Multidisciplinary Team IntervenTion in CArdio-ONcology (TITAN Study) (TITAN)

May 6, 2026 updated by: University of Alberta

Multidisciplinary Team IntervenTion in CArdio-ONcology

People with breast cancer often experience many short and long-term side effects as a result of both the cancer and the necessary treatments.

Receiving extra assessments and care from teams of multiple health professionals has been shown to be helpful for people with other health problems, such as heart disease. These 'multidisciplinary' teams may include nurses, doctors, pharmacists, dietitians, exercise therapists, counselors, and other specialists. Currently, the investigators do not know if receiving extra assessments from a multidisciplinary team is helpful for people receiving cancer treatment.

In this study, the investigators hope to learn the effect of extra assessments and early interventions from teams of health care professionals in people diagnosed with cancer, during and after the treatment period.

After initial assessments, participants will be randomized to multidisciplinary team intervention or usual care.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

80

Phase

  • Phase 2

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Canada
    • Alberta
      • Edmonton, Alberta, Canada, T6G 1Z2
        • Cross Cancer Institute

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • histologically confirmed malignancy (breast or lymphoma);
  • scheduled to receive anthracycline and/or trastuzumab-based chemotherapy;
  • age ≥ 18 years;
  • willing to attend follow-up visits.

Exclusion Criteria:

  • physical disability preventing exercise testing or DEXA scan;
  • psychiatric disease or disorder precluding informed consent;
  • participation in other cardiotoxicity or exercise intervention study;
  • contraindication to anti-cancer therapy, including known heart failure, cardiomyopathy, or baseline LVEF < 50%;
  • previous anthracycline or trastuzumab-based therapy;
  • previous radiotherapy to thorax.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Supportive Care
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: multidisciplinary team intervention
Intervention arm receives regular assessments and treatments from cardiology team, clinical nutrition, pharmacist, exercise physiologist and physiotherapist
Behavioral: Multidisciplinary team intervention
Intervention arm receives regular assessments and treatments from cardiology team, clinical nutrition, pharmacist, exercise physiologist and physiotherapist
Other Names:
  • cardiology assessment and intervention
  • nutritional assessment and intervention
  • exercise assessment and training
  • pharmacist assessment and counseling
  • physiotherapy assessment and training
No Intervention: Observational arm
Participants randomized to observational arm will receive usual care.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
cardiac MRI
Time Frame: change from baseline to 12 months
left ventricular ejection fraction (LVEF)
change from baseline to 12 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
serum biomarkers
Time Frame: change from baseline to 12 months
percent change in established biomarkers (troponin, BNP)
change from baseline to 12 months

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
multidisciplinary team interventions
Time Frame: change from baseline to 12 months
nutrition, exercise, physiotherapy interventions
change from baseline to 12 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Alberta

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

May 1, 2014

Primary Completion (Actual)

May 30, 2018

Study Completion (Estimated)

December 3, 2026

Study Registration Dates

First Submitted

June 4, 2012

First Submitted That Met QC Criteria

June 13, 2012

First Posted (Estimated)

June 18, 2012

Study Record Updates

Last Update Posted (Actual)

May 11, 2026

Last Update Submitted That Met QC Criteria

May 6, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • TITAN 102

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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