The Effect of Ischemic Pre-Conditioning on the Rate of Recovery Following Exercise-Induced Muscle Damage

The Effect of Ischemic Pre-Conditioning on the Rate of Recovery Following Exercise-Induced Muscle Damage: a Randomized Control Trial

Strenuous exercise or exercise involving eccentric muscle contractions can lead to muscle damage and changes in muscle function; this is known as exercise-induced muscle damage (EIMD). It is known that brief, repeated periods of ischemia followed by reperfusion, known as Ischemic Preconditioning (IPC) cause a delay in cell injury in cardiac muscle as well as in various other organs.

Therefore the purpose of this study is to:

1. Quantify the use of IPC in recovery following EIMD.
2. Identify any effect of IPC during recovery on muscle function

Study Overview

• Status: Completed
• Conditions: Exercise-induced Muscle Damage
• Intervention / Treatment: Other: Ischemic Preconditioning

• Study Type: Interventional
• Enrollment (Anticipated): 24
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United Kingdom
  • London, United Kingdom, TW1 4SX
    • St Marys Umiversity College

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 45 years (ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• Physically Active Males

Exclusion Criteria:

• Muscular skeletal disorders

Study Plan

How is the study designed?

Design Details

• Primary Purpose: TREATMENT
• Allocation: RANDOMIZED
• Interventional Model: PARALLEL
• Masking: SINGLE

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Ischemic Preconditioning; IPC (4 x 5 minute cycles @ 220 mmHg) with 5 min reperfusion between trials.	Other: Ischemic Preconditioning
Placebo Comparator: Ischemic Preconditioning Placebo; Placebo (4 x 5 minute cycles @ 20mmHg) with 5 minutes between each cycle	Other: Ischemic Preconditioning

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change from baseline in maximal voluntary contraction	Isometric MVC of the participants' dominant knee extensors was assessed using a strain gauge. MVCs were performed for 3 s with a 60 s rest between each repetition. The change in MVC will be determined 24, 48 and 72 hours following pre exercise conditions.	pre exercise, 24 hours post, 48 hours post and 72 hours post exercise

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change from baseline in Creatine kinase	Plasma CK was determined from an earlobe capillary blood sample. The sample (10 microlitres) was analysed immediately using an semi-automated clinical chemistry analyser. The change in CK will be determined 24, 48 and 72 hours following pre exercise conditions	pre exercise, 24 hours post, 48 hours post and 72 hours post exercise
Change from baseline in Limb girth	Mid-thigh and calf circumference was assessed as a measure of limb swelling using an anthropometric tape measure. Both measures were obtained with the participant in a standing position. The change in limb girth will be determined 24, 48 and 72 hours following pre exercise conditions	pre exercise, 24 hours post, 48 hours post and 72 hours post exercise
Chnage from baseline in Vertical jump	Vertical jump (VJ) performance was assessed using an electronic timing mat with hands placed on hips and participants dropping down to a self-selected level before jumping maximally. The change in VJ will be determined 24, 48 and 72 hours following pre exercise conditions	pre exercise, 24 hours post, 48 hours post and 72 hours post exercise
Change from baseline in Muscle soreness	Muscle soreness - Participants were asked to perform and hold a squat (90° knee angle) whilst they rated their perceived muscle soreness on a 200 mm visual analogue scale. The scale consisted of a line from 0 mm (no pain) to 200 mm (unbearably painful). The change in muscle soreness will be determined 24, 48 and 72 hours following pre exercise conditions	pre exercise, 24 hours post, 48 hours post and 72 hours post exercise

Collaborators and Investigators

• Sponsor: St Mary's University College

Study record dates

Study Major Dates

• Study Start: July 1, 2013
• Primary Completion (Actual): November 1, 2013
• Study Completion (Actual): November 1, 2013

Study Registration Dates

• First Submitted: July 15, 2013
• First Submitted That Met QC Criteria: July 22, 2013
• First Posted (Estimate): July 25, 2013

Study Record Updates

• Last Update Posted (Estimate): March 6, 2014
• Last Update Submitted That Met QC Criteria: March 5, 2014
• Last Verified: March 1, 2014

More Information

Terms related to this study

• Keywords: Investigate IPC on EIMD
• Other Study ID Numbers: IPCEIMD001