Adaptive Treatment for Adolescent Cannabis Use Disorders

The purpose of this study is to examine an Adaptive Treatment approach in order to improve outcomes of youth with Cannabis Use Disorders who are poor responders to treatment.

Study Overview

• Status: Completed
• Conditions: Mental Disorders; Cannabis Use Disorder; Addictive Behaviors
• Intervention / Treatment: Behavioral: ACRA; Behavioral: CBT

Detailed Description

The study will address the current contrasts in youth response to treatment, the problem of poor response to treatment and the prevention of relapse. Results from the study may support Adaptive Treatment as an efficacious approach for youth with Cannabis Use Disorder who are poor responders to treatment.

Poor responders fall into two categories, those who failed to achieve a negative drug urinalysis during the last session of the initial MET/CBT-7 treatment they attended, and those who either dropped out or were administratively discharged at any time during the initial MET/CBT-7 treatment.

• Study Type: Interventional
• Enrollment (Actual): 172
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Connecticut
    • Farmington, Connecticut, United States, 06030-2103
      • University of Connecticut Health Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 13 years to 18 years (ADULT, CHILD)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• 13-18 years of age at the time of intake assessment
• Current diagnosis of DSM-IV Cannabis Abuse or Dependence
• Able to read and comprehend English at a 5th grade level
• Residence within 45 minutes drive from the UCHC Farmington treatment site
• Participant and a parent/legal guardian responsible for providing collateral information agree to sign an IRB approved consent form
• Participant and a parent/legal guardian responsible for providing collateral information agree to provide locator information
• The family is not planning to move from the area during the next six months

Exclusion Criteria:

• Meet criteria for dependence of any other substance of abuse other than nicotine or alcohol
• Report suicidal ideation with a plan, suicidal behavior, a plan to hurt oneself or other, or a history of self-injurious behavior all occurring in the last 30 days
• Meet a lifetime diagnosis of schizophrenia
• Has any current health (i.e. medical, psychiatric) condition that will compromise the participant's ability to regularly attend treatment
• Demonstrate an inability or unwillingness to provide locator information

Study Plan

How is the study designed?

Design Details

• Primary Purpose: TREATMENT
• Allocation: RANDOMIZED
• Interventional Model: PARALLEL
• Masking: NONE

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: ACRA; Ten weekly 60-minute sessions of Adolescent Community Reinforcement Approach (ACRA) will be provided as an Adaptive treatment condition.	Behavioral: ACRA; Ten weekly,60-minute therapy sessions including six individual, two parent/guardian and two joint (individual and parent/guardian).; Other Names: Adolescent Community Reinforcement Approach
EXPERIMENTAL: Cognitive Behavioral Therapy (CBT); Ten weekly, 60-minute sessions of augmented individualized Cognitive Behavioral Therapy (CBT)will be provided as an Adaptive Treatment condition	Behavioral: CBT; 10 weekly, 60-minute sessions of augmented individualized CBT; Other Names: Cogntive Behavioral Therapy

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
1.) To evaluate the efficacy of AT for youth who have been defined as poor responders to an evidence-based practice intervention such as the initial MET/CBT-7.	Each participant will serve as his/her own control. The outcomes will include the T-ASI, T-ASI-P, and drug urinalyses.	one year

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
To assess outcomes as a function of mediator variables such as self-efficacy, coping skills, readiness to change, and environmental support (i.e., family and peer), within each of the AT interventions.	The secondary outcome measures will include the SCQ, CRI, PRQ, and SSQ.	one year

Collaborators and Investigators

• Sponsor: UConn Health
• Collaborators: National Institute on Drug Abuse (NIDA)
• Investigators: Principal Investigator: Yifrah Kaminer, MD, MBA, UConn Health

Study record dates

Study Major Dates

• Study Start: September 1, 2011
• Primary Completion (ACTUAL): July 1, 2016
• Study Completion (ACTUAL): July 1, 2016

Study Registration Dates

• First Submitted: August 1, 2012
• First Submitted That Met QC Criteria: August 1, 2012
• First Posted (ESTIMATE): August 3, 2012

Study Record Updates

• Last Update Posted (ACTUAL): April 11, 2017
• Last Update Submitted That Met QC Criteria: April 10, 2017
• Last Verified: April 1, 2017

More Information

Terms related to this study

• Keywords: Adolescents; Substance Use Disorders
• Additional Relevant MeSH Terms: Chemically-Induced Disorders; Pathologic Processes; Substance-Related Disorders; Compulsive Behavior; Impulsive Behavior; Disease; Mental Disorders; Marijuana Abuse; Behavior, Addictive
• Other Study ID Numbers: PA08-263; R01DA030454 (NIH)