Childhood Body Composition and Brain Structure and Function

The specific aim of this research project is to use MRI methods to evaluate and compare brain structure and function in normal weight and obese children age 8-10 years.

Study Overview

• Status: Completed
• Conditions: Healthy

• Study Type: Observational
• Enrollment (Actual): 27

Contacts and Locations

Study Locations

• United States
  • Arkansas
    • Little Rock, Arkansas, United States, 72203
      • Arkansas Children's Nutrition Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 8 years to 10 years (Child)
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Healthy normal weight or obese children (age 8-10 years)

Description

Inclusion Criteria:

• Healthy normal weight or obese children
• Parental report of full-term gestation
• Parental report of birth weight between 5th-95th percentiles
• Parental report of breastfeeding or cow's milk formula fed during infancy
• Right hand dominance

Exclusion Criteria:

• Maternal diabetes
• Maternal alcohol, tobacco or drug use during pregnancy
• Chronic sleep disorder
• History of psychological or psychiatric diagnosis
• History of neurological impairment or injury
• Surgical implant or other foreign object in the body which may be a MRI safety concern
• Dental work which may cause artifacts in MRI
• Claustrophobia
• High likelihood of inability to tolerate loud noise from the MRI scanner

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Obese
Normal weight

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Brain structure	We will use high resolution volumetric MRI and DTIto measure the brain structure of these children	8 - 10 years of age

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Brain Function	We will use high resolution fMRI to measure the brain function under different cognitive paradigms	8-10 years of age

Collaborators and Investigators

• Sponsor: Arkansas Children's Hospital Research Institute
• Investigators: Principal Investigator: Xiawei Ou, PhD, Arkansas Children's Nutrition Center

Study record dates

Study Major Dates

• Study Start: January 1, 2012
• Primary Completion (Actual): August 1, 2013
• Study Completion (Actual): August 1, 2014

Study Registration Dates

• First Submitted: February 26, 2013
• First Submitted That Met QC Criteria: April 1, 2013
• First Posted (Estimated): April 2, 2013

Study Record Updates

• Last Update Posted (Estimated): December 20, 2023
• Last Update Submitted That Met QC Criteria: December 18, 2023
• Last Verified: December 1, 2023

More Information

Terms related to this study

• Other Study ID Numbers: 133540