Caffeine and Sodium Citrate Ingestion

Effects of Caffeine and Sodium Citrate Ingestion in 1500m Wheelchair Racing Athletes

A positive ergogenic effect of sodium citrate and caffeine ingestion in a short-term, high-intensity exercise task was shown by several studies. These studies were conducted with healthy, able-bodied subjects.

The aim of the study is to investigate whether caffeine or sodium citrate ingestion could enhance performance in spinal cord injured wheelchair athletes. It is a double blind, placebo controlled and randomized study.

Study Overview

• Status: Completed
• Conditions: Wheelchairs; Dietary Supplements; Heart Rate/Drug Effects; Lactic Acid/Metabolism; Physical Education and Training/Methods
• Intervention / Treatment: Dietary supplement: Caffeine; Dietary supplement: Sodium Chloride; Dietary supplement: Mannitol; Dietary supplement: Sodium Citrate

Detailed Description

The athletes have to complete four 1500m tests on a training roller. Before each treatment they get different supplementations. Once they get sodium citrate and a placebo, once caffeine and a placebo, once sodium citrate and caffeine and for the fourth treatment they get twice a placebo. Two hours after starting with the supplementation they have to complete the 1500m as fast as possible. Time to complete 1500m, blood pH, plasma bicarbonate, sodium concentration, heart rate, oxygen consumption, blood lactate concentration and rate of perceived exertion (RPE) were measured.

• Study Type: Interventional
• Enrollment (Actual): 9
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Switzerland
  • Lucerne
    • Nottwil, Lucerne, Switzerland, 6207
      • Swiss Paraplegic Centre

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 55 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• wheelchair athletes
• national team
• category T53 and T54

Exclusion Criteria:

• medicated
• pregnant (for women)
• cardiovascular and respiratory diseases

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Factorial Assignment
• Masking: Triple

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Caffeine; 6mg per kg bodyweight ingested 60min before test	Dietary supplement: Caffeine; gelatine capsule 6mg/kg bodyweight 60min prior test; Dietary supplement: Sodium Chloride; sodium chloride diluted in 7dl water 0.045g/kg bodyweight 120-90min prior test
Placebo Comparator: Placebo; Sodium chloride and mannitol as placebo are ingested by the athlete	Dietary supplement: Sodium Chloride; sodium chloride diluted in 7dl water 0.045g/kg bodyweight 120-90min prior test; Dietary supplement: Mannitol; gelatine capsule filled with mannitol (100mg per capsule) ingested 60min prior test
Active Comparator: Sodium Citrate; sodium citrate diluted in 7dl water, ingestion 120 to 90min prior test	Dietary supplement: Mannitol; gelatine capsule filled with mannitol (100mg per capsule) ingested 60min prior test; Dietary supplement: Sodium Citrate; 0.5g/kg bodyweight diluted in 7dl water ingested 120-90min prior test
Active Comparator: Caffeine and Sodium Citrate; sodium citrate 120-90min prior test capsules:60min prior test	Dietary supplement: Caffeine; gelatine capsule 6mg/kg bodyweight 60min prior test; Dietary supplement: Sodium Citrate; 0.5g/kg bodyweight diluted in 7dl water ingested 120-90min prior test

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time	Time to complete 1500m	3 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Heart Rate	Heart Rate measured from 2min before the test until 5min after the 1500m-test.	during study phase of 3 week (4 tests)
Lactate Concentration	1min before starting the warm up, 15s after the end of the warm up, 15s after completing the test, 2min/4min/6min/8min/10min after the test	during the 3 weeks study phase
blood pH, sodium concentration and plasma bicarbonate	1min before starting with the ingestion of the fluid, immediately before starting the warm up, just immediately before starting the 1500m test.	during the 3 weeks of study phase
Oxygen Consumption	oxygen consumption (VO2(ml/min/kg), VCO2(ml/min), RER (VCO2/VO2)) starting of the measurement is 2min before the start of the 1500m and ends 2min after having completed the 1500m	during 3 weeks of study phase
rating of gastrointestinal stress	1min before starting to drink the fluid, 2min before starting with the warm up, 2min before the test and 2min after having completed the 1500m	during the 3 weeks of study phase
Rating of Perceived Exertion (RPE)	15s after the end of the warm up, 15s after having completed the 1500m	during the 3 weeks of study phase

Collaborators and Investigators

• Sponsor: Swiss Paraplegic Centre Nottwil
• Investigators: Principal Investigator: Claudio Perret, Dr. sc. nat., Swiss Paraplegic Centre Nottwil

Study record dates

Study Major Dates

• Study Start: February 1, 2012
• Primary Completion (Actual): September 1, 2012
• Study Completion (Actual): September 1, 2012

Study Registration Dates

• First Submitted: April 3, 2012
• First Submitted That Met QC Criteria: May 1, 2012
• First Posted (Estimate): May 3, 2012

Study Record Updates

• Last Update Posted (Estimate): November 22, 2016
• Last Update Submitted That Met QC Criteria: November 21, 2016
• Last Verified: November 1, 2016

More Information

Terms related to this study

• Keywords: caffeine; exercise performance; sodium citrate; wheelchair athletes; 1500m
• Additional Relevant MeSH Terms: Physiological Effects of Drugs; Neurotransmitter Agents; Molecular Mechanisms of Pharmacological Action; Enzyme Inhibitors; Purinergic Antagonists; Purinergic Agents; Natriuretic Agents; Diuretics, Osmotic; Diuretics; Anticoagulants; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Chelating Agents; Sequestering Agents; Central Nervous System Stimulants; Calcium Chelating Agents; Mannitol; Caffeine; Citric Acid; Sodium Citrate
• Other Study ID Numbers: 2012-02 (AP HM)