Bioavailability of Anthocyanins of Blue Potatoes as Compared With Bilberries

In this study, the postprandial glycemia and insulinemia caused by boiled potato with blue-fleshed or yellow-fleshed tubers, or a gel prepared with bilberries and potato starch, is studied in healthy males. Additionally, the appearance and metabolism of the flavonoids and their metabolites is studied in plasma and urine.

Study Overview

• Status: Completed
• Conditions: Postprandial Glycemia
• Intervention / Treatment: Other: Dietary intervention

• Study Type: Interventional
• Enrollment (Actual): 14
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Finland
  • Turku
    • University of Turku, Turku, Finland, 20014
      • Department of Biochemistry, University of Turku

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 45 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• Age 18-45
• Male
• No regular medication
• No participation in a drug trial or blood donation within 2 months
• Non-smoker
• Signs informed consent
• Body mass index 18.5-27 kg/m2
• Fasting plasma cholesterol < 5.5 mmol/l
• Fasting plasma triacylglycerols < 2.6 mmol/l
• Fasting plasma glucose 4-6 mmol/l
• blood pressure <140/80 mmHg
• hemoglobin>130 g/l
• Fasting plasma alanine amino transferase (ALAT) <60 U/l (normal liver function)
• Fasting plasma thyroid-stimulating hormone (TSH) 0.4 - 4.5 mU/l (normal thyroid function)
• Fasting plasma creatinine <118 µmol/l (normal kidney function)

Exclusion Criteria:

• Regular smoking
• Alcohol abuse
• Regular medication

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Single

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Blue-fleshed potato tubers; Intervention: Steam cooked mashed potato tubers	Other: Dietary intervention
Experimental: Yellow-fleshed potato tubers; Intervention: Steam cooked mashed potato tubers	Other: Dietary intervention
Experimental: Bilberries and potato starch; Intervention: A gel boiled with bilberries and potato starch	Other: Dietary intervention

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Plasma glucose concentration	20min, 40min, 60min, 90min, 120min, 180min, 240min
Plasma insulin concentration	20min, 40min, 60min, 90min, 120min, 180min, 240min

Secondary Outcome Measures

Outcome Measure	Time Frame
Concentrations and quality of flavonoid color compounds or their metabolites in plasma and urine (HPLC-measurement)	20min, 40min, 60min, 90min, 120min, 180min, 240min
Concentrations and quality of flavonoid color compounds or their metabolites in plasma and urine (NMR-measurement)	20min, 40min, 60min, 90min, 120min, 180min, 240min

Collaborators and Investigators

• Sponsor: University of Turku

Study record dates

Study Major Dates

• Study Start: December 1, 2013
• Primary Completion (Actual): May 1, 2015
• Study Completion (Actual): May 1, 2015

Study Registration Dates

• First Submitted: December 3, 2013
• First Submitted That Met QC Criteria: December 3, 2013
• First Posted (Estimate): December 9, 2013

Study Record Updates

• Last Update Posted (Estimate): May 20, 2015
• Last Update Submitted That Met QC Criteria: May 19, 2015
• Last Verified: May 1, 2015

More Information

Terms related to this study

• Other Study ID Numbers: Siniset perunat