Effect of Hula Hooping as Compared to Walking on Adipose Tissue Distribution, Metabolic Parameters and Adipose Tissue Gene Expression

o determine effects of hula-hooping on android obesity, metabolic parameters and adipose tissue (AT) gene expression.

Study Overview

• Status: Completed
• Conditions: Android Obesity, Metabolic Parameters and Adipose Tissue (AT) Gene Expression
• Intervention / Treatment: Other: Exercise

• Study Type: Interventional
• Enrollment (Actual): 53
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Finland
  • Helsinki, Finland, FI-00290
    • Department of Medicine, University of Helsinki

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 70 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• age between 18 and 70 years
• central adiposity as measured by the waist circumference (>80 cm in females and >94 cm in males) (9)
• ability to hula-hoop for a minimum of 2 minutes and to have the necessary space available for this activity either at home or at work
• ability to communicate meaningfully with the investigator and legal competence to provide written informed consent

Exclusion Criteria:

• clinical or biochemical evidence of disease other than obesity as judged by history, physical examination and standard laboratory tests
• excessive use of alcohol, i.e., over 20 g/day
• use of medications known to affect glucose or lipid metabolism and
• pregnancy or lactation

Study Plan

How is the study designed?

Design Details

• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Walking; WALK. The participants were instructed to walk daily, at first week 12minutes/day, week II 16mins/day, week III 20mins/day, week IV 24 mins/day, week V 28mins/day, week VI 32mins/day at a pace that would moderately increase heart rate and result in sweating	Other: Exercise
Active Comparator: Hula-hooping; HULA. The participants were instructed to hula hoop daily, at first week 6minutes/day, week II 8mins/day, week III 10mins/day, week IV 12 mins/day, week V 14mins/day, week VI 16mins/day	Other: Exercise

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Android obesity	The primary objective was to evaluate the change in the % fat in the android region as measured by DEXA during 6 weeks of HULA as compared to WALK	6weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
metabolic parameters	The secondary objectives included the comparison of differences in waist circumference (cm), relative and absolute trunk and limb muscle mass as measured by DEXA (% and kg), fasting plasma glucose (mmol/l), fasting serum insulin (mU/l), liver enzymes (U/l), fasting plasma LDL and HDL cholesterol and triglycerides (mmol/l). Gene expression was analyzed in adipose tissue biopsies collected before and after each exercise intervention.	6weeks

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
adipose tissue inflammation	To determine the effects of HULA compared to WALK on adipose tissue inflammation, a needle aspiration biopsy of abdominal s.c. adipose tissue was taken under local anesthesia with lidocaine before and after each exercise intervention. The adipose tissue sample was immediately frozen in liquid nitrogen and then stored at -80°C until analysis. Total RNA from s.c. AT was isolated.Relative quantification for the genes of interest (see list below) was carried out using normalization to the 36B4 and β-actin mRNA values. ABCA1 Adiponectin ANGPTL8 CHOP CD4 CD8 CD68 ETFDH FOXP3 GLUT4 MCP-1 MRC-1 PGC-1α VEGF-A β-actin	6weeks

Collaborators and Investigators

• Sponsor: University of Helsinki

Publications and helpful links

General Publications

• Lahelma M, Sadevirta S, Lallukka-Bruck S, Sevastianova K, Mustelin L, Gylling H, Rockette-Wagner B, Kriska AM, Yki-Jarvinen H. Effects of Weighted Hula-Hooping Compared to Walking on Abdominal Fat, Trunk Muscularity, and Metabolic Parameters in Overweight Subjects: A Randomized Controlled Study. Obes Facts. 2019;12(4):385-396. doi: 10.1159/000500572. Epub 2019 Jun 19. Erratum In: Obes Facts. 2019;12(5):589.

Study record dates

Study Major Dates

• Study Start: November 1, 2011
• Primary Completion (Actual): March 1, 2012
• Study Completion (Actual): March 1, 2012

Study Registration Dates

• First Submitted: June 18, 2013
• First Submitted That Met QC Criteria: July 30, 2013
• First Posted (Estimate): July 31, 2013

Study Record Updates

• Last Update Posted (Estimate): July 31, 2013
• Last Update Submitted That Met QC Criteria: July 30, 2013
• Last Verified: July 1, 2013

More Information

Terms related to this study

• Other Study ID Numbers: HULA 233401; HULA233401 (Other Identifier: HUS Tietu)

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No