g serving of BPI on skeletal muscle synthetic and breakdown rate in healthy elderly subjects.

Secondary: To investigate the effect the study products on plasma levels of amino acids, insulin, and glucose in healthy elderly subjects.

Study Type

Interventional

Enrollment (Actual)

20

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Arkansas
      • Little Rock, Arkansas, United States, 72205
        • UAMS Center on Aging

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

60 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Healthy male or female.
  • Age 60 years or older.

Exclusion Criteria:

  • Any (history of) gastrointestinal disease that interferes with GI function
  • Diagnosed and active treatment of Diabetes Mellitus type I or II
  • History of congestive heart failure
  • Recent (6 months) hospitalization for heart disease treatment or management (e.g. PTCA, stent, surgery)
  • Myocardial infarction in the past year
  • Infection or fever in the 7 days prior to enrollment
  • Current use of corticosteroids, growth hormone, or testosterone
  • Adherence to a weight loss diet
  • Use of protein-containing or amino acid-containing nutritional supplements within one week of enrollment
  • Current alcohol (>7 ETOH per week) or drug abuse
  • Platelet count (PLT) < 100,000
  • History of hypo- or hyper-coagulation disorders including use of a coumadin derivative
  • Currently taking anti-thrombotics and cannot stop for 7 days (i.e. medical indication)
  • Allergy to local anesthetic
  • Blood hemoglobin < 9.0 g/dL
  • Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: 3 ounces of cooked, 85% lean ground beef
Subjects would consume 3 ounces of cooked, 85% lean ground beef at one setting on one day.
Dietary supplement: 3 ounces of cooked, 85% lean ground beef
Consumed once per subject.
Experimental: 20 grams of Beef protein isolate
Subjects would consume 20 grams of beef protein isolate dissolved into 200mL water at one setting on one day.
Dietary supplement: 20 grams beef protein isolate
Subjects would drink 200 ml water mixed with 20 grams of beef protein isolate one time.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
skeletal muscle synthetic and breakdown rate
Time Frame: day one
Using stable isotope infusion/ingestion methodology, we will measure plasma and skeletal muscle metabolic rate. Our primary end points will be muscle protein fractional synthesis rate (FSR) and whole body protein turnover rate.
day one

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
concentrations of plasma amino acids, insulin and glucose
Time Frame: day one
Secondary endpoints are concentrations of plasma amino acids, insulin and glucose.
day one

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Arkansas

Investigators

  • Principal Investigator: Robert R Wolfe, PhD, UAMS

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

July 1, 2011

Primary Completion (Actual)

September 1, 2011

Study Completion (Actual)

January 1, 2012

Study Registration Dates

First Submitted

August 10, 2011

First Submitted That Met QC Criteria

August 11, 2011

First Posted (Estimate)

August 12, 2011

Study Record Updates

Last Update Posted (Estimate)

January 18, 2012

Last Update Submitted That Met QC Criteria

January 17, 2012

Last Verified

January 1, 2012

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • UAMS IRB #132559

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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