- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01476033
Strong Women Study
April 9, 2013 updated by: Lamprecht Manfred PhD, PhD, Green Beat
Impact of Encapsulated Fruit, Berry and Vegetable Juice Powder Concentrate on Oxidative Stress, Inflammation and Blood Flow Before and Post Exercise in Overweight, Middle-aged, Women.
The investigators investigate the impact of an encapsulated fruit, berry and vegetable juice powder concentrate on oxidative stress, inflammation and blood flow before and post exercise in overweight, middle-aged, women.
Main hypotheses (H1):
- The nutraceutical has an impact on oxidative stress reduction.
- The nutraceutical has an impact on inflammation.
- The nutraceutical has an impact on blood flow and microcirculation.
- Walking exercise for 30 minutes has an impact on oxidative stress- and inflammation markers.
- Walking exercise for 30 minutes has an impact on blood flow and microcirculation
- The combination of nutraceutical supplementation + walking exercise for 30 minutes has an impact on oxidative stress- and inflammation markers, and on blood flow/microcirculation.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
44
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Graz, Austria, 8010
- Medical University of Graz
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
35 years to 50 years (ADULT)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
Female
Description
Inclusion Criteria:
- women
- BMI > 27
- praemenopausal
- non smokers
- eligibility for exercise
- 4wk wash out
Exclusion Criteria:
- male
- all people not matching this age group
- BMI > 40 and < 27
- peri- or postmenopausal women
- smokers
- all women taking dietary supplements
- all women that fail in ergometric exercise eligibility testing, refering to the standards in sports medicine (e.g.: significant ST-decrease or increase, blood pressure > 240 mmHg, tachycardia, polymorphic extrasystolia, cyanosis, bradyarrhythmia..)
- Diabetics
- osteoporosis or osteopenia
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: BASIC_SCIENCE
- Allocation: RANDOMIZED
- Interventional Model: PARALLEL
- Masking: DOUBLE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
ACTIVE_COMPARATOR: fruit, berry and vegetable concentrate
20 ladies receive an encapsulated, powdered fruit, berry and vegetable concentrate for 8 weeks
|
6 capsules of supplement or placebo for 8wk
|
PLACEBO_COMPARATOR: 20 women with placebo
placebo for 8 weeks
|
6 capsules of supplement or placebo for 8wk
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Carbonyl groups on protein, oxidized LDL, Malondialdehyde, TNF-alpha, IL-6, Trombelastometry and peripheral microcirculation
Time Frame: 6 months
|
Carbonyl groups on protein as indicators of protein oxidation; oxidized LDL, Malondialdehyde as indicators of Lipidoxidation; TNF-alpha, IL-6 as indicators of inflammation; Trombelastometry: clotting time, thrombocyte ahesion, trombocyte aggregation from whole blood as indicators for blood flow and hemostasis; Peripheral microcirculation in subcutis as indicator for blood flow in peripheral subcutis.
|
6 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
October 1, 2011
Primary Completion (ACTUAL)
April 1, 2012
Study Completion (ACTUAL)
December 1, 2012
Study Registration Dates
First Submitted
November 16, 2011
First Submitted That Met QC Criteria
November 17, 2011
First Posted (ESTIMATE)
November 22, 2011
Study Record Updates
Last Update Posted (ESTIMATE)
April 10, 2013
Last Update Submitted That Met QC Criteria
April 9, 2013
Last Verified
April 1, 2013
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 23-508 ex 10/11
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Inflammation
-
University of EdinburghUmeå UniversityCompletedSystemic Inflammation | Respiratory InflammationSweden
-
University of AarhusAarhus University Hospital; University of CopenhagenCompletedSystemic Inflammation | Airway InflammationDenmark
-
Sykehuset TelemarkRikshospitalet University Hospital; Helse Sor-OstCompletedAirway Inflammation | Peripheral Blood Inflammation Markers | Cement Dust ExposureNorway
-
Assistance Publique - Hôpitaux de ParisCompletedDigestive InflammationFrance
-
Pamukkale UniversityCompletedPeriodontal InflammationTurkey
-
Universidade Federal do ParaCompleted
-
KLE Society's Institute of Dental SciencesCompletedRegenerative InflammationIndia
-
Fondation Ophtalmologique Adolphe de RothschildCompleted
-
Oral Science International Inc.AdvarraNot yet recruiting
Clinical Trials on nutraceutical group
-
H2O Health and Agriculture LLCUnknownPneumonia | DiarrheaGuatemala
-
Universidad Católica San Antonio de MurciaCompletedOsteoarthritisSpain
-
University of PaviaCompletedHypertension | Diabetes Mellitus, Type 2 | DyslipidemiasItaly
-
Universidad Católica San Antonio de MurciaCompleted
-
Institut Pasteur de LilleCompleted
-
Neuromed IRCCSCompleted
-
DeNova ResearchTerminatedHair Loss | Hair ThinningUnited States
-
Universidad Católica San Antonio de MurciaCompleted
-
University of Missouri-ColumbiaNutramax Laboratories, Inc.Completed
-
River Pharma S.r.l.Opera CRO, a TIGERMED Group CompanyCompleted