Effect of Coffee Consumption on the Glycemic Index of Khalas Dates Tested in Healthy and Diabetic Subjects

August 23, 2011 updated by: Juma Alkaabi, United Arab Emirates University
The aim of this study was to evaluate the composition of Khalas, a very common type of dates used in the UAE and to determine the effects of drinking Arabic coffee on the results of GI tests in both healthy and diabetic subjects.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Background:The consumption of dates along with coffee is a deeply rooted habit in many societies. This study was designed to determine the effect of coffee consumption on the glycemic index of a common variety of dates (Khalas) tested in healthy subjects and individuals with type 2 diabetes mellitus.

Methods:Composition analysis was carried out for Khalas dates (Tamer stage) and the weight of the dates flesh equivalent to 50 g of available carbohydrate was calculated. The study subjects were thirteen healthy volunteers with a mean (± SD) age of 40.2 ± 6.7 years and ten participants with type 2 diabetes mellitus (controlled on lifestyle measures and/or metformin) with a mean HbA1c (± SD) of 6.6 ± (0.7 %) and a mean age (± SD) of 40.8 ± 5.7 years. Each subject was tested on five separate days with 50 g of glucose (on 3 occasions) and 50 g equivalent of available carbohydrates from the dates without coffee (on one occasion) and with coffee (on another occasion). Capillary glucose was measured in the healthy subjects at 0, 15, 30, 45, 60, 90 and 120 min and for the diabetics at 0, 30, 60, 90, 120, 150 and 180 min. The glycemic indices were determined as ratios of the incremental areas under the response curves for the dates alone/with coffee compared to glucose. Statistical analyses were performed using Student's t-tests.

Study Type

Interventional

Enrollment (Actual)

23

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United Arab Emirates
    • AB
      • Al Ain, AB, United Arab Emirates
        • Faculty of Medicine and Health Sciences UAE University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 60 years (ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • required that those in the healthy group were healthy and in the diabetes group that their diabetes was controlled (HbA1c ≤8%) on diet with or without metformin

Exclusion Criteria:

  • morbid obesity (BMI > 40 kg/m2)
  • pre diabetes
  • pregnancy
  • presence of gastroenterological disorders
  • alimentary tract surgery
  • a history of gastroenteritis in the prior six months
  • any alcohol intake
  • smoking
  • taking any medications (except metformin)
  • poorly controlled diabetes (HbA1c > 8%) and the presence of acute or chronic diseases

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Allocation: NON_RANDOMIZED
  • Interventional Model: SINGLE_GROUP
  • Masking: SINGLE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
ACTIVE_COMPARATOR: GI of Khalas dates
The Glycemic indices of the Khalas dates were measured for healthy and diabetic subjects.
Other: Khalas dates
every subject recieved 50 grams reducing carbohydrates equivalent of khalas dates
EXPERIMENTAL: GI of the Khalas dates with Coffee
measuring the effect of 100 ml of coffee consumption on the GI of the Khalas dates among healthy and diabetic subjects.
Other: Khalas dates
every subject recieved 50 grams reducing carbohydrates equivalent of khalas dates

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Glycemic Index of Khalas dates with and without coffee
Time Frame: 2 or 3 hours
Every subject recieved 50 grams reducing sugars of Khalas dates with and without coffee. Measuring glucose level over 2 hours in Healthy subjects and over 3 hours in diabetic subjects as per a standard protocol.
2 or 3 hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

United Arab Emirates University

Investigators

  • Principal Investigator: Juma M Alkaabi, MD, Assistant professor Internal Medicine Department FMHS UAE University
  • Study Chair: Bayan Al-Dabbag, PhD, FMHS UAE University
  • Study Chair: Hussein Saadi, MD, Professor of Medicine, FMHS UAE University
  • Study Chair: Salah Gariballa, MD, Professor of Medicine FMHS UAE University
  • Study Chair: Yasin Javed, Msc, FMHS UAE University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

March 1, 2010

Primary Completion (ACTUAL)

June 1, 2010

Study Completion (ACTUAL)

June 1, 2010

Study Registration Dates

First Submitted

August 18, 2011

First Submitted That Met QC Criteria

August 23, 2011

First Posted (ESTIMATE)

August 24, 2011

Study Record Updates

Last Update Posted (ESTIMATE)

August 24, 2011

Last Update Submitted That Met QC Criteria

August 23, 2011

Last Verified

August 1, 2011

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • UAEU: GI Dates Study

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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